Changes in factor VIII binding capacity of von Willebrand factor and factor VIII coagulant activity in two patients with type 2N von Willebrand disease after hemostatic treatment and during pregnancy.

abstract：:The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...

journal_title：International journal of hematology

authors： Bennett JM,Kouides PA,Forman SJ

更新日期：2002-08-01 00:00:00

abstract：:The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

journal_title：International journal of hematology

authors： Morgan R,Whiting K

更新日期：2008-04-01 00:00:00

abstract：:Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carci...

journal_title：International journal of hematology

authors： Kaito K,Otsubo H,Takahara S,Hyouki M,Abe M,Abe I,Usui N

更新日期：2007-02-01 00:00:00

abstract：:There is an ongoing search for potential biomarkers for acute myeloid leukemia (AML) patients using metabolic analysis. However, only few studies to date have focused on bone marrow samples or a specific subtype of AML. In the present study, we used gas chromatography time-of-flight mass spectrometry of plasma and bon...

journal_title：International journal of hematology

authors： Zhou X,Zheng M,Wang Q,Aa J,Cao B,Li J

更新日期：2020-06-01 00:00:00

abstract：:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

journal_title：International journal of hematology

authors： Takaori-Kondo A

更新日期：2006-04-01 00:00:00

abstract：:Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six p...

journal_title：International journal of hematology

authors： Yoo C,Yoon DH,Kim JE,Jo J,Park SJ,Yoon SK,Ahn Y,Kim S,Huh J,Lee DH,Suh C

更新日期：2013-02-01 00:00:00

abstract：:We present a patient with refractory multiple myeloma who showed a good response to a combination therapy with oral melphalan, dexamethasone, and thalidomide (MDT). A 48-year-old woman with myeloma refractory to thalidomide, dexamethasone, and clarithromycin received 6 mg melphalan for 4 days every 6 weeks in combinat...

journal_title：International journal of hematology

authors： Asou N,Izuno Y,Okubo T,Ide K,Ueno H,Kawakita M,Mitsuya H,Hata H

更新日期：2007-07-01 00:00:00

abstract：:According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

journal_title：International journal of hematology

authors： Zoi K,Cross NC

更新日期：2015-03-01 00:00:00

abstract：:A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...

journal_title：International journal of hematology

authors： Sakamaki H,Ishizawa KI,Taniwaki M,Fujisawa S,Morishima Y,Tobinai K,Okada M,Ando K,Usui N,Miyawaki S,Utsunomiya A,Uoshima N,Nagai T,Naoe T,Motoji T,Jinnai I,Tanimoto M,Miyazaki Y,Ohnishi K,Iida S,Okamoto S,Seriu

更新日期：2009-04-01 00:00:00

abstract：:We evaluated the efficacy and safety of switching to nilotinib in CML-CP patients who had achieved MMR with continuous detectable BCR-ABL1 transcript levels after long-term imatinib treatment. Patients who had achieved MMR, but not deep molecular response (DMR), after > 18 months from the initiation of imatinib receiv...

journal_title：International journal of hematology

authors： Ishikawa J,Matsumura I,Kawaguchi T,Kuroda J,Nakamae H,Miyamoto T,Matsuoka KI,Shibayama H,Hino M,Hirase C,Kamimura T,Shimose T,Akashi K,Kanakura Y

更新日期：2018-05-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CL...

journal_title：International journal of hematology

authors： Xu W,Cao X,Miao KR,Qiao C,Wu YJ,Liu Q,Fan L,Li JY

更新日期：2009-09-01 00:00:00

abstract：:Cardiac dysfunction due to transfusional iron overload is one of the most critical complications for patients with transfusion-dependent hematological disorders. Clinical parameters such as total red blood cell (RBC) transfusion units and serum ferritin level are usually considered as indicators for initiation of iron...

journal_title：International journal of hematology

authors： Sakuta J,Ito Y,Kimura Y,Park J,Tokuuye K,Ohyashiki K

更新日期：2010-12-01 00:00:00

abstract：:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

journal_title：International journal of hematology

authors： Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

更新日期：2004-11-01 00:00:00

abstract：:The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...

journal_title：International journal of hematology

authors： Baldoni S,Sportoletti P,Del Papa B,Aureli P,Dorillo E,Rosati E,Ciurnelli R,Marconi P,Falzetti F,Di Ianni M

更新日期：2013-08-01 00:00:00

abstract：:A 32-year-old male patient with severe factor VIII (FVIII) deficiency had developed a high-titer FVIII inhibitor at age 13. Recurrent hemarthroses caused bony destruction in both knees, significantly impairing his ability to walk. Knee examination revealed 20 degrees of varus, destruction of the medial joint line, and...

journal_title：International journal of hematology

authors： Carr ME Jr,Loughran TP,Cardea JA,Smith WK,Kuhn JG,Dottore MV

更新日期：2002-01-01 00:00:00

abstract：:Hematopoietic cells can be exposed to a wide spectrum of oxidative stresses. Excessive oxidative stress damages biomolecules such as DNA, proteins, and lipids, leading to cellular dysfunction and cell death. Accumulation of such damage provokes noxious effects on individuals, resulting in diseases such as hematopoieti...

journal_title：International journal of hematology

authors： Masutani H

更新日期：2000-01-01 00:00:00

abstract：:We examined the effect of H2O2 on the regulation of the human erythropoietin (Epo) gene through the GATA sequence in the Epo promoter in Hep3B cells. The addition of exogenous H2O2 in Hep3B cells inhibited hypoxia-induced Epo production of mRNA as assessed by competitive polymerase chain reaction (PCR) and protein by ...

journal_title：International journal of hematology

authors： Imagawa S,Yamamoto M,Ueda M,Miura Y

更新日期：1996-10-01 00:00:00

abstract：:An inherited antithrombin deficiency is an autosomal dominant thrombotic disorder. We identified two pedigrees of inherited type I antithrombin deficiency and two responsible mutations in each. A novel 21-22delAA appeared to have caused a frameshift with a premature termination at amino acid +63 in one patient and a l...

journal_title：International journal of hematology

authors： Sekiya A,Morishita E,Karato M,Maruyama K,Shimogawara I,Omote M,Wakugawa Y,Shinohara M,Hayashi T,Kadohira Y,Asakura H,Nakao S,Ohtake S

更新日期：2011-02-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

journal_title：International journal of hematology

authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

更新日期：2005-12-01 00:00:00

abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

journal_title：International journal of hematology

authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

更新日期：2013-03-01 00:00:00

abstract：:The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts ar...

journal_title：International journal of hematology

authors： Tominaga-Sato S,Tsushima H,Ando K,Itonaga H,Imaizumi Y,Imanishi D,Iwanaga M,Taguchi J,Fukushima T,Yoshida S,Hata T,Moriuchi Y,Kuriyama K,Mano H,Tomonaga M,Miyazaki Y

更新日期：2011-07-01 00:00:00

abstract：:To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

journal_title：International journal of hematology

authors： Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

更新日期：1992-06-01 00:00:00

abstract：:The phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase plays a crucial role in host defense by neutrophils and macrophages. When cells ingest invading microbes, this enzyme becomes activated to reduce molecular oxygen to superoxide, a precursor of microbicidal oxidants, in the phagosome. The catalyt...

journal_title：International journal of hematology

authors： Minakami R,Sumimotoa H

更新日期：2006-10-01 00:00:00

abstract：:The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the long-term benefits of this strategy in Japan remain unclear. Therefore, in this study, 109 cancer patients enroll...

journal_title：International journal of hematology

authors： Kohda K,Sakamaki S,Matsunaga T,Kuga T,Fujimi A,Konuma Y,Kusakabe T,Kogawa K,Akiyama T,Koike K,Hirayama Y,Sasagawa Y,Nojiri S,Hirata Y,Nishisato T,Niitsu GY,Hokkaido Society of Peripheral Blood Stem Cell Transplantation.

更新日期：2001-02-01 00:00:00

abstract：:Pediatric patients with acute myeloid leukemia (AML) are at high risk of invasive fungal infection (IFI). In adult patients, the D-index, which reflects the duration and intensity of neutropenia, was reported as a predictive factor of IFI after induction therapy for AML. The aim of this study was to assess whether the...

journal_title：International journal of hematology

authors： Sano H,Kobayashi R,Suzuki D,Hori D,Kishimoto K,Kobayashi K

更新日期：2018-07-01 00:00:00

abstract：:Recent studies have shown that tumors of relapsed acute myeloid leukemia (AML) present additional genetic mutations compared to the primary tumors. The base excision repair (BER) pathway corrects oxidatively damaged mutagenic bases and plays an important role in maintaining genetic stability. The purpose of the presen...

journal_title：International journal of hematology

authors： Gotoh N,Saitoh T,Takahashi N,Kasamatsu T,Minato Y,Lobna A,Oda T,Hoshino T,Sakura T,Shimizu H,Takizawa M,Handa H,Yokohama A,Tsukamoto N,Murakami H

更新日期：2018-09-01 00:00:00

abstract：:Familial platelet disorder (FPD) is a rare autosomal dominant disorder which causes moderate thrombocytopenia with or without impaired platelet function. Patients have a propensity to develop acute myeloid leukemia (AML), and various types of second hits have been postulated in the evolution to AML. However, only a fe...

journal_title：International journal of hematology

authors： Nishimoto N,Imai Y,Ueda K,Nakagawa M,Shinohara A,Ichikawa M,Nannya Y,Kurokawa M

更新日期：2010-07-01 00:00:00

abstract：:Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less exp...

journal_title：International journal of hematology

authors： Cui Q,Sha P,Chen H,Shen H,Qin L,Li Z,Wu T,Wang Z

更新日期：2018-01-01 00:00:00

abstract：:We established a simple method of T cell depletion using anti-CD6 monoclonal antibody-conjugated immunomagnetic beads. Preliminary experiments using this method demonstrated that CD3+ T cells could be partially depleted without depleting CD56+ NK cells. A phase I-II clinical study was performed to assess the safety an...

journal_title：International journal of hematology

authors： Sao H,Kitaori K,Kasai M,Shimokawa T,Kato C,Yamanishi H,Ueda R,Morishima Y

更新日期：1999-01-01 00:00:00

abstract：:We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, t...

journal_title：International journal of hematology

authors： Kitamura K,Nishiyama T,Ishiyama K,Miyawaki S,Miyazaki K,Suzuki K,Masaie H,Okada M,Ogawa H,Imai K,Kiyoi H,Naoe T,Yokoyama Y,Chiba S,Hata T,Miyazaki Y,Hatta Y,Takeuchi J,Nannya Y,Kurokawa M,Ueda Y,Koga D,Sugiyam

更新日期：2016-01-01 00:00:00