Abstract:
:Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underwent allo-SCT between January 1994 and June 2005 and survived >90 days after transplantation, 57 patients developed BO with a 5-year cumulative incidence of 2.8%. The median time interval from transplantation to BO diagnosis was 335 days (range 83-907 days). The 5-year cumulative incidence of BO was 1.62% in bone marrow transplantation (BMT) from related donors, 3.83% in peripheral blood stem cell transplantation (PBSCT) from related donors (R-PBSCT), 2.91% in BMT from unrelated donors and 2.65% in unrelated cord blood transplantation. The incidence of BO after R-PBSCT was significantly higher than that after any other type of allo-SCT (p = 0.02). R-PBSCT (p = 0.019) and preceding chronic graft-versus-host disease (GVHD) (p < 0.001) were BO-associated risk factors. Overall 5-year survival of patients with BO from the time of diagnosis was 45.4%, significantly less than those without (77.5% from day 335, p < 0.001). R-PBSCT recipients with existent chronic GVHD have a high risk of developing BO, and need extensive care and repeated pulmonary function tests.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Nakaseko C,Ozawa S,Sakaida E,Sakai M,Kanda Y,Oshima K,Kurokawa M,Takahashi S,Ooi J,Shimizu T,Yokota A,Yoshiba F,Fujimaki K,Kanamori H,Sakai R,Saitoh T,Sakura T,Maruta A,Sakamaki H,Okamoto Sdoi
10.1007/s12185-011-0809-8subject
Has Abstractpub_date
2011-03-01 00:00:00pages
375-382issue
3eissn
0925-5710issn
1865-3774pii
10.1007/s12185-011-0809-8journal_volume
93pub_type
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pub_type: 临床试验,杂志文章,多中心研究
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