Abstract:
:Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone and pegaspargase) in the treatment of advanced and relapsed/refractory ENK/TCL patients. Thirteen patients received a total of 55 cycles of MEDA, with a median of four cycles. At the completion of treatment, the overall response rate was 76.9 %, with a complete response rate of 61.5 %. The 1-year overall survival rate was 69.2 %, and 1-year progression-free survival was 61.5 %. Treatment-related toxicity was monitored in all patients. Grade 3/4 neutropenia occurred in 46.2 % of patients. Serious infections happened in two cases (15.4 %). Grade 3/4 thrombocytopenia occurred in 30.8 % of patients, and 23.1 % received platelet transfusion. Grade 3/4 anemia was observed in 23.1 % of patients. Hepatotoxicity and low fibrinogen were common, but mild. These results show that MEDA regimen is very effective with tolerable adverse effects in the treatment of advanced and relapsed/refractory ENK/TCL. Further prospective trials are expected to validate the efficacy of MEDA in an expanded number of patients.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Ding H,Chang J,Liu LG,Hu D,Zhang WH,Yan Y,Ma LY,Li ZC,Ma YJ,Hao SG,Tao Rdoi
10.1007/s12185-015-1809-xsubject
Has Abstractpub_date
2015-08-01 00:00:00pages
181-7issue
2eissn
0925-5710issn
1865-3774journal_volume
102pub_type
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF03165270
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0275-8
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.05144
更新日期:2005-12-01 00:00:00