Lys- and Leu-aminopeptidase activity after acute toluene exposure in the rat brain.

Abstract:

:Changes in Lys- and Leu-aminopeptidase activities in several brain regions of the rat, after acute toluene administration, are described in this research. Aminopeptidase activity has been suggested as a candidate regulator of the degradation of several neuroactive peptides. Lys-aminopeptidase activity was significantly decreased in the thalamus, amygdala, and medulla oblongata. Leu-aminopeptidase activity was significantly decreased in the thalamus and cerebellum. It is suggested that these aminopeptidase activities could play a part in the mechanism of toluene neurotoxicity.

journal_name

Toxicol Ind Health

authors

De Gandarias JM,Echevarria E,Irazusta J,Casis E,Casis L

doi

10.1177/074823379300900310

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

511-7

issue

3

eissn

0748-2337

issn

1477-0393

journal_volume

9

pub_type

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