Evi-1 as a critical regulator of leukemic cells.

Abstract:

:Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeting studies in mice reveal that Evi-1 is preferentially expressed in hematopoietic stem cells (HSCs) and plays an essential role in proliferation/maintenance of HSCs. Proteins associated with EVI-1, signaling pathways regulated by EVI-1, and downstream mediators of EVI-1 transcriptional regulation have been described and characterized. In this study, we summarize current knowledge regarding biochemical properties and biological functions of EVI-1, which provides a foundation for the development of novel therapeutic strategies.

journal_name

Int J Hematol

authors

Goyama S,Kurokawa M

doi

10.1007/s12185-010-0618-5

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

753-7

issue

5

eissn

0925-5710

issn

1865-3774

journal_volume

91

pub_type

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