Benefit of simultaneous rhG-CSF and methylprednisolone 'pulse' therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis.

abstract：:We studied a 29-year-old Japanese male patient with factor XI deficiency; we also studied his parents and one sibling. Factor XI coagulation activity and antigen levels were extremely low (less than 1% of normal level) in both the patient and his brother, and they were half the normal levels in both parents. Sequence ...

journal_title：International journal of hematology

authors： Kawaguchi T,Koga S,Hongo H,Komiyama Y,Li K,Ishihara S,Horikawa K,Hidaka M,Mitsuya H,Nakakuma H

更新日期：2000-01-01 00:00:00

abstract：:GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiatio...

journal_title：International journal of hematology

authors： Harigae H,Okitsu Y,Yokoyama H,Fujiwara T,Inomata M,Takahashi S,Minegishi N,Kaku M,Sasaki T

更新日期：2006-07-01 00:00:00

abstract：:We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...

journal_title：International journal of hematology

authors： Nakano T

更新日期：1996-12-01 00:00:00

abstract：:The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...

journal_title：International journal of hematology

authors： Choi YW,Ahn MS,Choi JH,Lee HW,Kang SY,Jeong SH,Park JS,Han JH,Kim JH,Sheen SS

更新日期：2016-02-01 00:00:00

abstract：:The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene is a favorable progno...

journal_title：International journal of hematology

authors： Hiraga J,Kinoshita T,Ohno T,Mori N,Ohashi H,Fukami S,Noda A,Ichikawa A,Naoe T

更新日期：2006-10-01 00:00:00

abstract：:The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evaluation of response to ATRA treatment, lymphocytes must be excluded as they do not originally have t(15;17). ...

journal_title：International journal of hematology

authors： Sato K,Sakai H,Saiki Y,Uchida A,Uemura Y,Yokoi S,Tsuruoka Y,Nishio Y,Matsunawa M,Suzuki Y,Isobe Y,Kato M,Tomita N,Inoue Y,Miura I

更新日期：2018-09-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:We evaluated the efficacy and safety of switching to nilotinib in CML-CP patients who had achieved MMR with continuous detectable BCR-ABL1 transcript levels after long-term imatinib treatment. Patients who had achieved MMR, but not deep molecular response (DMR), after > 18 months from the initiation of imatinib receiv...

journal_title：International journal of hematology

authors： Ishikawa J,Matsumura I,Kawaguchi T,Kuroda J,Nakamae H,Miyamoto T,Matsuoka KI,Shibayama H,Hino M,Hirase C,Kamimura T,Shimose T,Akashi K,Kanakura Y

更新日期：2018-05-01 00:00:00

abstract：:We have demonstrated that adipose tissue-derived mesenchymal stem cells (ADSCs) from mice are capable of reconstituting the hematopoietic microenvironment, and facilitate hematopoiesis more effectively than bone marrow-derived mesenchymal stem cells (BMSCs) in mouse. The ready accessibility of fat tissue rich in MSCs ...

journal_title：International journal of hematology

authors： Nishiwaki S,Nakayama T,Saito S,Mizuno H,Ozaki T,Takahashi Y,Maruyama S,Nishida T,Murata M,Kojima S,Naoe T

更新日期：2012-09-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) conditions appear to be the best possible candidates for a gene therapy approach. Transgene expression by lymphocyte precursors should confer to these cells a selective growth advantage that gives rise to long-lived T-lymphocytes. This rationale was used as a basis for a clinica...

journal_title：International journal of hematology

authors： Hacein-Bey-Abina S,Fischer A,Cavazzana-Calvo M

更新日期：2002-11-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

journal_title：International journal of hematology

authors： Takaori-Kondo A

更新日期：2006-04-01 00:00:00

abstract：:To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

journal_title：International journal of hematology

authors： Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

更新日期：1992-06-01 00:00:00

abstract：:We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m2) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and c...

journal_title：International journal of hematology

authors： Fujii N,Maeda Y,Takenaka K,Shinagawa K,Imai T,Kozuka T,Ikeda K,Sunami K,Hiramatsu Y,Ishimaru F,Niiya K,Harada M

更新日期：2000-12-01 00:00:00

abstract：:The present study (ClinicalTrials.gov Identifier: NCT02221492) was conducted to assess the efficacy and safety of plerixafor for the mobilization and collection of haematopoietic stem cells (HSCs) for autologous transplantation in Japanese non-Hodgkin lymphoma (NHL) patients. In this randomized phase 2 study, patients...

journal_title：International journal of hematology

authors： Matsue K,Kumagai K,Sugiura I,Ishikawa T,Igarashi T,Sato T,Uchiyama M,Miyamoto T,Ono T,Ueda Y,Kiguchi T,Sunaga Y,Sasaki T,Suzuki K

更新日期：2018-11-01 00:00:00

abstract：:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

journal_title：International journal of hematology

authors： Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

更新日期：2019-06-01 00:00:00

abstract：:We constructed a "biomimetic osteoblast niche" with bio-derived bone as a scaffold, on which we seeded marrow mesenchymal stem cells (MSCs) from CML patients, and induced the MSCs to differentiate into osteoblasts. Bone marrow mononuclear cells from CML patients were cultured in the biomimetic niche (3D culture system...

journal_title：International journal of hematology

authors： Hou L,Liu T,Tan J,Meng W,Deng L,Yu H,Zou X,Wang Y

更新日期：2009-10-01 00:00:00

abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterized by an extreme susceptibility to Epstein-Barr virus (EBV) infection. Patients with XLP mainly present with the 3 clinical manifestations of fulminant infectious mononucleosis, lymphoproliferative disorder, and dysgammaglobulinemia...

journal_title：International journal of hematology

authors： Hoshino T,Kanegane H,Doki N,Irisawa H,Sakura T,Nojima Y,Miyawaki S,Miyawaki T

更新日期：2005-07-01 00:00:00

abstract：:Detection of autoantibodies to erythrocytes is of fundamental importance in the diagnosis of autoimmune hemolytic anemia (AIHA). The routinely used direct antiglobulin test (DAT) has the disadvantage of low sensitivity. In this study, we investigated the optimal test conditions of measurement of red blood cell (RBC)-b...

journal_title：International journal of hematology

authors： Wang Z,Shi J,Zhou Y,Ruan C

更新日期：2001-02-01 00:00:00

abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

journal_title：International journal of hematology

authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

更新日期：2011-04-01 00:00:00

abstract：:A 76-year-old Japanese woman was hospitalized for ileus symptoms caused by extensive thrombosis of the superior mesenteric vein. Because laboratory test results suggested type III protein S (PS) deficiency, molecular changes in PS were investigated. A single-base transition, CCG to CTG at codon 626 in exon XV, resulti...

journal_title：International journal of hematology

authors： Kato M,Iida S,Sato M,Hayami Y,Hanamura I,Miura K,Ito M,Harada S,Komatsu H,Wakita A,Manabe T,Ueda R

更新日期：2002-01-01 00:00:00

abstract：:According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

journal_title：International journal of hematology

authors： Zoi K,Cross NC

更新日期：2015-03-01 00:00:00

abstract：:TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Suc...

journal_title：International journal of hematology

authors： Tan TK,Zhang C,Sanda T

更新日期：2019-01-01 00:00:00

abstract：:Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underw...

journal_title：International journal of hematology

authors： Nakaseko C,Ozawa S,Sakaida E,Sakai M,Kanda Y,Oshima K,Kurokawa M,Takahashi S,Ooi J,Shimizu T,Yokota A,Yoshiba F,Fujimaki K,Kanamori H,Sakai R,Saitoh T,Sakura T,Maruta A,Sakamaki H,Okamoto S

更新日期：2011-03-01 00:00:00

abstract：:We report an infant with autoimmune neutropenia (AIN), idiopathic thrombocytopenia (ITP), and IgG2/IgA deficiency. The patient was referred to our hospital at 5 months of age because of epistaxis and generalized petechiae. Physical examination revealed moderate hepatosplenomegaly. A complete blood count revealed a pla...

journal_title：International journal of hematology

authors： Sugita K,Owada Y,Ozawa T,Sakakibara H,Eguchi M,Furukawa T,Saitoh K

更新日期：1993-01-01 00:00:00

abstract：:The wild-type Wilms tumor gene, WT1, is overexpressed in myelodysplastic syndrome (MDS) as well as acute myeloid leukemia. In a phase I clinical trial of biweekly vaccination with HLA-A*2402-restricted WT1 peptide for these malignancies, 2 patients with MDS developed severe leukocytopenia in association with a reducti...

journal_title：International journal of hematology

authors： Kawakami M,Oka Y,Tsuboi A,Harada Y,Elisseeva OA,Furukawa Y,Tsukaguchi M,Shirakata T,Nishida S,Nakajima H,Morita S,Sakamoto J,Kawase I,Oji Y,Sugiyama H

更新日期：2007-06-01 00:00:00

abstract：:We evaluated the efficacy of systemic high-dose methotrexate (HD-MTX) for CNS prophylaxis in a prospectively recruited cohort of DLBCL patients at high risk of CNS relapse. High-risk CNS relapse was defined as the involvement of ≥ 2 extranodal sites with elevated lactate dehydrogenase (LDH); CNS international prognost...

journal_title：International journal of hematology

authors： Lee K,Yoon DH,Hong JY,Kim S,Lee K,Kang EH,Huh J,Park CS,Lee SW,Suh C

更新日期：2019-07-01 00:00:00

abstract：:A patient with chronic myelogenous leukemia (CML) in chronic phase (CP) had been treated with a syngeneic bone marrow transplantation (BMT). Cytogenetic remission was confirmed 3 months later. One year after transplantation, hematological remission persisted while cytogenetic analysis revealed a recurrence of Philadel...

journal_title：International journal of hematology

authors： Yano K,Iijima K,Sao H,Kobayashi M

更新日期：1996-10-01 00:00:00

abstract：:Perioperative hemostatic management is a challenge in patients with Glanzmann thrombasthenia (GT). The standard means of preventing surgical bleeding in GT patients is platelet transfusion. However, GT patients often possess alloantibodies against GPIIb/IIIa and/or HLA, which cause resistance to platelet transfusion. ...

journal_title：International journal of hematology

authors： Ogawa Y,Kunishima S,Yanagisawa K,Osaki Y,Uchiyama Y,Matsumoto N,Tokiniwa H,Horiguchi J,Nojima Y,Handa H

更新日期：2017-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old fe...

journal_title：International journal of hematology

authors： Matsukawa T,Goto H,Takahashi K,Asanuma S,Yasumoto A,Takahata M,Shigematsu A,Endo T,Tanaka J,Hashino S,Tanaka S,Imamura M

更新日期：2012-02-01 00:00:00