Abstract:
:Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carcinoembryonic antigen (CEA) that correlated well with disease status and IgA level. We detected CEA-specific messenger RNA in plasma cells by means of a recently introduced rapid and quantitative RNA-amplification system, the transcription-reverse transcription concerted reaction system. This report is the first of a patient with a diagnosis of CEA-producing multiple myeloma.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kaito K,Otsubo H,Takahara S,Hyouki M,Abe M,Abe I,Usui Ndoi
10.1532/IJH97.06169subject
Has Abstractpub_date
2007-02-01 00:00:00pages
128-31issue
2eissn
0925-5710issn
1865-3774pii
5711568K20671630journal_volume
85pub_type
杂志文章abstract::Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly i...
journal_title:International journal of hematology
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journal_title:International journal of hematology
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abstract::The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow ...
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journal_title:International journal of hematology
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