Abstract:
:Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeting studies in mice reveal that Evi-1 is preferentially expressed in hematopoietic stem cells (HSCs) and plays an essential role in proliferation/maintenance of HSCs. Proteins associated with EVI-1, signaling pathways regulated by EVI-1, and downstream mediators of EVI-1 transcriptional regulation have been described and characterized. In this study, we summarize current knowledge regarding biochemical properties and biological functions of EVI-1, which provides a foundation for the development of novel therapeutic strategies.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Goyama S,Kurokawa Mdoi
10.1007/s12185-010-0618-5subject
Has Abstractpub_date
2010-06-01 00:00:00pages
753-7issue
5eissn
0925-5710issn
1865-3774journal_volume
91pub_type
杂志文章,评审abstract::The correlation between infant leukemia and in utero exposure to topoisomerase II (topo-II) inhibitor has been clarified. We examined the in vitro effect of topo-II inhibitor (etoposide) on cleavage of the MLL gene in cord and peripheral blood mononuclear cells (MNCs). Southern blot analysis showed cleavage of the MLL...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982722
更新日期:2002-07-01 00:00:00
abstract::The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function. In our institution, we...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2077-0
更新日期:2016-12-01 00:00:00
abstract::Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1598-7
更新日期:2014-08-01 00:00:00
abstract::Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1814-0
更新日期:2015-08-01 00:00:00
abstract::Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-012-1137-3
更新日期:2012-08-01 00:00:00
abstract::The aim of this study was to assess the safety and optimal dose of deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation (HCT). The primary endpoint was the maximum tolerated dose of deferasirox that was determined by the intrapatient dose escalation methods. A total of 16 ...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-017-2396-9
更新日期:2018-05-01 00:00:00
abstract::Hematopoiesis is closely linked with angiogenesis, because they interact with each other and have common ancestors: hemangioblasts or hematogenic endothelial cells. The relationship is reasonable, because vascular and hematopoietic systems must develop together in order to establish the body's oxygen-delivery system d...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2124-x
更新日期:2017-01-01 00:00:00
abstract::Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2141-9
更新日期:2017-03-01 00:00:00
abstract::We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1775-3
更新日期:2015-08-01 00:00:00
abstract::In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Immunosuppression (IS) therapy with antilymphocyte globulin (ALG) is currently the treatment of choice for patients with aplastic anemia who do not have histocompatible sibling donors or who are not candidates for allogeneic bone marrow transplantation. Thirty-eight patients with aplastic anemia who received ALG-based...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.a10306
更新日期:2004-02-01 00:00:00
abstract::Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02798-5
更新日期:2020-03-01 00:00:00
abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1323-y
更新日期:2013-06-01 00:00:00
abstract::Okadaic acid, a newly recognized protein phosphatase inhibitor and a non-TPA type tumor promoter, enhanced 1 alpha 25(OH)2D3(D3)-induced HL-60 cell differentiation into monocyte/macrophage lineage but did not affect dibutyryl cyclic AMP (dbcAMP)-induced differentiation into granulocytic lineage. Okadaic acid alone did...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patie...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02804-w
更新日期:2020-04-01 00:00:00
abstract::Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2147-3
更新日期:2017-04-01 00:00:00
abstract::Bortezomib is a proteasome inhibitor demonstrating substantial activity in multiple myeloma. One of its key toxicities is peripheral neuropathy, which is reversible in most patients. The possibility that bortezomib might in rare cases induce severe neuropathies by auto-inflammatory mechanisms remains controversial. We...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0847-2
更新日期:2011-06-01 00:00:00
abstract::To elucidate the relationship between treatment with granulocyte colony-stimulating factor (G-CSF) and the development of chromosomal abnormalities and clonal evolution in adult aplastic anemia (AA) patients, we performed a prospective multicenter study. Of the 104 registered patients, 91 were found by the central rev...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:2003-02-01 00:00:00
abstract::Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1372-2
更新日期:2013-08-01 00:00:00
abstract::Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2039-6
更新日期:2016-07-01 00:00:00
abstract::The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1016/0925-5710(96)00440-9
更新日期:1996-02-01 00:00:00
abstract::Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-018-2403-9
更新日期:2018-04-01 00:00:00
abstract::Immunological abnormalities (IA) are frequently observed in patients with myelodysplastic syndromes (MDS). Although there have been a number of analyses of the prognostic factors, there have been few studies, if any, to determine whether IA affects prognosis. We investigated the prognosis of 153 MDS patients with or w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(97)00042-x
更新日期:1997-10-01 00:00:00
abstract::The presence of mutations in PRF1, UNC13D, STX11 and STXBP2 genes in homozygosis or compound heterozygosis results in immune deregulation. Most such cases lead to clinical manifestations of haemophagocytic lymphohistiocytosis (HLH). In the present study, we analyzed degranulation and cytotoxicity in a pediatric patien...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02796-7
更新日期:2020-03-01 00:00:00
abstract::We retrospectively investigated increases in large granular lymphocytes (LGL) in peripheral blood during dasatinib treatment in 25 chronic myelogenous leukemia patients. Fifteen of 25 patients (60 %) showed an increase in LGL. All 15 of these patients also showed an increase in NK cells, and 11 showed an increase in C...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1132-8
更新日期:2012-09-01 00:00:00
abstract::Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-014-1641-8
更新日期:2014-10-01 00:00:00
abstract::We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::We herein report on the current status of Japanese HIV-positive patients with coagulation disorders, primarily hemophilia, based on the national survey of 31 May 2006. The total number of registered patients was 1,431 (Hemophilia A 1,086; Hemophilia B 325; von Willebrand disease 8; others 12), and 604 of these patient...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0144-x
更新日期:2008-10-01 00:00:00