Abstract:
:Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acute leukemia, and one each of neuroblastoma, severe combined immunodeficiency, Wiskott-Aldrich syndrome, myelodysplastic syndrome, and pyruvate kinase deficiency. The success rate of stem cell transplantation in Thai children varied according to the underlying diseases of the patients, ranging from 50% in acute leukemia to 100% in aplastic anemia. The outcome of stem cell transplantation in 35 thalassemic children revealed 23 (79.4%) were cured, whereas three (10.3%) remain alive with disease and the other three (10.3%) died. The incidence of graft-versus-host disease was low hen compared with that of Western countries. It is concluded that bone marrow, peripheral blood and cord blood stem cell transplantation will be the treatment of choice and will be widely used in the future to cure many hematologic and malignant disorders in children.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil Sdoi
10.1016/s0925-5710(98)00083-8subject
Has Abstractpub_date
1998-12-01 00:00:00pages
411-9issue
4eissn
0925-5710issn
1865-3774pii
S0925571098000838journal_volume
68pub_type
临床试验,杂志文章abstract::Given the poor prognosis of patients with relapsed/refractory acute myeloid leukemia (AML), better therapy is needed. Fludarabine enhances the efficacy of Ara-C (cytarabine) by increasing intracellular Ara-C-triphosphate. The FLAG (fludarabine, high-dose Ara-C, supported with granulocyte colony-stimulating factor) reg...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.04114
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2290-5
更新日期:2017-11-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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更新日期:2017-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1278-z
更新日期:2013-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05154
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981978
更新日期:2002-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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更新日期:2016-01-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
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更新日期:1994-07-01 00:00:00
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journal_title:International journal of hematology
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更新日期:2011-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
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