Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.


:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve the aorta. It is important to consider gemcitabine-induced vasculitis in non-specifically unwell patients with raised inflammatory markers and fever of unknown origin, with or without signs of vascular compromise. Early recognition, cessation of gemcitabine therapy, and high-dose steroids are critical for a good outcome. PET CT is valuable to diagnose large vessel vasculitis and monitor treatment response.


Int J Hematol


Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP




Has Abstract


2014-06-01 00:00:00












  • Successful treatment of refractory cold hemagglutinemia in MYD88 L265P mutation-negative Waldenström's macroglobulinemia with bortezomib.

    abstract::We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

    更新日期:2015-08-01 00:00:00

  • Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells.

    abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén O

    更新日期:2020-04-01 00:00:00

  • In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

    abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

    更新日期:1991-12-01 00:00:00

  • Prognostic value of Waldeyer's ring involvement of diffuse large B-cell lymphoma treated with R-CHOP.

    abstract::The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluo...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Oh MY,Chung JS,Song MK,Shin HJ,Lee HS,Lee SM,Lee GW,Lee SE

    更新日期:2013-03-01 00:00:00

  • Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key.

    abstract::Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing con...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Fu H,Xu L,Liu D,Zhang X,Liu K,Chen H,Wang Y,Han W,Han T,Huang X

    更新日期:2013-07-01 00:00:00

  • Aplastic anemia with circulating erythroblasts.

    abstract::Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yokose N,Ogata K,Dan K,Nomura T

    更新日期:1994-08-01 00:00:00

  • Correction to: Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan.

    abstract::In the original publication of this article, Tables 2, 3 and 4 were published incorrectly. The corrected tables 2, 3 and 4 are given in the following pages. ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,已发布勘误


    authors: Ueda Y,Obara N,Yonemura Y,Noji H,Masuko M,Seki Y,Wada K,Matsuda T,Akiyama H,Ikezoe T,Chiba S,Kanda Y,Kawaguchi T,Shichishima T,Nakakuma H,Okamoto S,Nishimura JI,Kanakura Y,Ninomiya H

    更新日期:2018-08-01 00:00:00

  • A prospective randomized trial of KRN8602 and cytosine arabinoside vs. daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. The KRN8602 Leukemia Study Group.

    abstract::A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

    更新日期:1999-07-01 00:00:00

  • Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent.

    abstract::Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

    更新日期:2005-12-01 00:00:00

  • Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome.

    abstract::We report a case of successful umbilical cord blood transplantation (CBT) for Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) in a 6-year-old girl. The patient had hemophagocytic syndrome with excessive circulating levels of EBV DNA that was refractory to immunochemotherapy. Multiple hepatospleni...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Toubo T,Suga N,Ohga S,Nomura A,Onoe Y,Takada H,Hara T

    更新日期:2004-12-01 00:00:00

  • Increase in plasma thrombin-activatable fibrinolysis inhibitor may not contribute to thrombotic tendency in antiphospholipid syndrome because of inhibitory potential of antiphospholipid antibodies toward TAFI activation.

    abstract::The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Ieko M,Yoshida M,Naito S,Nakabayashi T,Kanazawa K,Mizukami K,Mukai M,Atsumi T,Koike T

    更新日期:2010-06-01 00:00:00

  • Blastic plasmacytoid dendritic cell neoplasm arising from clonal hematopoiesis.

    abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cel...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Suma S,Sakata-Yanagimoto M,Nguyen TB,Hattori K,Sato T,Noguchi M,Nannya Y,Ogawa S,Watanabe R,Fujimoto M,Nakamura N,Kusakabe M,Nishikii H,Kato T,Chiba S

    更新日期:2018-10-01 00:00:00

  • Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children.

    abstract::The distinction between RAEB, RAEB-T and AML M6a is difficult when erythroblasts in the bone marrow (BM) exceed 50%. We analyzed 19 children (2 RAEB, 13 RAEB-T and 4 AML M6a) enrolled in a prospective pathological central review in Japan and divided them into two groups according to the myeloblasts percentage among no...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Honda Y,Manabe A,Tsuchida M,Zaike Y,Masunaga A,Inoue M,Kobayashi R,Ohtsuka Y,Kikuchi A,Nakahata T,From the MDS Committee, the Japanese Society of Pediatric Hematology.

    更新日期:2008-12-01 00:00:00

  • Expression of activated molecules on CD5(+)B lymphocytes in autoimmune hemolytic anemia.

    abstract::To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Zhu H,Xu W,Liu H,Wang H,Fu R,Wu Y,Qu W,Wang G,Guan J,Song J,Xing L,Shao Z

    更新日期:2016-05-01 00:00:00

  • Recent advances in the diagnosis of antiphospholipid syndrome.

    abstract::Antiphospholipid antibodies are autoantibodies directed against anionic phospholipids or protein-phospholipid complexes measured in solid-phase immunoassays such as anticardiolipin (aCL) antibody or detected in phospholipid-dependent clotting tests as lupus anticoagulant (LA). The term "antiphospholipid syndrome (APS)...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Chi HS

    更新日期:2002-08-01 00:00:00

  • Pluripotency maintenance mechanism of embryonic stem cells and reprogramming.

    abstract::Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Masui S

    更新日期:2010-04-01 00:00:00

  • CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region.

    abstract::CD5+ diffuse large B-cell lymphoma (DLBCL) has recently been identified as a subgroup with different clinical characteristics from CD5- DLBCL and as having a poorer outcome than CD5- DLBCL. Data regarding differences in gene alteration between CD5+ and CD5- DLBCL have accumulated. In this article, we report an analysi...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Nakamura N,Nakamura S,Yamaguchi M,Ichinohasama R,Yoshino T,Kuze T,Sasaki Y,Yoshida S,Abe M

    更新日期:2005-01-01 00:00:00

  • Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.

    abstract::The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Oka Y,Tashiro H,Mizutani-Noguchi M,Koga I,Sugao T,Shirasaki R,Miura T,Akiyama N,Kawasugi K,Fujimori S,Shirafuji N

    更新日期:2010-01-01 00:00:00

  • Primary mediastinal large B-cell lymphoma in Japanese children and adolescents.

    abstract::This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

    更新日期:2017-04-01 00:00:00

  • A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.

    abstract::Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Nomoto H,Takami A,Espinoza JL,Matsuo K,Mizuno S,Onizuka M,Kashiwase K,Morishima Y,Fukuda T,Kodera Y,Doki N,Miyamura K,Mori T,Nakao S,Ohtake S,Morishita E

    更新日期:2015-10-01 00:00:00

  • Primary extramedullary plasmacytoma of the small intestine.

    abstract::We report a case of primary extramedullary plasmacytoma (PEMP), IgA kappa type, with a long clinical history, in a 64-year-old Japanese woman. In this case, PEMP occurred primarily in the jejunum and then recurred in several organs, specifically the spleen and stomach, and in the subcutaneous tissue, over a period of ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Homma K,Ihzumi T,Nemoto K,Ohnishi Y

    更新日期:1992-10-01 00:00:00

  • Benefit of simultaneous rhG-CSF and methylprednisolone 'pulse' therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis.

    abstract::A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kondo H,Date Y

    更新日期:1997-02-01 00:00:00

  • Immunodeficient mouse models of lymphoid tumors.

    abstract::Severe combined immunodeficient (SCID) mice lack functional T- and B-cells and readily accept human xenografts, including hematopoietic malignancies. Accordingly, SCID mice have been used to study the growth and behavior of lymphoid tumors in vivo. The SCID mouse models of disease mimic human diseases and have provide...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Imada K

    更新日期:2003-05-01 00:00:00

  • Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin.

    abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

    更新日期:2011-01-01 00:00:00

  • Two case reports of inherited antithrombin deficiency: a novel frameshift mutation and a large deletion including all seven exons detected using two methods.

    abstract::An inherited antithrombin deficiency is an autosomal dominant thrombotic disorder. We identified two pedigrees of inherited type I antithrombin deficiency and two responsible mutations in each. A novel 21-22delAA appeared to have caused a frameshift with a premature termination at amino acid +63 in one patient and a l...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Sekiya A,Morishita E,Karato M,Maruyama K,Shimogawara I,Omote M,Wakugawa Y,Shinohara M,Hayashi T,Kadohira Y,Asakura H,Nakao S,Ohtake S

    更新日期:2011-02-01 00:00:00

  • The effect of adding rituximab to CHOP-based therapy on clinical outcomes for Japanese patients with diffuse large B-cell lymphoma: a propensity score matching analysis.

    abstract::We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

    更新日期:2009-04-01 00:00:00

  • Current status of Japanese HIV-infected patients with coagulation disorders: coinfection with both HIV and HCV.

    abstract::We herein report on the current status of Japanese HIV-positive patients with coagulation disorders, primarily hemophilia, based on the national survey of 31 May 2006. The total number of registered patients was 1,431 (Hemophilia A 1,086; Hemophilia B 325; von Willebrand disease 8; others 12), and 604 of these patient...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Tatsunami S,Mimaya J,Shirahata A,Zelinka J,Horová I,Hanai J,Nishina Y,Ohira K,Taki M

    更新日期:2008-10-01 00:00:00

  • A variant form of acute promyelocytic leukemia with marked myelofibrosis.

    abstract::We describe a variant form, French-American-British (FAB) M3v, of acute promyelocytic leukemia (APL; FAB M3) with atypical morphocytochemical features, immature antigens (CD34 and HLA-DR) and marked myelofibrosis (MF). Usual APL cells do not express CD34 or HLA-DR antigens. MF may be more frequently observed in patien...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Fukuno K,Tsurumi H,Yoshikawa T,Yamada T,Oyama M,Moriwaki H

    更新日期:2001-10-01 00:00:00

  • Factors predisposing to HTLV-1 infection in residents of the greater Tokyo area.

    abstract::Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent for adult T-cell leukemia. The geographic distribution of HTLV-1 carriers is quite uneven in Japan and the greatest prevalence is in southwestern Japan. Because many people move from endemic areas to the greater Tokyo area, the geographic distributio...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Uchimaru K,Nakamura Y,Tojo A,Watanabe T,Yamaguchi K

    更新日期:2008-12-01 00:00:00

  • Chromosomal abnormalities and oncogenes.

    abstract::The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Mitani K

    更新日期:1996-02-01 00:00:00