IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.

abstract：:Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive sp...

journal_title：International journal of hematology

authors： Krishnan SK,Hill A,Hillmen P,Arnold LM,Brooksbank GL,Wood A,Scarsbrook A,Davies MH,Kelly RJ

更新日期：2013-12-01 00:00:00

abstract：:Patients with mild/moderate hemophilia (H)A, acquired HA (AHA) and lupus anticoagulants (LA), have prolonged aPTTs with low levels of factor (F)VIII activity, but the differentiation of these disorders is complex and time consuming. We established an approach to quickly differentiate these disorders using comprehensiv...

journal_title：International journal of hematology

authors： Matsumoto T,Nogami K,Shima M

更新日期：2017-02-01 00:00:00

abstract：:To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...

journal_title：International journal of hematology

authors： Zhu H,Xu W,Liu H,Wang H,Fu R,Wu Y,Qu W,Wang G,Guan J,Song J,Xing L,Shao Z

更新日期：2016-05-01 00:00:00

abstract：:The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...

journal_title：International journal of hematology

authors： Kuan JW,Su AT,Tay SP,Fong IL,Kubota S,Su'ut L,Osato M,Sashida G

更新日期：2020-02-01 00:00:00

abstract：:Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...

journal_title：International journal of hematology

authors： Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil S

更新日期：1998-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection is usually implicated in thrombocytopenia occurring in newborns and immunocompromised patients. However, the underlying mechanisms remain elusive. This study was conducted to investigate the effects of HCMV infection on the viability of megakaryocytic CHRF-288-11 cells and the un...

journal_title：International journal of hematology

authors： Dou J,Li X,Cai Y,Chen H,Zhu S,Wang Q,Zou X,Mei Y,Yang Q,Li W,Han Y

更新日期：2010-05-01 00:00:00

abstract：:A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

journal_title：International journal of hematology

authors： Kondo H,Date Y

更新日期：1997-02-01 00:00:00

abstract：:A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This...

journal_title：International journal of hematology

authors： Denčić-Fekete M,Đorđević V,Storlazzi CT,Janković G,Bogdanović A,Jovanović J,Rocchi M,Todorić-Živanović B,Strnad M,Gotić M

更新日期：2009-05-01 00:00:00

abstract：:Between 1978-1988, seven cases of multiple myeloma were found in T Town (population 9,000), which is located at the mouth of a large river within the boundaries of Tokushima City, Japan. This is a significantly high incidence, 7.06 per 100,000 as compared with an incidence of 1.20 in Tokushima City itself and 1.53 in ...

journal_title：International journal of hematology

authors： Kosaka M,Okagawa K,Miyamoto Y,Goto T,Saito S

更新日期：1991-10-01 00:00:00

abstract：:Diffuse follicular lymphoma (FL) variant is a rare condition that shows distinctive clinical, morphological, immunophenotypic, and molecular features that distinguish it from classical FL. Diffuse FL variant is characterized by a predominantly diffuse growth pattern, absence of the t (14;18) IGH/BCL2 translocation, CD...

journal_title：International journal of hematology

authors： Martín-Moro F,Marquet-Palomanes J,Piris-Villaespesa M,Lopez-Jiménez J,García-Cosío M

更新日期：2020-08-01 00:00:00

abstract：:Home care has become a treatment option for cancer patients; however, medical practice at patients' homes has been expected mainly for terminal care in Japan. Most physicians believe that it is difficult to treat patients with hematologic malignancy at home because they frequently develop complications requiring urgen...

journal_title：International journal of hematology

authors： Kodama Y,Kami M,Yuji K,Kuboya M,Komatsu T

更新日期：2007-12-01 00:00:00

abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

journal_title：International journal of hematology

authors： Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:The occurrence of adenopathy in patients with myelodysplastic syndrome-associated extramedullary myeloid cell tumors has rarely been reported. We describe a 7-year-old girl with juvenile myelomonocytic leukemia who showed the novel chromosomal abnormality t(9;12)(p22;q24.1) and who developed severe adenopathy of the c...

journal_title：International journal of hematology

authors： Imamura T,Matsuo S,Yoshihara T,Chiyonobu T,Mori K,Ishida H,Nishimura Y,Kasubuchi Y,Naya M,Morimoto A,Hibi S,Imashuku S

更新日期：2004-08-01 00:00:00

abstract：:Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

journal_title：International journal of hematology

authors： Nimer SD,Leung DH,Wolin MJ,Golde DW

更新日期：1994-10-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...

journal_title：International journal of hematology

authors： Nishio N,Kojima S

更新日期：2010-10-01 00:00:00

abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

journal_title：International journal of hematology

authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

更新日期：1999-07-01 00:00:00

abstract：:A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...

journal_title：International journal of hematology

authors： Mizuno S,Kitayama C,Yamaguchi K,Sanada S,Sato T

更新日期：2020-12-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...

journal_title：International journal of hematology

authors： Ruscetti FW,Bartelmez SH

更新日期：2001-07-01 00:00:00

abstract：:To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...

journal_title：International journal of hematology

authors： Wu X,Wang S,Lu X,Shen W,Qiao C,Wu Y,Lu R,Wang S,Zhang J,Hong M,Zhu Y,Li J,He G

更新日期：2018-08-01 00:00:00

abstract：:The unique feature of paroxysmal nocturnal hemoglobinuria (PNH), a chronic disease with severe hemolytic anemia, is the presence of a population of blood cells that, being deficient in surface proteins tethered to the membrane through a glycosylphosphatidylinositol molecule, are said to have the PNH phenotype. Therefo...

journal_title：International journal of hematology

authors： Luzzatto L,Gianfaldoni G

更新日期：2006-08-01 00:00:00

abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

journal_title：International journal of hematology

authors： Kakinoki Y,Kubota H,Yamamoto Y

更新日期：2004-01-01 00:00:00

abstract：:We describe 3 unrelated Japanese patients with familial Mediterranean fever (FMF) due to a compound heterozygous E148Q/M694I mutation in the MEFV gene. The first patient is a 38-year-old man who also has chronic myelogenous leukemia (CML). Because genomic DNA analysis of the patient's nail revealed the E148Q/M694I mut...

journal_title：International journal of hematology

authors： Kotone-Miyahara Y,Takaori-Kondo A,Fukunaga K,Goto M,Hayashino Y,Miki M,Takayama H,Sasada M,Uchiyama T

更新日期：2004-04-01 00:00:00

abstract：:We report three cases of adult leukemias with the t(1;19)(q23;p13) translocation, two with acute lymphoblastic leukemia (ALL:L2) and one with megakaryoblastic crisis of chronic myelocytic leukemia. Only one patient with ALL showed the same E2A/PBX1 fusion transcripts as those observed in childhood ALLs with the t(1;19...

journal_title：International journal of hematology

authors： Mitani K,Sasaki K,Ogawa S,Hayashi Y,Mano H,Yazaki Y,Hirai H

更新日期：1994-12-01 00:00:00

abstract：:The study was aimed to explore the efficacy and safety of allo-HSCT with high-dose cyclophosphamide-induced immune tolerance for SAA. In the present study, 20 cases (12 male, 8 female; average age = 17.8 years) received reduced-intensity conditioning allo-HSCT from August 2012 to August 2014 in the Beijing Military Re...

journal_title：International journal of hematology

authors： Guo Z,Gao HY,Zhang TY,Liu XD,Yang K,Lou JX,He XP,Zhang Y,Chen P,Chen HR

更新日期：2016-12-01 00:00:00

abstract：:Persistent infection with human parvovirus B19 (B19) is primarily associated with chronic bone marrow failure in immunocompromised patients, but occasionally this organism may also affect immunocompetent hosts. B19 is also suggested as a causative agent of organ failure during bone marrow transplantation (BMT). We her...

journal_title：International journal of hematology

authors： Goto H,Ishida A,Fujii H,Kuroki F,Takahashi H,Ikuta K,Kai S,Yokota S

更新日期：2004-05-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:The current cure rate of childhood acute lymphoblastic leukemia has reached 80% in many industrialized countries, but in developing countries the rate is often less than 10%. To advance the cure rate, investigators have formed several parallel initiatives in both industrialized and developing countries through interna...

journal_title：International journal of hematology

authors： Pui CH,Ribeiro RC

更新日期：2003-12-01 00:00:00

abstract：:A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...

journal_title：International journal of hematology

authors： Sakamaki H,Ishizawa KI,Taniwaki M,Fujisawa S,Morishima Y,Tobinai K,Okada M,Ando K,Usui N,Miyawaki S,Utsunomiya A,Uoshima N,Nagai T,Naoe T,Motoji T,Jinnai I,Tanimoto M,Miyazaki Y,Ohnishi K,Iida S,Okamoto S,Seriu

更新日期：2009-04-01 00:00:00

abstract：:Mesenchymal stromal cells (MSC) have attracted the attention of scientists and clinicians due to their self-renewal, capacity for multipotent differentiation, and immunomodulatory properties. Some essential problems remain to be solved before the clinical application of MSC. Platelet lysate (PL) has recently been used...

journal_title：International journal of hematology

authors： Hao L,Sun H,Wang J,Wang T,Wang M,Zou Z

更新日期：2012-01-01 00:00:00

abstract：:The correlation between infant leukemia and in utero exposure to topoisomerase II (topo-II) inhibitor has been clarified. We examined the in vitro effect of topo-II inhibitor (etoposide) on cleavage of the MLL gene in cord and peripheral blood mononuclear cells (MNCs). Southern blot analysis showed cleavage of the MLL...

journal_title：International journal of hematology

authors： Ishii E,Eguchi M,Eguchi-Ishimae M,Yoshida N,Oda M,Zaitsu M,Fujita I,Miyazaki S,Hamasaki Y,Mizutani S

更新日期：2002-07-01 00:00:00