Long-term culture of leukemic bone marrow primary cells in biomimetic osteoblast niche.

abstract：:Autologous stem cell transplantation is considered the best post-induction therapy for multiple myeloma (MM). Therefore, therapy for myeloma should be chosen not only on the basis of efficacy, but also taking into account their impact on the hematopoietic stem cell compartment. We describe the case of a MM patient in ...

journal_title：International journal of hematology

authors： Giglio G,Romito S,Carrozza F,Musacchio M,Antuzzi G,Gigli R,Magri M,Bavaro P,Di Bartolomeo P,Dell'Isola M,Accorsi P

更新日期：2009-07-01 00:00:00

abstract：:Polycomb-group genes (PcG), identified by Drosophila genetics, are believed to maintain positional information by constituting a cellular memory system. Recently this system has been proved to be supported by epigenetic transcription regulation. PcG products comprise two distinct complexes, PcG complex 1 and 2. First ...

journal_title：International journal of hematology

authors： Takihara Y

更新日期：2008-01-01 00:00:00

abstract：:von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are express...

journal_title：International journal of hematology

authors： Nakayama T,Matsushita T,Yamamoto K,Mutsuga N,Kojima T,Katsumi A,Nakao N,Sadler JE,Naoe T,Saito H

更新日期：2008-05-01 00:00:00

abstract：:Fas stimulation has been reported to promote the activation and proliferation of T lymphocytes, but the intracellular signalling pathways that mediate non-apoptotic responses to Fas are poorly defined. To distinguish between the activation signalling and the death-inducing pathway downstream of Fas, we generated a nov...

journal_title：International journal of hematology

authors： Shin MJ,Shim JH,Lee JY,Chae WJ,Lee HK,Morio T,Park JH,Chang EJ,Lee SK

更新日期：2010-09-01 00:00:00

abstract：:Diffuse large-cell lymphoma (DLCL) is a neoplasm that is curable with chemotherapy in an appreciable percentage of patients. However, not all patients are cured and the best drug combination and optimal dose intensity have not yet been established. In an attempt to improve complete response rate and survival with mini...

journal_title：International journal of hematology

authors： Ohnoshi T,Hayashi K,Ueno K,Tada A,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Yoshino T

更新日期：1993-08-01 00:00:00

abstract：:The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 ...

journal_title：International journal of hematology

authors： Tachibana T,Kanda J,Machida S,Saito T,Tanaka M,Najima Y,Koyama S,Miyazaki T,Yamamoto E,Takeuchi M,Morita S,Kanda Y,Kanamori H,Okamoto S,Kanto Study Group for Cell Therapy (KSGCT).

更新日期：2018-05-01 00:00:00

abstract：:The XCIND syndrome is named after distinct hypersensitivity to ionizing (X-ray) irradiation, cancer susceptibility, immunodeficiency, neurological abnormality, and double-strand DNA breakage. The disorders comprising XCIND syndrome are usually inherited in an autosomal recessive manner. Ataxia telangiectasia (A-T) is ...

journal_title：International journal of hematology

authors： Mizutani S,Takagi M

更新日期：2013-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

journal_title：International journal of hematology

authors： Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

更新日期：2004-11-01 00:00:00

abstract：:Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...

journal_title：International journal of hematology

authors： Morita K,Yoshimi A,Masuda A,Ichikawa M,Yatomi Y,Kurokawa M

更新日期：2013-08-01 00:00:00

abstract：:Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...

journal_title：International journal of hematology

authors： Braggio E,Maiolino A,Gouveia ME,Magalhães R,Souto Filho JT,Garnica M,Nucci M,Renault IZ

更新日期：2010-01-01 00:00:00

abstract：:In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

journal_title：International journal of hematology

authors： Sheu JR,Hsiao G,Lee YM,Yen MH

更新日期：2001-04-01 00:00:00

abstract：:A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This...

journal_title：International journal of hematology

authors： Denčić-Fekete M,Đorđević V,Storlazzi CT,Janković G,Bogdanović A,Jovanović J,Rocchi M,Todorić-Živanović B,Strnad M,Gotić M

更新日期：2009-05-01 00:00:00

abstract：:We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

journal_title：International journal of hematology

authors： Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast. CASE REPORT:We describe the case of a 39-year-old woman ...

journal_title：International journal of hematology

authors： Bouzguenda R,Khanfir A,Toumi N,Chaaben K,Hentati Y,Ayadi L,Feki W,Daoud J,Frikha M

更新日期：2013-10-01 00:00:00

abstract：:Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in nor...

journal_title：International journal of hematology

authors： Zhang H

更新日期：2018-05-01 00:00:00

abstract：:The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evaluation of response to ATRA treatment, lymphocytes must be excluded as they do not originally have t(15;17). ...

journal_title：International journal of hematology

authors： Sato K,Sakai H,Saiki Y,Uchida A,Uemura Y,Yokoi S,Tsuruoka Y,Nishio Y,Matsunawa M,Suzuki Y,Isobe Y,Kato M,Tomita N,Inoue Y,Miura I

更新日期：2018-09-01 00:00:00

abstract：:We report 2 paroxysmal nocturnal hemoglobinuria (PNH) patients who were initially diagnosed with aplastic anemia and sequentially developed PNH, myelodysplastic syndromes (MDS), and leukemia. Flow cytometry and cytogenetic analysis showed the initial appearance and expansion of PNH clones, gradual replacement of PNH c...

journal_title：International journal of hematology

authors： Ishihara S,Nakakuma H,Kawaguchi T,Nagakura S,Horikawa K,Hidaka M,Asou N,Mitsuya H

更新日期：2000-08-01 00:00:00

abstract：:Waldenstroem's macroglobulinemia is usually closely related to a histopathologic subtype called lymphoplasmacytoid lymphoma in the Revised European-American Lymphoma (REAL) classification. Here, we report a case of B-cell lymphoma accompanied by monoclonal macroglobulinemia and pathologically compatible with marginal ...

journal_title：International journal of hematology

authors： Nakata M,Matsuno Y,Takenaka T,Kobayashi Y,Takeyama K,Yokozawa T,Tobinai K

更新日期：1997-06-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00

abstract：:We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...

journal_title：International journal of hematology

authors： Houwing ME,Koopman-Coenen EA,Kersseboom R,Gooskens S,Appel IM,Arentsen-Peters ST,de Vries AC,Reinhardt D,Stary J,Baruchel A,de Haas V,Blink M,Lopes Cardozo RH,Pieters R,Michel Zwaan C,van den Heuvel-Eibrink MM

更新日期：2015-07-01 00:00:00

abstract：:A new complicated Ph1 translocation involving five chromosomes, t(9;22;21;11;inv ins(12)-(q15p12p13))(q34;q11;q22;q13;q15), was found in a 64-year-old Korean woman with chronic myelocytic leukemia (CML). At presentation, the patient was found to be in the accelerated phase, she entered the chronic phase after six cycl...

journal_title：International journal of hematology

authors： Abe R,Shiga Y,Ookoshi T,Tanaka T,Maruyama Y

更新日期：1991-12-01 00:00:00

abstract：:Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

journal_title：International journal of hematology

authors： Kato M,Koh K,Kikuchi A,Hanada R

更新日期：2012-12-01 00:00:00

abstract：:To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...

journal_title：International journal of hematology

authors： Zhu H,Xu W,Liu H,Wang H,Fu R,Wu Y,Qu W,Wang G,Guan J,Song J,Xing L,Shao Z

更新日期：2016-05-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...

journal_title：International journal of hematology

authors： Ruscetti FW,Bartelmez SH

更新日期：2001-07-01 00:00:00

abstract：:Allogeneic stem cell transplantation is an established treatment modality for a variety of hematologic malignancies. Unfortunately it carries a high risk of complications and toxicities related to the intensive preparative regimen which is traditionally used for pre-transplant myeloablation and the graft versus host d...

journal_title：International journal of hematology

authors： Giralt S

更新日期：2002-08-01 00:00:00

abstract：:Collection and analysis of information on diseases and post-transplant courses of allogeneic hematopoietic stem cell transplant recipients have played important roles in improving therapeutic outcomes in hematopoietic stem cell transplantation. Efficient, high-quality data collection systems are essential. The introdu...

journal_title：International journal of hematology

authors： Atsuta Y

更新日期：2016-01-01 00:00:00

abstract：:Familial platelet disorder (FPD) is a rare autosomal dominant disorder which causes moderate thrombocytopenia with or without impaired platelet function. Patients have a propensity to develop acute myeloid leukemia (AML), and various types of second hits have been postulated in the evolution to AML. However, only a fe...

journal_title：International journal of hematology

authors： Nishimoto N,Imai Y,Ueda K,Nakagawa M,Shinohara A,Ichikawa M,Nannya Y,Kurokawa M

更新日期：2010-07-01 00:00:00

abstract：:The phenotypic distributions of observed numbers of ABO blood groups in a Kuwaiti sample population of 18,558 subjects are 4962 (26.7%) with A, 4,462 (24.1%) with B, 858 (4.6%) with AB, and 8,276 (44.6%) with 0. The calculated gene frequencies are 0.6678 for ABO*O, 0.1768 for ABO*A, and 0.1554 for ABO*B. Molecular gen...

journal_title：International journal of hematology

authors： Al-Bustan S,El-Zawahri M,Al-Azmi D,Al-Bashir AA

更新日期：2002-02-01 00:00:00

abstract：:GATA transcription factors have been shown to play important roles in hematopoiesis. GATA-2 is expressed in stem and progenitor cells, and has been speculated to control the proliferation and maintain the immaturity of these cells. To examine whether the function of GATA-2 is changeable according to the differentiatio...

journal_title：International journal of hematology

authors： Harigae H,Okitsu Y,Yokoyama H,Fujiwara T,Inomata M,Takahashi S,Minegishi N,Kaku M,Sasaki T

更新日期：2006-07-01 00:00:00

abstract：:Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...

journal_title：International journal of hematology

authors： Miyamoto T,Yoshimoto G,Kamimura T,Muta T,Takashima S,Ito Y,Shiratsuchi M,Choi I,Kato K,Takenaka K,Iwasaki H,Takamatsu Y,Teshima T,Akashi K

更新日期：2013-09-01 00:00:00