Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency.

abstract：:This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

journal_title：International journal of hematology

authors： Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

更新日期：2017-04-01 00:00:00

abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

journal_title：International journal of hematology

authors： Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...

journal_title：International journal of hematology

authors： Gotoh N,Saitoh T,Takahashi N,Kasamatsu T,Minato Y,Lobna A,Oda T,Hoshino T,Sakura T,Shimizu H,Takizawa M,Handa H,Yokohama A,Tsukamoto N,Murakami H

更新日期：2018-09-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...

journal_title：International journal of hematology

authors： Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki M

更新日期：2009-04-01 00:00:00

abstract：:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

journal_title：International journal of hematology

authors： Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

更新日期：2011-12-01 00:00:00

abstract：:A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

journal_title：International journal of hematology

authors： Kondo H,Date Y

更新日期：1997-02-01 00:00:00

abstract：:By means of a mail questionnaire, we evaluated the influence of treatment for acute leukemia on offspring of long-term survivors and determined whether the outcome of pregnancy in patients (or spouses) induced relapse of acute leukemia. In 322 replies from the 445 institutions where a questionnaire was sent, there wer...

journal_title：International journal of hematology

authors： Kawamura S,Suzuki Y,Tamai Y,Itoh J,Fukushima K,Takami H,Yoshida Y,Sawada Y,Sakata Y

更新日期：1995-10-01 00:00:00

abstract：:We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

journal_title：International journal of hematology

authors： Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

更新日期：2007-07-01 00:00:00

abstract：:The objective of this study is to analyze the clinical characteristics and treatment of patients with primary non-Hodgkin's lymphoma of the breast (PNHLB). Forty-five patients with PNHLB treated in our hospital during a 15-year period were retrospectively analyzed. Forty-four were females and one male, with a median a...

journal_title：International journal of hematology

authors： Guo HY,Zhao XM,Li J,Hu XC

更新日期：2008-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers,...

journal_title：International journal of hematology

authors： Ikeda S,Tagawa H

更新日期：2014-01-01 00:00:00

abstract：:The paradox of myelodysplastic syndromes (MDS) which present with pancytopenias despite cellular bone marrows (BM) was investigated by conducting detailed studies of proliferation and apoptosis in 89 MDS patients. Our results demonstrated a rapid rate of both proliferation as well as apoptosis. Levels of three cytokin...

journal_title：International journal of hematology

authors： Raza A,Mundle S,Shetty V,Alvi S,Chopra H,Span L,Parcharidou A,Dar S,Venugopal P,Borok R,Gezer S,Showel J,Loew J,Robin E,Rifkin S,Alston D,Hernandez B,Shah R,Kaizer H,Gregory S

更新日期：1996-06-01 00:00:00

abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

journal_title：International journal of hematology

authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

更新日期：2016-12-01 00:00:00

abstract：:The relative risk of non-Hodgkin's lymphoma (NHL) among patients infected with human immunodeficiency virus (HIV) is elevated compared with the general population. We describe a retrospective study of 78 HIV-infected patients with NHL treated between 1999 and 2006 at the Infectology Institute, a reference center for H...

journal_title：International journal of hematology

authors： Tanaka PY,Pracchia LF,Calore EE

更新日期：2006-11-01 00:00:00

abstract：:Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...

journal_title：International journal of hematology

authors： Ichikawa M,Yoshimi A,Nakagawa M,Nishimoto N,Watanabe-Okochi N,Kurokawa M

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:While perfluorocarbons (PFCs) may be useful in some clinical situations, previous studies have shown that interferences with chemistry analytes can occur with blood samples containing PFCs. This in vitro study focused on how the PFC Oxycyte may affect hematology measurements in blood samples. Swine blood dil...

journal_title：International journal of hematology

authors： Arnaud F,Sanders K,Sieckmann D,Moon-Massat P

更新日期：2016-05-01 00:00:00

abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

journal_title：International journal of hematology

authors： Nakao S,Feng X,Sugimori C

更新日期：2005-10-01 00:00:00

abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

journal_title：International journal of hematology

authors： Yano K,Iijima K,Sao H,Kobayashi M

更新日期：1996-10-01 00:00:00

abstract：:Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...

journal_title：International journal of hematology

authors： Sashida G,Iwama A

更新日期：2017-01-01 00:00:00

abstract：:A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

journal_title：International journal of hematology

authors： Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

更新日期：1991-12-01 00:00:00

abstract：:Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow a...

journal_title：International journal of hematology

authors： Chien CC,Chiou TJ,Lee MY,Hsiao LT,Kwang WK

更新日期：2004-05-01 00:00:00

abstract：:The receptor for macrophage colony-stimulating factor (M-CSF) is expressed in monocytes/macrophages and their progenitor cells and stimulates both the growth and development of the blood-cell lineage. Although the specific components positively regulating M-CSF receptor signaling have been relatively well defined, it ...

journal_title：International journal of hematology

authors： Suzu S,Motoyoshi K

更新日期：2002-07-01 00:00:00

abstract：:Peripheral T-cell lymphoma (PTCL) is a neoplastc disease of peripheral T-lymphocytes/NK cells, including PTCL unspecified, anaplastic large T-cell lymphoma (ALCL), IBL-like T-cell lymphoma (AILD), intestinal T-cell lymphoma (ITCL) and adult T-cell leukemia/lymphoma (ATL). The incidence of PTCL is relatively uncommon a...

journal_title：International journal of hematology

authors： Matsuoka M

更新日期：2002-08-01 00:00:00

abstract：:We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...

journal_title：International journal of hematology

authors： Houwing ME,Koopman-Coenen EA,Kersseboom R,Gooskens S,Appel IM,Arentsen-Peters ST,de Vries AC,Reinhardt D,Stary J,Baruchel A,de Haas V,Blink M,Lopes Cardozo RH,Pieters R,Michel Zwaan C,van den Heuvel-Eibrink MM

更新日期：2015-07-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...

journal_title：International journal of hematology

authors： Nishio N,Kojima S

更新日期：2010-10-01 00:00:00

abstract：:We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reactio...

journal_title：International journal of hematology

authors： Sue YC,Liu TC,Chang CS,Huang SM,Chen TP,Lin SF

更新日期：1999-04-01 00:00:00

abstract：:Natural killer (NK)/T-cell lymphoma associated with Epstein-Barr virus (EBV) in a patient infected with human immunodeficiency virus (HIV) is very rare. The authors encountered a case of NK/T-cell lymphoma in a 36-year-old man who presented with an ulcerative mass on both tonsils. During assessment, HIV positivity was...

journal_title：International journal of hematology

authors： Oh SC,Choi CW,Kim BS,Shin SW,Kim YH,Lee JS,Kim MJ,Jung WY,Kim HK,Yeom BW,Kim IS,Kim JS

更新日期：2004-06-01 00:00:00

abstract：:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the c...

journal_title：International journal of hematology

authors： Imamura T,Matsuo S,Yoshihara T,Chiyonobu T,Mori K,Ishida H,Nishimura Y,Kasubuchi Y,Naya M,Morimoto A,Hibi S,Imashuku S

更新日期：2004-08-01 00:00:00

abstract：:CD21 is a 145-kDa membrane glycoprotein mainly expressed on B cells and follicular dendritic cells, and is involved in B-cell activation, survival and proliferation. CD21 can be cleaved to give soluble CD21 (sCD21), which is constantly shed in healthy persons. We show here that plasma sCD21 levels are higher, while B-...

journal_title：International journal of hematology

authors： Low HZ,Hilbrans D,Schmidt-Wolf IG,Illges H

更新日期：2012-09-01 00:00:00

abstract：:The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related...

journal_title：International journal of hematology

authors： Yabumoto K,Ohno H,Doi S,Edamura S,Arita Y,Akasaka T,Matsumoto J,Kadowaki N,Fukuhara S,Okuma M

更新日期：1994-04-01 00:00:00