Abstract:
:Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which reduced the size of the spleen and improved his blood count to the point that blood transfusions were no longer necessary. Splenic embolization was chosen over splenectomy due to the potential postoperative complications of splenectomy, especially that of thrombosis.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Krishnan SK,Hill A,Hillmen P,Arnold LM,Brooksbank GL,Wood A,Scarsbrook A,Davies MH,Kelly RJdoi
10.1007/s12185-013-1454-1subject
Has Abstractpub_date
2013-12-01 00:00:00pages
716-8issue
6eissn
0925-5710issn
1865-3774journal_volume
98pub_type
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章,评审
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abstract::The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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