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Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.

Abstract：

:The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal individuals using a non-qPCRIS method. In the present study, we examined the prevalence of BCR-ABL1 in a normal population in southern Sarawak by performing qPCRIS for BCR-ABL1 with ABL1 as an internal control on total white blood cells, using an unbiased sampling method. While 146 of 190 (76.8%) or 102 of 190 (53.7%) samples showed sufficient amplification of the ABL1 gene at > 20,000 or > 100,000 copy numbers, respectively, in qPCRIS, one of the 190 samples showed amplification of BCR-ABL1 with positive qPCRIS of 0.0023% and 0.0032% in two independent experiments, the sequence of which was the BCR-ABL1 e13a2 transcript. Thus, we herein demonstrated that the BCR-ABL1 fusion gene is expected to be present in approximately 0.5-1% of normal individuals in southern Sarawak.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Kuan JW,Su AT,Tay SP,Fong IL,Kubota S,Su'ut L,Osato M,Sashida G

doi

10.1007/s12185-019-02768-x

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

217-224

issue

2

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-019-02768-x

journal_volume

111

pub_type

杂志文章

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