Insulin resistance induced by high-fructose diet potentiates carbon tetrachloride hepatotoxicity.

abstract：:Adult female Swiss Webster and B6C3F1 mice received distilled water only or water containing 0.1, 1.0, 10, 100 or 1000 ppb of aldicarb daily for 34 days. The target concentration of aldicarb present in the 10 ppb dosing solution was analytically verified on a daily basis as was its stability over a 48-hr period. To de...

journal_title：Toxicology and industrial health

authors： Thomas PT,Ratajczak HV

更新日期：1988-09-01 00:00:00

abstract：:Using the Environmental Exposure and Sensitivity Inventory (EESI), a standardized instrument for measuring chemical sensitivity, we obtained and compared ratings of symptoms, chemical (inhalant) intolerances, other intolerances (e.g., drugs, caffeine, alcohol, skin contactants), lifeimpact, and masking (ongoing exposu...

journal_title：Toxicology and industrial health

authors： Miller CS,Prihoda TJ

更新日期：1999-04-01 00:00:00

abstract：:Changes in Lys- and Leu-aminopeptidase activities in several brain regions of the rat, after acute toluene administration, are described in this research. Aminopeptidase activity has been suggested as a candidate regulator of the degradation of several neuroactive peptides. Lys-aminopeptidase activity was significantl...

journal_title：Toxicology and industrial health

authors： De Gandarias JM,Echevarria E,Irazusta J,Casis E,Casis L

更新日期：1993-05-01 00:00:00

abstract：:The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight ora...

journal_title：Toxicology and industrial health

authors： Çelik MS,Güven K,Akpolat V,Akdağ MZ,Nazıroğlu M,Gül-Güven R,Çelik MY,Erdoğan S

更新日期：2015-06-01 00:00:00

abstract：:This study was designed to determine if long-term exposure to high doses of methoxychlor (M) would alter pituitary or testicular endocrine functions in either an estrogenic or antiandrogenic manner. Weanling male Long-Evans hooded rats were dosed daily with M (po) at 0, 200, 300, or 400 mg kg-1 day-1 for 10 months. Me...

journal_title：Toxicology and industrial health

authors： Gray LE Jr,Ostby J,Cooper RL,Kelce WR

更新日期：1999-01-01 00:00:00

abstract：:Endocrine disrupting chemicals (EDCs) are defined as exogenous substances that can alter the development and functioning of the endocrine system. The Wnt signaling pathway is an evolutionarily conserved pathway consisting of proteins that transmit cell-to-cell receptors through cell surface receptors, regulating impor...

journal_title：Toxicology and industrial health

authors： Üstündağ ÜV,Emekli-Alturfan E

更新日期：2020-01-01 00:00:00

abstract：:The hypolipidemic effect of 10% fruit fibers in rats fed with high-fat diet (HFD) was evaluated. This study was conducted on a total of 50 male Albino rats divided into 10 equal groups fed with different types of dietary fruits. The feeding period lasted for 24 weeks. Fasting blood samples were collected and sera sepa...

journal_title：Toxicology and industrial health

authors： Esmael OA,Sonbul SN,Kumosani TA,Moselhy SS

更新日期：2015-03-01 00:00:00

abstract：:The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rat...

journal_title：Toxicology and industrial health

authors： Ghorbel I,Elwej A,Chaabene M,Boudawara O,Marrakchi R,Jamoussi K,Boudawara TS,Zeghal N

更新日期：2017-08-01 00:00:00

abstract：:In the framework of a series of experiments conducted to evaluate the carcinogenic effects of oxygenated gasoline additives, MTBE was analyzed in an oral lifetime carcinogenicity study using 8-week-old male and female Sprague-Dawley rats. These experiments were part of a large research project on gasoline carcinogenic...

journal_title：Toxicology and industrial health

authors： Belpoggi F,Soffritti M,Maltoni C

更新日期：1995-03-01 00:00:00

abstract：:The distribution of [14C]-malathion, an organophosphorus pesticide, in rats after intravenous, oral and dermal administration was carried out using electronic autoradiography of whole body sections of treated animals. The study indicated that a major difference in the disposition of [14C]-malathion occurred following ...

journal_title：Toxicology and industrial health

authors： Saleh MA,Ahmed AE,Kamel A,Dary C

更新日期：1997-11-01 00:00:00

abstract：:Several classes of environmental contaminants have been claimed or suggested to possess endocrine-disrupting potency, which may result in reproductive problems and developmental disorders. In this paper the focus is on the multiple and interactive mechanisms of interference of persistent polyhalogenated aromatic hydro...

journal_title：Toxicology and industrial health

authors： Brouwer A,Morse DC,Lans MC,Schuur AG,Murk AJ,Klasson-Wehler E,Bergman A,Visser TJ

更新日期：1998-01-01 00:00:00

abstract：:The main objective of this study is to calculate the hours of diving in benzene-polluted waters acceptable for professional divers. We considered recommended absorption limit as that from pulmonary workplace absorption during an 8-h workday at recommended exposure limits set by the National Institute of Occupational S...

journal_title：Toxicology and industrial health

authors： Froom P

更新日期：2008-09-01 00:00:00

abstract：:The risk assessment process must encompass all available toxicological data and scientific evidence on the plausible toxicities of a chemical or chemical mixture. As an extension to the approaches used to conduct risk assessments on chemical mixtures, a preliminary scheme, analogous to the IARC classification of carci...

journal_title：Toxicology and industrial health

authors： Mumtaz MM,Durkin PR

更新日期：1992-11-01 00:00:00

abstract：:Maneb is a dithiocarbamate fungicide that contains manganese. Dithiocarbamates are considered to be chemicals of low toxicity. An experimental group (n = 10) received maneb (obtained from Hoecht-Shering) at a concentration of 250 ppm in distilled water five days a week (treatment time is three weeks). It was orally ad...

journal_title：Toxicology and industrial health

authors： Deveci E

更新日期：2006-10-01 00:00:00

abstract：:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...

journal_title：Toxicology and industrial health

authors： Aly HA,Hassan MH,El-Beshbishy HA,Alahdal AM,Osman AM

更新日期：2016-08-01 00:00:00

abstract：:In response to reported increased cancer risks among farmers, the Agricultural Health Study (AHS) was designed to examine health outcomes and environmental exposures among farm families in the United States. In the pilot phase of the AHS, food, beverage, air, dermal, dust, surface wipe, and biological specimens (blood...

journal_title：Toxicology and industrial health

authors： Brock JW,Melnyk LJ,Caudill SP,Needham LL,Bond AE

更新日期：1998-01-01 00:00:00

abstract：:A meta-analysis of epidemiologic studies for textile industry workers was undertaken in an attempt to evaluate whether the cancer risk varies within the textile industry in relation to the job held or the textile fiber used. We combined studies published up until 1990, when an ad hoc IARC Monograph was issued, and tho...

journal_title：Toxicology and industrial health

authors： Mastrangelo G,Fedeli U,Fadda E,Milan G,Lange JH

更新日期：2002-05-01 00:00:00

abstract：:Chronic exposure to jet fuel has been shown to have adverse effects on human liver function, to cause emotional dysfunction, to cause abnormal electroencephalograms, to cause shortened attention spans, and to decrease sensorimotor speed. Due to the decision by the United States Air Force to implement the widespread us...

journal_title：Toxicology and industrial health

authors： Harris DT,Sakiestewa D,Robledo RF,Witten M

更新日期：1997-09-01 00:00:00

abstract：:Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...

journal_title：Toxicology and industrial health

authors： Alm-Eldeen AA,Mona MH,Shati AA,El-Mekkawy HI

更新日期：2015-12-01 00:00:00

abstract：:'Toxicant-induced loss of tolerance' (or TILT) describes a two-step disease process in which (1) certain chemical exposures, e.g., indoor air contaminants, chemical spills, or pesticide applications, cause certain susceptible persons to lose their prior natural tolerance for common chemicals, foods, and drugs (initiat...

journal_title：Toxicology and industrial health

authors： Miller CS

更新日期：1999-04-01 00:00:00

abstract：:The bromoalkane, 1-bromopropane (1-BP), may damage the reproductive system though oxidative stress, while the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays an important role in regulating intracellular antioxidant levels against oxidative stress. This study explored the role of oxidativ...

journal_title：Toxicology and industrial health

authors： Yang G,Xiang Y,Zhou W,Zhong X,Zhang Y,Lin D,Huang X

更新日期：2020-12-11 00:00:00

abstract：:Yoghurt is a popular dairy product in Iran because of its beneficial influence on human health and nutritional value. Aflatoxin M1 (AFM1) is the metabolite of potential carcinogen aflatoxin B1, which can contaminate milk through the feed and is not eliminated by common processing heat treatment. An analytical method u...

journal_title：Toxicology and industrial health

authors： Tabari M,Karim G,Ghavami M,Chamani M

更新日期：2011-08-01 00:00:00

abstract：:In summary, we have described our method of treating phosgene inhalation injury. We have presented two serious cases in detail which demonstrate that survival was associated with aggressive therapy. Several points should be mentioned. The pulmonary edema and resulting fluid and foam production can be so copious as to ...

journal_title：Toxicology and industrial health

authors： Regan RA

更新日期：1985-10-01 00:00:00

abstract：:The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

journal_title：Toxicology and industrial health

authors： Ahbab MA,Barlas N,Karabulut G

更新日期：2017-02-01 00:00:00

abstract：:Excessive exposure to nickel may cause health effects on the blood, lung, nose, kidney, reproductive system, skin and the unborn child. In the present study, we found that Ni²⁺ exposure led to a time- and dose-dependent proliferation arrest and death in human leukemia HL-60 cells. In the presence of 1 mM Ni²⁺, reactiv...

journal_title：Toxicology and industrial health

authors： Chen J,Han J,Wang J

更新日期：2013-05-01 00:00:00

abstract：:The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifesty...

journal_title：Toxicology and industrial health

authors： Silva-Júnior FMRD,Tavella RA,Fernandes CLF,Mortola AS,Peraza GG,Garcia EM

更新日期：2020-05-01 00:00:00

abstract：:The assessment of risk due to environmental contaminants depends, in part, on scientific data. When such data are incomplete, as is usually the case, assumptions based on scientific judgments are made to analyze the consequences. Specifically, when health related data needed to assess the risk posed by environmental c...

journal_title：Toxicology and industrial health

authors： Cothern CR

更新日期：1989-05-01 00:00:00

abstract：:Hepato-toxicity of cadmium in alloxan induced diabetic rats has been studied by estimating a few enzymes viz serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and gamma-glutamyltranspeptidase. Present results suggest that cadmium manifests different effects in normal and diabe...

journal_title：Toxicology and industrial health

authors： Rana SV,Rastogi N

更新日期：1998-05-01 00:00:00

abstract：:In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...

journal_title：Toxicology and industrial health

authors： Ullah N,Haq IU,Safdar N,Mirza B

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Various authors who studied the effects of aluminium (Al) exposure on the neurocognitive system in the last 30 years have reached different and often contradictory conclusions. The aim of this study is to help clarify the effects that the metal causes on cognitive ability in a group of naval welders exposed ...

journal_title：Toxicology and industrial health

authors： Giorgianni CM,D'Arrigo G,Brecciaroli R,Abbate A,Spatari G,Tringali MA,Gangemi S,De Luca A

更新日期：2014-05-01 00:00:00