Abstract：
:Atrazine is a commonly used herbicide that has previously been implicated as an endocrine-disrupting compound. Previous studies have shown that estrogenic endocrine-disrupting compounds affect the development of the heart, cartilage, and bone in zebrafish ( Danio rerio). To determine whether atrazine has effects similar to other endocrine disruptors, zebrafish embryos were treated with a range of atrazine concentrations. Atrazine treatment at a low concentration of 0.1 µM resulted in significant differences in craniofacial cartilage elements, while concentrations ≥1 µM led to decreased survival and increased heart rates. Fish treated with ≥1 µM atrazine also developed with delayed vertebrae mineralization. Higher concentrations of atrazine caused gross craniofacial defects and decreased hatching rates. Further studies into the molecular pathways disrupted in these developmental processes could shed light on a link between endocrine-disrupting compounds and developmental abnormalities.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Walker BS,Kramer AG,Lassiter CSdoi
10.1177/0748233718760419subject
Has Abstractpub_date
2018-05-01 00:00:00pages
329-338issue
5eissn
0748-2337issn
1477-0393journal_volume
34pub_type
杂志文章abstract：:The Agency for Toxic Substances and Disease Registry (ATSDR) prepared this health consultation to provide support for assessing the public health implications of hazardous chemical exposure, primarily through drinking water, related to releases of chromated copper arsenate (CCA) in the port of Djibouti. CCA from a shi...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233707076810
更新日期：2007-05-01 00:00:00
abstract：:A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378500100412
更新日期：1985-12-01 00:00:00
abstract：:The risk assessment process must encompass all available toxicological data and scientific evidence on the plausible toxicities of a chemical or chemical mixture. As an extension to the approaches used to conduct risk assessments on chemical mixtures, a preliminary scheme, analogous to the IARC classification of carci...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：:Brominated flame retardants (BFRs) and heavy metals (HMs) are two main types of pollutants in electronic waste recycling sites, which are also ubiquitously detectable in environmental media and human tissues. However, the adverse health effects of exposure to the mixture of these types of pollutants are unknown. In th...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233718779478
更新日期：2018-09-01 00:00:00
abstract：:In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only a...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233712462442
更新日期：2014-08-01 00:00:00
abstract：:This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage...
journal_title：Toxicology and industrial health
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doi：10.1177/0748233715572561
更新日期：2016-09-01 00:00:00
abstract：:The US EPA and the California Air Resources Board studied the exposures of 51 residents of Los Angeles, CA to 25 volatile organic chemicals in air and drinking water in February and July of 1987. Participants carried a personal air monitor consisting of a Tenax cartridge and a small sampling pump for two consecutive 1...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379100700523
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abstract：:Microbiological studies were carried out on microbial contamination and antimicrobial activity of sea cucumber Holothuria polii collected from Mediterranean Sea at Abu-kir shore of Alexandria, Egypt. The obtained results revealed the presence of isolates of five human Gram-negative pathogenic bacteria, representing fi...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233712448116
更新日期：2013-11-01 00:00:00
abstract：:Methiocarb (MC) is a widely used carbamate pesticide in agriculture and health programs. Although the main molecular mechanism of carbamate toxicity involves acetylcholinesterase inhibition, studies have also implicated the induction of oxidative stress. Therefore, the present study was aimed to evaluate the effect of...
journal_title：Toxicology and industrial health
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doi：10.1177/0748233712446719
更新日期：2013-02-01 00:00:00
abstract：:This study demonstrates the detection and dynamics of macrocyclic trichothecene mycotoxin (MTM) tissue loading using a commercially available assay in a goat model. The detection of MTMs has been difficult and complex due to the uncertainty of what tissues to examine and when to sample. Twelve goats (two groups of eac...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233709348275
更新日期：2009-10-01 00:00:00
abstract：:Kinetic interactions among chemicals present in a mixture can influence the relationship between administered and delivered or effective dose; these interactions are distinct from dynamic interactions such as, for example, competition between two chemicals for receptor binding sites. The relationship between administe...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823378900500507
更新日期：1989-10-01 00:00:00
abstract：:The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378900500308
更新日期：1989-05-01 00:00:00
abstract：:Chloropentafluorobenzene (CPFB) has been identified as a candidate simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/liter resulted in reduced weight...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823379100700406
更新日期：1991-07-01 00:00:00
abstract：:The aim of this study is to evaluate the role of curcumin on acute lung injury induced by intestinal ischaemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into 3 groups: sham, I/R, and I/R + curcumin; each group contains 10 animals. Sham group animals underwent laparotomy without I/R injury. ...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233711430984
更新日期：2013-08-01 00:00:00
abstract：:This paper describes the development and implementation of physiologically-based pharmacokinetic (PB-Pk) models to examine the disposition of xenobiotics and their bioactivation. In a PB-Pk model, the structure of the model is based, to as great extent as practicable, on the actual physiological and biochemical struct...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：10.1177/074823379401000101
更新日期：1994-01-01 00:00:00
abstract：:The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714566875
更新日期：2016-08-01 00:00:00
abstract：:The reporting of physical symptoms is influenced to a large degree by psychological processes. Individuals are more likely to notice subtle sensations in environments lacking in stimulation than those demanding external attention. The beliefs or schemas that people hold dictate where and how they attend to their bodie...
journal_title：Toxicology and industrial health
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/0748233714566877
更新日期：2016-08-01 00:00:00
abstract：:Hepatocytes that were isolated from 48 hr starved rats and incubated in Krebs-Henseleit bicarbonate buffer containing 10 microM A23187, 10mM l-lactate, 1mM pyruvate and 2mM l-lysine were found to contain 0.064 mumol of inorganic pyrophosphate/g wet wgt cells. Addition of either 20mM acetate or butyrate, which caused t...
journal_title：Toxicology and industrial health
pub_type： 杂志文章
doi：10.1177/074823378600200308
更新日期：1986-09-01 00:00:00
abstract：:Recently, we have detailed a DNA alkaline unwinding assay (DAUA) that can be used to rapidly measure chemically induced strand breaks in mammalian cells (Daniel et al., 1985). In this paper we present further development of this assay, including: (1) studies on the relationship between DNA adducts and DNA strand break...
journal_title：Toxicology and industrial health
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doi：10.1177/074823378900500506
更新日期：1989-10-01 00:00:00
abstract：:Occupational exposure in a copper smelting industry may produce various adverse health effects including cancer. Despite a number of well-documented studies reporting an increased risk of cancer among copper smelter workers, the data on genotoxic effects in this industry are scarce. In view of the above, an assessment...
journal_title：Toxicology and industrial health
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abstract：:Male infertility can be caused by environmental factors, genetic defects, physiological and endocrine deficiencies and testicular pathologies. Aluminium (Al) can cause male infertility through a number of mechanisms. The aim of our study was thus to determine whether vitamin E (VitE) has protective effects on Al-induc...
journal_title：Toxicology and industrial health
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更新日期：2020-04-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of resveratrol on kidney tissue of rats exposed to cigarette smoke. Forty adult male Wistar Albino rats were divided into four groups. Animals in group 1 was the control group. For 6 weeks, group 2 was exposed to cigarette smoke; group 3 received daily intraperitoneal i...
journal_title：Toxicology and industrial health
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doi：10.1177/0748233709346755
更新日期：2009-09-01 00:00:00
abstract：:This investigation used a two-source capture-recapture method (CRM) for determining ascertainment and undercounts of non-national priority listed hazardous waste sites in the states of Arizona, Maine and Pennsylvania. These findings suggest that ascertainment of hazardous waste sites vary greatly, with some more accur...
journal_title：Toxicology and industrial health
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更新日期：2003-07-01 00:00:00
abstract：:In the present study, the single and combined neurotoxic effects of benzo[a]pyrene ([BaP] 0.0, 0.5, and 5.0 mg/kg body weight; intragastric administration) and lead acetate (0.0, 5.4, and 54.0 mg/L; by drinking water) were examined on KunMing mice. In the Morris water maze, results showed that BaP and lead induced syn...
journal_title：Toxicology and industrial health
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更新日期：2013-06-01 00:00:00
abstract：:Groups of five male and five female rats were fed diets containing from 0% to 2.5% di(2-ethylhexyl)terephthalate (DEHT) or 1.2% di(2-ethylhexyl)phthalate (DEHP) for 21 days. Feed consumption and body weight gains were collected and, at study termination, animals were examined for alterations in body weight, difference...
journal_title：Toxicology and industrial health
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更新日期：1987-06-01 00:00:00
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journal_title：Toxicology and industrial health
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abstract：:Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days. A sub-lethal dose of C...
journal_title：Toxicology and industrial health
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更新日期：2010-03-01 00:00:00
abstract：:The aim of this study was to evaluate the global scientific output of neurotoxicity of nanoparticles (NPs) and explore their hot spots and research trends. Articles about the neurotoxicity of NPs between 2008 and 2017 were taken from the Web of Science Core Collection database. The VOSviewer was used to analyze annual...
journal_title：Toxicology and industrial health
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更新日期：2018-12-01 00:00:00
abstract：:The anti-genotoxic potential of hydrated sodium calcium aluminosilicate (HSCAS) was investigated using sister chromatid exchanges (SCEs) induced by aflatoxin B1 (AFB1) as genotoxic endpoint in human lymphocytes. Whole blood samples from two healthy male donors were used for this experiment and the effects of different...
journal_title：Toxicology and industrial health
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doi：10.1177/0748233707076738
更新日期：2007-03-01 00:00:00
