Differential expression of HOX genes upon activation of leukocyte sub-populations.

abstract：:Allogeneic hematopoietic stem-cell transplantation (HSCT) for chronic granulomatous disease (CGD) with a reduced-intensity conditioning regimen can be expected to lead to less therapy-related mortality and late-onset impairment, whereas it has also been reported to increase the risk of unsustained mixed donor chimeris...

journal_title：International journal of hematology

authors： Hasegawa D,Fukushima M,Hosokawa Y,Takeda H,Kawasaki K,Mizukami T,Nunoi H,Ochiai H,Morio T,Kosaka Y

更新日期：2008-01-01 00:00:00

abstract：:The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...

journal_title：International journal of hematology

authors： Mitani K

更新日期：1996-02-01 00:00:00

abstract：:Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...

journal_title：International journal of hematology

authors： Suvatte V,Tanphaichitr VS,Visuthisakchai S,Mahasandana C,Veerakul G,Chongkolwatana V,Chandanayingyong D,Issaragrisil S

更新日期：1998-12-01 00:00:00

abstract：:Abnormal platelet-derived growth factor receptor (PDGFR)-mediated signaling may cause hematologic neoplasm. The PDGFR beta (PDGFRB) gene, located at chromosome band 5q31-33, forms a fusion gene as a result of chromosome translocation. Although patients with PDGFRB rearrangement mostly present with myeloproliferative n...

journal_title：International journal of hematology

authors： Shimomura Y,Maruoka H,Ishikawa T

更新日期：2017-05-01 00:00:00

abstract：:Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...

journal_title：International journal of hematology

authors： Harada-Shirado K,Wang X,Mori H,Fukatsu M,Takahashi H,Shichishima-Nakamura A,Kimura S,Ohkawara H,Yamada S,Ito T,Ikezoe T

更新日期：2020-03-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:Severe fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precurs...

journal_title：International journal of hematology

authors： Hübel K,Chemnitz J,Brochhagen HG,Cornely OA

更新日期：2004-04-01 00:00:00

abstract：:The presence of mutations in PRF1, UNC13D, STX11 and STXBP2 genes in homozygosis or compound heterozygosis results in immune deregulation. Most such cases lead to clinical manifestations of haemophagocytic lymphohistiocytosis (HLH). In the present study, we analyzed degranulation and cytotoxicity in a pediatric patien...

journal_title：International journal of hematology

authors： Viñas-Giménez L,Donadeu L,Alsina L,Rincón R,de la Campa EÁ,Esteve-Sole A,Català A,Colobran R,de la Cruz X,Sayós J,Martínez-Gallo M

更新日期：2020-03-01 00:00:00

abstract：:To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...

journal_title：International journal of hematology

authors： Wu X,Wang S,Lu X,Shen W,Qiao C,Wu Y,Lu R,Wang S,Zhang J,Hong M,Zhu Y,Li J,He G

更新日期：2018-08-01 00:00:00

abstract：:Hematologic malignancies have historically been characterized by morphologic, immunophenotypic, molecular, and genetic features. However, morphologically identical tumors can have clearly distinct clinical outcomes, suggesting underlying biological heterogeneity. Recent advances in microarray technology have helped th...

journal_title：International journal of hematology

authors： Savage KJ,Gascoyne RD

更新日期：2004-12-01 00:00:00

abstract：:We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...

journal_title：International journal of hematology

authors： Houwing ME,Koopman-Coenen EA,Kersseboom R,Gooskens S,Appel IM,Arentsen-Peters ST,de Vries AC,Reinhardt D,Stary J,Baruchel A,de Haas V,Blink M,Lopes Cardozo RH,Pieters R,Michel Zwaan C,van den Heuvel-Eibrink MM

更新日期：2015-07-01 00:00:00

abstract：:Shwachman-Diamond syndrome (SDS) is a rare congenital disorder featuring exocrine pancreatic insufficiency, growth retardation, and bone marrow dysfunction. Reports suggest that nearly 25% of all cases are complicated with leukemia. Although stem cell transplantation is the sole option for these patients, successful r...

journal_title：International journal of hematology

authors： Mitsui T,Kawakami T,Sendo D,Katsuura M,Shimizu Y,Hayasaka K

更新日期：2004-02-01 00:00:00

abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

journal_title：International journal of hematology

authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

更新日期：1999-07-01 00:00:00

abstract：:The changes of the FVIII binding capacity of vWF after the infusion of FVIII/vWF concentrate was studied in two patients with type 2N vWD, and also during pregnancy in one of them. After infusion of FVIII or DDAVP to the patients, FVIII:C in plasma increased as expected, but it then decreased, with a markedly short ha...

journal_title：International journal of hematology

authors： Nishino M,Nishino S,Sugimoto M,Shibata M,Tsuji S,Yoshioka A

更新日期：1996-08-01 00:00:00

abstract：:A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

journal_title：International journal of hematology

authors： Kuyama J,Fushino M,Take H,Kanayama Y

更新日期：1995-12-01 00:00:00

abstract：:We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m2) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and c...

journal_title：International journal of hematology

authors： Fujii N,Maeda Y,Takenaka K,Shinagawa K,Imai T,Kozuka T,Ikeda K,Sunami K,Hiramatsu Y,Ishimaru F,Niiya K,Harada M

更新日期：2000-12-01 00:00:00

abstract：:In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

journal_title：International journal of hematology

authors： Sheu JR,Hsiao G,Lee YM,Yen MH

更新日期：2001-04-01 00:00:00

abstract：:Bone marrow transplantation is widely accepted as the first line therapy for patients with severe aplastic anemia. Patients with less severe forms of aplastic anemia are treated with immunosuppressive agents, hematopoietic growth factors or androgenic steroids. The use of rabbit anti-human thymocyte globulin allowed u...

journal_title：International journal of hematology

authors： Yoshida Y,Ichinoe T,Dodo M,Noukawa M,Maeda A,Oguma S,Tajima M,Yamamoto K,Okuma M

更新日期：1994-07-01 00:00:00

abstract：:To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

journal_title：International journal of hematology

authors： Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

更新日期：1992-06-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) is abundant in biological organisms. PolyP is a major component of dense granules of human platelets and is secreted upon platelet activation. Studies from our lab and others have shown that polyP is a potent modulator of the blood clotting cascade, acting as a pro-hemostatic, prothromb...

journal_title：International journal of hematology

authors： Morrissey JH

更新日期：2012-04-01 00:00:00

abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

journal_title：International journal of hematology

authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

更新日期：2014-02-01 00:00:00

abstract：:Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...

journal_title：International journal of hematology

authors： Braggio E,Maiolino A,Gouveia ME,Magalhães R,Souto Filho JT,Garnica M,Nucci M,Renault IZ

更新日期：2010-01-01 00:00:00

abstract：:Bleeding is reportedly one of the major causes of death in patients with chronic neutrophilic leukemia (CNL), but thrombocytopenia, abnormal platelet functions, or coagulopathy has been confirmed to be the cause of the bleeding tendency in only a small proportion of the patients. We report the case of a 49-year-old wo...

journal_title：International journal of hematology

authors： Noguchi T,Ikeda K,Yamamoto K,Ashiba A,Yoshida J,Munemasa M,Takenaka K,Shinagawa K,Ishimaru F,Yoshino T,Niiya K,Harada M

更新日期：2001-12-01 00:00:00

abstract：:The addition of rituximab to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) improved the outcome of patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab (R-CHOP) is still not determined in primary mediastinal large B-cell lymphoma (PMBCL), a subtype of DLBCL, especial...

journal_title：International journal of hematology

authors： Ahn HK,Kim SJ,Yun J,Yi JH,Kim JH,Won YW,Kim K,Ko YH,Kim WS

更新日期：2010-04-01 00:00:00

abstract：:The survival, proliferation, and differentiation of hematopoietic cells are regulated by cytokines. In the absence of cytokines, hematopoietic cells not only stop proliferation, but undergo apoptosis. This strict dependency of hematopoietic cells on cytokines is an important mechanism that maintains the homeostasis of...

journal_title：International journal of hematology

authors： Miyajima A,Ito Y,Kinoshita T

更新日期：1999-04-01 00:00:00

abstract：:Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...

journal_title：International journal of hematology

authors： Piccin A,Tagnin M,Vecchiato C,Al-Khaffaf A,Beqiri L,Kaiser C,Agreiter I,Negri G,Kob M,Di Pierro A,Vittadello F,Mazzoleni G,Eisendle K,Fontanella F

更新日期：2018-12-01 00:00:00

abstract：:The clinicopathological and biological significance of Hodgkin's disease and non-Hodgkin's lymphoma, which are infrequently encountered in women of childbearing age, remains to be clarified. We recently reviewed 4 cases of non-Hodgkin's lymphoma of the T/natural killer (T/NK)-cell phenotype, all of which were associat...

journal_title：International journal of hematology

authors： Kato M,Ichimura K,Hayami Y,Iida S,Wakita A,Ueda R,Nakamura S

更新日期：2001-08-01 00:00:00

abstract：:Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...

journal_title：International journal of hematology

authors： Aoki Y,Matsubara Y

更新日期：2013-01-01 00:00:00

abstract：:The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disease characteristics ...

journal_title：International journal of hematology

authors： Webb MJ,Barrett CL,Pretorius C,van Jaarsveld MF,Louw VJ

更新日期：2012-05-01 00:00:00

abstract：:The correct name of the corresponding author should be ''Maryam Mehrpooya'', and not ''Mehrpooya Maryam'' as given in the original publication of the article. ...

journal_title：International journal of hematology

authors： Tavakoli-Ardakani M,Kheshti R,Mehrpooya M

更新日期：2018-01-01 00:00:00