Abstract:
:We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-FU) treated mice. We show in this study that a slight modification of the C-terminal peptide related to PF4 (C13-24DE), which was previously reported as the carboxy terminal region of PF4 implicated in PF4 inhibitory activity, is also able to significantly increase murine high proliferating-potential-colony forming cells (HPP-CFC), colony-forming-unit megakaryocyte (CFU-MK) and colony-forming unit granulocyte-macrophage (CFU-GM) progenitor number, eight days after 5-FU administration, when it was given intraperitoneally twice a day (200 micrograms/kg/inj) prior to 5-FU administration (150 mg/kg). Furthermore, the C13-24DE pretreatment enhanced both the number and the diameter of single megakaryocyte (MK) by day 8. These data indicate that the C13-24DE peptide related to PF4 accelerated the in vivo recovery of stem cells, progenitors (CFU-GM, CFU-MK) and single MK after 5-FU treatment and may have a hemoprotective effect against chemotherapeutic agents.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Aïdoudi S,Lebeurier I,Amiral J,Quentin G,Caen JP,Han ZCdoi
10.1016/s0925-5710(97)00065-0subject
Has Abstractpub_date
1997-12-01 00:00:00pages
435-44issue
4eissn
0925-5710issn
1865-3774pii
S0925571097000650journal_volume
66pub_type
杂志文章abstract::Bortezomib is a proteasome inhibitor that can be effective in the treatment of refractory and relapsed multiple myeloma. Recently, severe pulmonary complications associated with bortezomib therapy have been reported in Japan. Because bortezomib has not yet been approved for general use in Japan and is imported by atte...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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abstract::The author would like to correct the error in the "Abstract" section of original publication as given below. ...
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journal_title:International journal of hematology
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