Abstract:
:Changes in Lys- and Leu-aminopeptidase activities in several brain regions of the rat, after acute toluene administration, are described in this research. Aminopeptidase activity has been suggested as a candidate regulator of the degradation of several neuroactive peptides. Lys-aminopeptidase activity was significantly decreased in the thalamus, amygdala, and medulla oblongata. Leu-aminopeptidase activity was significantly decreased in the thalamus and cerebellum. It is suggested that these aminopeptidase activities could play a part in the mechanism of toluene neurotoxicity.
journal_name
Toxicol Ind Healthjournal_title
Toxicology and industrial healthauthors
De Gandarias JM,Echevarria E,Irazusta J,Casis E,Casis Ldoi
10.1177/074823379300900310subject
Has Abstractpub_date
1993-05-01 00:00:00pages
511-7issue
3eissn
0748-2337issn
1477-0393journal_volume
9pub_type
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