Abstract:
:Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chelating agent used in the treatment of Wilson's disease. The anaemia improved after dose reduction of trientine. The mechanism of induction of sideroblastic anaemia in this case is unclear, but trientine does not appear to alter the function of two key mitochondrial haem enzymes, and may instead act directly on mitochondrial iron metabolism.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Perry AR,Pagliuca A,Fitzsimons EJ,Mufti GJ,Williams Rdoi
10.1016/0925-5710(96)00457-4subject
Has Abstractpub_date
1996-07-01 00:00:00pages
69-72issue
1eissn
0925-5710issn
1865-3774pii
0925571096004574journal_volume
64pub_type
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