International collaboration on childhood leukemia.

abstract：:Imatinib mesylate binds to the inactive conformation of BCR-ABL tyrosine kinase, suppressing the Philadelphia chromosome-positive clone in chronic myelogenous leukemia (CML). Clinical studies of imatinib have yielded impressive results in the treatment of all phases of CML. With the higher rates of complete cytogeneti...

journal_title：International journal of hematology

authors： Borthakur G,Cortes JE

更新日期：2004-06-01 00:00:00

abstract：:We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

journal_title：International journal of hematology

authors： Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

更新日期：2015-12-01 00:00:00

abstract：:Inherited antithrombin deficiency, an established risk factor for venous thromboembolism (VTE), can be classified into type I (quantitative deficiency) or type II (qualitative deficiency). In the present study, we assessed the VTE risk associated with the phenotypes of antithrombin deficiency in patients admitted to o...

journal_title：International journal of hematology

authors： Mitsuguro M,Sakata T,Okamoto A,Kameda S,Kokubo Y,Tsutsumi Y,Sano M,Miyata T

更新日期：2010-10-01 00:00:00

abstract：:Autoimmune cytopenias are rare but serious complications after hematopoietic stem cell transplantation (HSCT). We per-formed splenectomy in 2 patients who had severe autoimmune cytopenias after allogeneic HSCT (allo-HSCT) that were resist-ant to immunosuppressive treatment. The first patient underwent unrelated allo-H...

journal_title：International journal of hematology

authors： Proleznik I,Prentice HG,Pretnar J,Zver S,Cernelc P

更新日期：2005-07-01 00:00:00

abstract：:CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding o...

journal_title：International journal of hematology

authors： Shiku H

更新日期：2003-06-01 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...

journal_title：International journal of hematology

authors： Knudsen E,Carlsen H,Bøyum A,Benestad HB,Iversen PO

更新日期：2014-08-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...

journal_title：International journal of hematology

authors： Yanada M,Naoe T

更新日期：2012-08-01 00:00:00

abstract：:A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...

journal_title：International journal of hematology

authors： Suzuki R,Warita T,Nakamura Y,Kitamura Y,Aoyama Y,Ogawa Y,Kawada H,Ando K

更新日期：2019-06-01 00:00:00

abstract：:We evaluated the engraftment and the cell cycle status of marrow cells at various times after 5-fluorouracil (5-FU) administration. 5-FU (150 mg/kg) was given to donor male BALB/c mice at 1, 2, 6, or 12 days prior to marrow harvest. The donor cells were then assessed in host nonmyeloablated female mice. Bone marrow en...

journal_title：International journal of hematology

authors： D'Hondt L,Carlson J,Benoit B,Reilly J,Grimaldi C,Wuu J,Lambert JF,Dooner MS,Quesenberry PJ

更新日期：2001-07-01 00:00:00

abstract：:The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...

journal_title：International journal of hematology

authors： Kakishita E

更新日期：2000-06-01 00:00:00

abstract：:Fas stimulation has been reported to promote the activation and proliferation of T lymphocytes, but the intracellular signalling pathways that mediate non-apoptotic responses to Fas are poorly defined. To distinguish between the activation signalling and the death-inducing pathway downstream of Fas, we generated a nov...

journal_title：International journal of hematology

authors： Shin MJ,Shim JH,Lee JY,Chae WJ,Lee HK,Morio T,Park JH,Chang EJ,Lee SK

更新日期：2010-09-01 00:00:00

abstract：:Hemoglobin (Hb) E is the commonest beta-globin variant in Thailand. Other uncommon variants have been rarely reported. We performed direct DNA sequencing of the entire beta-globin gene in cases showing unidentified bands by isolectric focusing electrophoresis or high-performance liquid chromatography. Six different be...

journal_title：International journal of hematology

authors： Uaprasert N,Rojnuckarin P,Settapiboon R,Amornsiriwat S,Sutcharitchan P

更新日期：2009-06-01 00:00:00

abstract：:Chromosomal translocations are one of the hallmarks of human leukemias. These structural abnormalities result in the generation of genetic mutations that play a direct role in the transformation of hematopoietic stem cells. Some of the most common targets of these chromosomal rearrangements are the genes that encode t...

journal_title：International journal of hematology

authors： Lorsbach RB,Downing JR

更新日期：2001-10-01 00:00:00

abstract：:We investigated the effect of cell surface glycosaminoglycans (GAGs) on the inactivation of factor VIIa-tissue factor activity by antithrombin III (ATIII) on a human bladder carcinoma (J82) cell line and an ovarian carcinoma (OC-2008) cell line, two tumor cell lines which constitutively synthesize and express high lev...

journal_title：International journal of hematology

authors： Hamamoto T,Kisiel W

更新日期：1998-07-01 00:00:00

abstract：:We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...

journal_title：International journal of hematology

authors： Takezawa Y,Terasawa F,Matsuda K,Sugano M,Tanaka A,Fujiwara M,Kainuma K,Okumura N

更新日期：2012-07-01 00:00:00

abstract：:The plasma levels of soluble urokinase-type plasminogen activator receptor (uPAR; CD87) measured by enzyme-linked immunosorbent assay were higher in patients with paroxysmal nocturnal hemoglobinuria (PNH) (5.8 +/- 4.7 ng/ml, mean +/- S.D., n = 9) than in normal donors (2.0 +/- 0.8 ng/ml, mean +/- S.D., n = 15). The hi...

journal_title：International journal of hematology

authors： Ninomiya H,Hasegawa Y,Nagasawa T,Abe T

更新日期：1997-04-01 00:00:00

abstract：:Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeti...

journal_title：International journal of hematology

authors： Goyama S,Kurokawa M

更新日期：2010-06-01 00:00:00

abstract：:Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...

journal_title：International journal of hematology

authors： Owatari S,Otsuka M,Takeshita T,Mizukami K,Suzuki S,Uozumi K,Tashiro Y,Arima N,Hanada S

更新日期：2009-03-01 00:00:00

abstract：:Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...

journal_title：International journal of hematology

authors： Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki M

更新日期：2009-04-01 00:00:00

abstract：:Severe fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precurs...

journal_title：International journal of hematology

authors： Hübel K,Chemnitz J,Brochhagen HG,Cornely OA

更新日期：2004-04-01 00:00:00

abstract：:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of th...

journal_title：International journal of hematology

authors： Aïdoudi S,Lebeurier I,Amiral J,Quentin G,Caen JP,Han ZC

更新日期：1997-12-01 00:00:00

abstract：:Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

journal_title：International journal of hematology

authors： Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

更新日期：2010-04-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

journal_title：International journal of hematology

authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

更新日期：2005-12-01 00:00:00

abstract：:We report a patient with acute monocytic leukemia (AMoL; M5) who received a second bone marrow transplantation (BMT) with graft-versus-leukemia (GVL) effect on relapsed leukemia cutis, which had been refractory to intensive chemotherapy and donor lymphocyte transfusions (DLTs). A 21-year-old woman was diagnosed with A...

journal_title：International journal of hematology

authors： Ashida T,Kawanishi K,Ariyama T,Hamasaki H,Maeda Y,Tsubaki K,Kanamaru A

更新日期：2000-06-01 00:00:00

abstract：:Hemoglobin E-beta thalassemia (Hb E/β-thalassemia) is a distinct, yet common, type of β-thalassemia, in which the patient co-inherits a β-thalassemia allele from one parent, and a structural variant, Hb E, from the other parent. This co-inheritance leads to remarkable clinical heterogeneity, varying degrees of chronic...

journal_title：International journal of hematology

authors： Algiraigri AH,Kassam A

更新日期：2017-12-01 00:00:00

abstract：:The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...

journal_title：International journal of hematology

authors： Bennett JM,Kouides PA,Forman SJ

更新日期：2002-08-01 00:00:00

abstract：:Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carci...

journal_title：International journal of hematology

authors： Kaito K,Otsubo H,Takahara S,Hyouki M,Abe M,Abe I,Usui N

更新日期：2007-02-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

journal_title：International journal of hematology

authors： Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

更新日期：2009-04-01 00:00:00

abstract：:Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex®/Kcentra®) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for ur...

journal_title：International journal of hematology

authors： Kushimoto S,Fukuoka T,Kimura A,Toyoda K,Brainsky A,Harman A,Chung T,Yasaka M

更新日期：2017-12-01 00:00:00

abstract：:Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...

journal_title：International journal of hematology

authors： Yoo KH,Lee H,Suh C,CISL.

更新日期：2018-04-01 00:00:00