Abstract:
:The negative health effects caused by lead (Pb) exposure are widely recognized; however, the molecular mechanisms remain unknown. The aim of this study was to assess the effect of occupational Pb exposure on telomere length and to investigate the potential mechanisms leading to telomere shortening. A cohort of 334 male Pb smelters (exposed group) and 60 age-adjusted males unexposed to Pb (control group) were examined. Assessments of relative telomere length (rTL) and telomerase reverse transcriptase (TERT) gene expression were performed using quantitative real-time polymerase chain reactions. Assessments of whole blood Pb (B-Pb) and whole blood cadmium (B-Cd) concentrations and serum selenium concentration (S-Se) were performed using graphite furnace atomic absorption spectrometry. We analyzed total oxidation status (TOS), lipid hydroperoxides (LHPs), malonylodialdehyde levels in serum (MDA) and in erythrocyte hemolysates (MDA-hgb), and 8-hydroxy-deoxy-guanosine (8-OHdG). The Pb-exposed group had higher B-Pb values and shorter rTL than the control group. The arithmetic mean values calculated for B-Pb were 33 µg/dL versus 2.2 µg/dL (p < 0.0001), and the rTL values were 0.928 and 1.126 relative units (p = 0.001), respectively, for the Pb-exposed and control groups. The rTL was found to gradually shorten in response to the increasing levels of Pb exposure. The Pb-exposed group also demonstrated a higher level of oxidative stress than the control group, which was indicated by increased TOS and MDA-hgb values. rTL was negatively associated with parameters that indicated increased oxidative stress, including TOS (Spearman's rank coefficient (rS) = -0.16; p < 0.01) and MDA-hgb (rS = -0.17; p < 0.001). No correlations were found between rTL and B-Cd and S-Se or smoking and MDA and LHP levels. Univariate analysis indicated that B-Pb was associated with decreased rTL (β =-0.0041; p = 0.0063) and that the association between B-Pb and rTL remained significant, even when adjusting for age (β = -0.0041; p = 0.0065) and in multivariable-adjusted model (β = -0.0042; p = 0.0063). In conclusion, occupational Pb exposure resulted in decreased rTL and may represent a mechanism that contributes to Pb-related diseases.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
Pawlas N,Płachetka A,Kozłowska A,Mikołajczyk A,Kasperczyk A,Dobrakowski M,Kasperczyk Sdoi
10.1177/0748233715601758subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1961-1970issue
12eissn
0748-2337issn
1477-0393pii
0748233715601758journal_volume
32pub_type
杂志文章abstract::The distribution of [14C]-malathion, an organophosphorus pesticide, in rats after intravenous, oral and dermal administration was carried out using electronic autoradiography of whole body sections of treated animals. The study indicated that a major difference in the disposition of [14C]-malathion occurred following ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300605
更新日期:1997-11-01 00:00:00
abstract::Recently, we have detailed a DNA alkaline unwinding assay (DAUA) that can be used to rapidly measure chemically induced strand breaks in mammalian cells (Daniel et al., 1985). In this paper we present further development of this assay, including: (1) studies on the relationship between DNA adducts and DNA strand break...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823378900500506
更新日期:1989-10-01 00:00:00
abstract::This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons wi...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379501100301
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:Various authors who studied the effects of aluminium (Al) exposure on the neurocognitive system in the last 30 years have reached different and often contradictory conclusions. The aim of this study is to help clarify the effects that the metal causes on cognitive ability in a group of naval welders exposed ...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712456062
更新日期:2014-05-01 00:00:00
abstract::Insulin resistance (IR) is recognized as a contributory factor for a variety of liver diseases. The present study investigates the susceptibility of liver to the toxic actions of carbon tetrachloride (CCl(4)) in a rat model of IR, induced by feeding a high-fructose diet (60 g/100 g) for 30 days. A sub-lethal dose of C...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709359273
更新日期:2010-03-01 00:00:00
abstract::Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233716653912
更新日期:2017-05-01 00:00:00
abstract::Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were invest...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233714552295
更新日期:2016-06-01 00:00:00
abstract::Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713498459
更新日期:2016-01-01 00:00:00
abstract::Environmental Impact Assessment is essentially a process comprising four elements: identification, prediction, evaluation, and monitoring. Properly conducted EIA studies can identify linkages between injurious events and/or activities and their damaging consequences. This aids in making the risk management decision. T...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379100700541
更新日期:1991-09-01 00:00:00
abstract::The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational S...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233708098126
更新日期:2008-09-01 00:00:00
abstract::The purpose of this study was to describe for asthmatic subjects the distribution of individual bronchial sensitivity to sulfur dioxide (SO2). Subjects were nonsmoking male asthmatics (n = 27) who were sensitive to inhaled methacholine. None of the subjects used corticosteroids or cromolyn sodium. Oral medications wer...
journal_title:Toxicology and industrial health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/074823378600200307
更新日期:1986-09-01 00:00:00
abstract::As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These pro...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233708090910
更新日期:2008-06-01 00:00:00
abstract::Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating impor...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/0748233719898989
更新日期:2020-01-01 00:00:00
abstract::Forty-nine female workers in the shoemaking industry, exposed to a solvent mixture containing benzene and twenty-seven non-exposed controls, were investigated. Concentrations of benzene and toluene in the working atmosphere, as well as benzene and toluene in blood and phenols in pre- and post-shift urine as parameters...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300402
更新日期:1997-07-01 00:00:00
abstract::The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic, nuclear receptor that is responsible for the early events involved in the transcription of a complex set of genes comprising the CYP450 gene family. In the present computational study, homology modelling and molecular docking were carried out with...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233712463774
更新日期:2014-09-01 00:00:00
abstract::Retinyl esters are the storage form of vitamin A in skin, and retinyl palmitate (RP) accounts for the majority of the retinyl esters endogenously formed in skin. RP is also obtained exogenously through the topical application of cosmetic and skin care products that contain RP. There is limited information on the penet...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233706th253oa
更新日期:2006-05-01 00:00:00
abstract::Malathion can be ingested, inhaled, or absorbed through the skin, but acute toxicity is maximized when administered orally. Intravenous lipid emulsion (ILE) treatment is used as a new therapeutic method in cases of systemic toxicity caused by some lipid soluble agents. This study aimed to examine the potential treatme...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233717748080
更新日期:2018-02-01 00:00:00
abstract::Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genoto...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233715599472
更新日期:2016-12-01 00:00:00
abstract::This study reports on airborne exposure levels and soil concentrations of lead in regard to abatement of a steel structure (water tank). The tank was de-leaded by abrasive sand blasting. The ball of the tank had a lead surface level that exceeded the Environmental Protection Agency (EPA) definition of lead-based paint...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1191/0748233702th127oa
更新日期:2002-02-01 00:00:00
abstract::Male infertility can be caused by environmental factors, genetic defects, physiological and endocrine deficiencies and testicular pathologies. Aluminium (Al) can cause male infertility through a number of mechanisms. The aim of our study was thus to determine whether vitamin E (VitE) has protective effects on Al-induc...
journal_title:Toxicology and industrial health
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doi:10.1177/0748233720919663
更新日期:2020-04-01 00:00:00
abstract::In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713483205
更新日期:2015-10-01 00:00:00
abstract::The objective of this study was to examine the potential of arsenate to induce cardiomyocyte cell death and to explore the cellular mechanisms of arsenate toxicity. Isolated cardiomyocytes in culture from embryonic chick hearts were treated with a pentavalent arsenic species (H3AsO4) or arsenate. Arsenate produced a s...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233709105593
更新日期:2009-04-01 00:00:00
abstract::Two prospective, longitudinal studies-one in North Carolina and one in Michigan-have examined effects of prenatal polychlorinated biphenyl (PCB) exposure on behavioral and cognitive development in infants and children. The Michigan cohort was selected to overrepresent the offspring of women who had eaten relatively la...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379601200315
更新日期:1996-05-01 00:00:00
abstract::In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and to...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713500822
更新日期:2016-02-01 00:00:00
abstract::This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713501366
更新日期:2016-03-01 00:00:00
abstract::The effects of different methylmercury (MeHg) forms on the immune system and the hypothalamic pituitary adrenal (HPA) axis were assessed. The lymphocyte response to Concanavalin A (Con A) stimulation, blood levels of interleukin-6 (IL-6), adrenocorticotrophin hormone (ACTH), and corticosterone in the presence of diffe...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/074823379701300105
更新日期:1997-01-01 00:00:00
abstract::The concentrations of heavy metals (cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn)) were measured in hepatopancreas and muscle of a commercial shrimp (Metapenaeus affinis), in the muscle, liver and gills of two fish species (Thryssa vitrirostris and Johnius belangerii) and in the sediment samples take...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233713475498
更新日期:2015-06-01 00:00:00
abstract::An analytical method using natural analcime zeolite modified with tppz (2,3,5,6-tetra-pyridylpyrazine) for preconcentration of cadmium, in a column system, and their sequential determination by flame atomic absorption spectrometry (FAAS), was developed. In this work, cadmium was adsorbed onto natural analcime zeolite ...
journal_title:Toxicology and industrial health
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doi:10.1177/0748233711422730
更新日期:2012-10-01 00:00:00
abstract::The aim of this study was to evaluate indoor air quality and factors affecting expired carbon monoxide (CO) levels in a coffeehouse environment. This cross-sectional study was conducted at 16 randomly selected coffeehouses in Duzce, Turkey, during November 2007 to March 2008. A total of 547 people, average age 46.72 ±...
journal_title:Toxicology and industrial health
pub_type: 杂志文章
doi:10.1177/0748233710383888
更新日期:2011-04-01 00:00:00
abstract::The rabbit eye irritation test based on the Draize method is required for the hazard assessment of chemicals and products that may come into contact with the eye. Due to the potential for the suffering of animals and subjectivity of the test, many modifications of the method have been made that involved a reduction in...
journal_title:Toxicology and industrial health
pub_type: 杂志文章,评审
doi:10.1177/074823379300900602
更新日期:1993-11-01 00:00:00