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Signal transduction in macrophages: negative regulation for macrophage colony-stimulating factor receptor signaling.

Abstract：

:The receptor for macrophage colony-stimulating factor (M-CSF) is expressed in monocytes/macrophages and their progenitor cells and stimulates both the growth and development of the blood-cell lineage. Although the specific components positively regulating M-CSF receptor signaling have been relatively well defined, it is now clear that important mechanisms to control the signaling cascades also exist. This review discusses the most recent results concerning the negative regulatory molecules for M-CSF receptor signaling. In particular, we focus on negative molecules for both proliferation of monocytes/macrophages and differentiation into mature cells.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Suzu S,Motoyoshi K

doi

10.1007/BF02982712

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

1-5

issue

1

eissn

0925-5710

issn

1865-3774

journal_volume

76

pub_type

杂志文章,评审

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