Possible peripheral markers for chronic aluminium toxicity in Wistar rats.

Abstract:

:This investigation gives detailed analysis of peripheral marker enzymes as well as neurobehavioral tests following chronic aluminium (Al) exposure (10 mg/kg b.w. for 12 weeks intragastrically). We observed a significant decrease in the levels of serum cholinesterase after toxicity. The enzymatic activity of cytochrome oxidase (CO), the terminal enzyme of the electron transport chain, was significantly diminished and that of glucose-6-phosphate dehydrogenase (G-6-PD) was significantly enhanced. Neuromuscular co-ordination was assessed using motor and memory function tests. Deficits were observed suggesting a probable model for chronic Al neurotoxicity.

journal_name

Toxicol Ind Health

authors

Kaur A,Gill KD

doi

10.1191/0748233706th242oa

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

39-46

issue

1

eissn

0748-2337

issn

1477-0393

journal_volume

22

pub_type

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