Demographic characteristics, thromboembolism risk, and treatment patterns for patients with cold agglutinin disease in Japan.

Abstract:

:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan. Patients with CAD (at least three claims with a CAD diagnosis; Japanese Disease Code 2830009) and non-CAD controls were retrospectively identified (2008-2017) from a large hospital-based administrative claims dataset in Japan. Cohorts were compared using conditional logistic regression. We identified 344 patients with CAD (53.2% female; mean age: 66.8 years) and 3440 matched controls. Patients with CAD had higher TE rates than controls (34.9% vs. 17.9%; P < 0.0001). Both arterial and venous TEs were increased in the CAD group when compared with the control group (25.0% vs. 4.6% and 8.4% vs. 4.0%, respectively; both P < 0.0001). Most arterial TEs in the CAD cohort (87.2%) were myocardial infarctions. The overall odds ratio for TE development in CAD was 2.81 (95% confidence interval 2.18-3.61). CAD in Japan is characterized by an increased risk of TE. The rate of arterial TEs was particularly high in this patient population.

journal_name

Int J Hematol

authors

Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

doi

10.1007/s12185-020-02899-6

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

307-315

issue

3

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-020-02899-6

journal_volume

112

pub_type

杂志文章
  • Differential expression of HOX genes upon activation of leukocyte sub-populations.

    abstract::The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-008-0057-8

    authors: Morgan R,Whiting K

    更新日期:2008-04-01 00:00:00

  • Long-term culture of leukemic bone marrow primary cells in biomimetic osteoblast niche.

    abstract::We constructed a "biomimetic osteoblast niche" with bio-derived bone as a scaffold, on which we seeded marrow mesenchymal stem cells (MSCs) from CML patients, and induced the MSCs to differentiate into osteoblasts. Bone marrow mononuclear cells from CML patients were cultured in the biomimetic niche (3D culture system...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0392-4

    authors: Hou L,Liu T,Tan J,Meng W,Deng L,Yu H,Zou X,Wang Y

    更新日期:2009-10-01 00:00:00

  • Successful treatment with bortezomib in type-1 cryoglobulinemic vasculitis patient after rituximab failure: a case report and literature review.

    abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-013-1323-y

    authors: Besada E,Vik A,Koldingsnes W,Nossent JC

    更新日期:2013-06-01 00:00:00

  • Response to cyclosporine A and corticosteroids in adult patients with acquired pure red cell aplasia: serial experience at a single center.

    abstract::To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-018-2446-y

    authors: Wu X,Wang S,Lu X,Shen W,Qiao C,Wu Y,Lu R,Wang S,Zhang J,Hong M,Zhu Y,Li J,He G

    更新日期:2018-08-01 00:00:00

  • Low proportion of G0-phase cells during induction chemotherapy correlates with subsequent remission in acute myeloid leukemia.

    abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Kamikubo KH,Ogata K,An E,Dan K

    更新日期:2000-04-01 00:00:00

  • Recent advance in molecular iron metabolism: translational disorders of ferritin.

    abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02982789

    authors: Kato J,Niitsu Y

    更新日期:2002-10-01 00:00:00

  • No V(H) somatic hypermutation was detected in B-cells of a patient with macroglobulinemia due to splenic marginal zone lymphoma.

    abstract::B-cell diseases are classified on the basis of the normal differentiation stages. We report here a case of a patient with a long history of leukocytosis, splenomegaly without lymphadenopathy, and hyperviscosity symptoms. Clinically, the patient's diagnosis was leukemic Waldenstrom macroglobulinemia. Chromosomal analys...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982811

    authors: Sekikawa T,Takahara S,Kawano T,Nakada S,Ito K,Iwase S,Yamada H,Kobayashi M,Horiguchi-Yamada J

    更新日期:2002-12-01 00:00:00

  • Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.

    abstract::According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-014-1670-3

    authors: Zoi K,Cross NC

    更新日期:2015-03-01 00:00:00

  • Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma.

    abstract::We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1873-2

    authors: Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

    更新日期:2015-12-01 00:00:00

  • Tuberculosis-associated hemophagocytic syndrome in a hemodialysis patient with protracted fever.

    abstract::Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow a...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/ijh97.a10315

    authors: Chien CC,Chiou TJ,Lee MY,Hsiao LT,Kwang WK

    更新日期:2004-05-01 00:00:00

  • Allogeneic bone marrow transplantation of chronic myeloid leukemia from an HLA-matched unrelated donor with the beta-thalassemic trait.

    abstract::We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reactio...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Sue YC,Liu TC,Chang CS,Huang SM,Chen TP,Lin SF

    更新日期:1999-04-01 00:00:00

  • Aplastic anemia with circulating erythroblasts.

    abstract::Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Yokose N,Ogata K,Dan K,Nomura T

    更新日期:1994-08-01 00:00:00

  • Stable response after administration of stem cell factor combined with granulocyte colony-stimulating factor in aplastic anemia.

    abstract::We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.05098

    authors: Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

    更新日期:2006-06-01 00:00:00

  • A retrospective clinical analysis of Japanese patients with peripheral T-cell lymphoma not otherwise specified: Hokkaido Hematology Study Group.

    abstract::Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s12185-013-1383-z

    authors: Torimoto Y,Sato K,Ikuta K,Hayashi T,Hirayama Y,Inamura J,Kobayashi H,Kobayashi R,Koda K,Kurosawa M,Mori A,Ota S,Sakai H,Shigematsu A,Shindo M,Shinzaki H,Takahashi F,Takimoto R,Tanaka J,Yamamoto S,Kohgo Y,Fukuhar

    更新日期:2013-08-01 00:00:00

  • NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion.

    abstract::The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s12185-013-1368-y

    authors: Baldoni S,Sportoletti P,Del Papa B,Aureli P,Dorillo E,Rosati E,Ciurnelli R,Marconi P,Falzetti F,Di Ianni M

    更新日期:2013-08-01 00:00:00

  • Use of PCR serum in diagnosing and monitoring cytomegalovirus reactivation in bone marrow transplant recipients.

    abstract::We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:

    authors: Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

    更新日期:1999-02-01 00:00:00

  • Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.

    abstract::A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/BF02982029

    authors: Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

    更新日期:2002-02-01 00:00:00

  • The effect of adding rituximab to CHOP-based therapy on clinical outcomes for Japanese patients with diffuse large B-cell lymphoma: a propensity score matching analysis.

    abstract::We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0259-8

    authors: Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

    更新日期:2009-04-01 00:00:00

  • Incidence, risk factors, and treatment outcome of symptomatic osteonecrosis in Taiwanese children with acute lymphoblastic leukemia: a retrospective cohort study of 245 patients in a single institution.

    abstract::Osteonecrosis (ON) is a potentially disabling complication encountered in children who receive chemotherapy for acute lymphoblastic leukemia (ALL). Considering the possible effect of ethnic difference on the clinical features of symptomatic ON in pediatric ALL, we retrospectively evaluated 245 children with ALL who we...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1790-4

    authors: Chen SH,Chang TY,Jaing TH,Lee MS,Wang CJ,Hung IJ,Yang CP

    更新日期:2015-07-01 00:00:00

  • Synchronous presentation of Epstein-Barr virus-associated Hodgkin's disease and adult T-cell leukemia/lymphoma (ATLL) in a patient from an endemic area of ATLL.

    abstract::We report a patient from an endemic area of adult T-cell leukemia/lymphoma (ATLL), who developed lymphoma with features characteristic of Hodgkin's disease (HD). Large atypical Reed-Sternberg/Hodgkin's cells (RS/H cells) had a CD3-CD15+CD20-CD30+CD45RO- immunophenotype. Epstein-Barr virus (EBV) latent membrane protein...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(95)00365-y

    authors: Hayashi T,Yamabe H,Haga H,Akasaka T,Kadowaki N,Ohno H,Okuma M,Fukuhara S

    更新日期:1995-06-01 00:00:00

  • Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases.

    abstract::Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-013-1449-y

    authors: Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

    更新日期:2013-11-01 00:00:00

  • DNA methylation as a therapeutic target in hematologic disorders: recent results in older patients with myelodysplasia and acute myeloid leukemia.

    abstract::DNA methylation provides a major epigenetic code (besides histone modification) of the lineage- and development-specific genes (such as regulators of differentiation in the hematopoietic lineages) that control expression of normal cells. However, DNA methylation is also involved in malignancies because aberrant methyl...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1532/ijh97.04094

    authors: Rüter B,Wijermans PW,Lübbert M

    更新日期:2004-08-01 00:00:00

  • Acquired sideroblastic anaemia induced by a copper-chelating agent.

    abstract::Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1016/0925-5710(96)00457-4

    authors: Perry AR,Pagliuca A,Fitzsimons EJ,Mufti GJ,Williams R

    更新日期:1996-07-01 00:00:00

  • Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin.

    abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-010-0741-3

    authors: Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

    更新日期:2011-01-01 00:00:00

  • MALT lymphoma of the thymus with Sjögren's syndrome: biphasic changes in serological abnormalities over a 4-year period following thymectomy.

    abstract::Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-009-0324-3

    authors: Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

    更新日期:2009-06-01 00:00:00

  • Early lymphocyte recovery predicts clinical outcome after HSCT with mycophenolate mofetil prophylaxis in the Japanese population.

    abstract::Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-018-2437-z

    authors: Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

    更新日期:2018-07-01 00:00:00

  • Immune dysregulation syndrome with de novo CTLA4 germline mutation responsive to abatacept therapy.

    abstract::Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-020-02834-9

    authors: Ureshino H,Koarada S,Kamachi K,Yoshimura M,Yokoo M,Kubota Y,Ando T,Ichinohe T,Morio T,Kimura S

    更新日期:2020-06-01 00:00:00

  • Decrease of B-type natriuretic peptide to less than 200 pg/mL predicts longer survival in cardiac immunoglobulin light chain amyloidosis.

    abstract::Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1007/s12185-015-1814-0

    authors: Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

    更新日期:2015-08-01 00:00:00

  • Bone marrow transplantation with a reduced-intensity conditioning regimen in a patient with Wegener granulomatosis and therapy-related leukemia.

    abstract::We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...

    journal_title:International journal of hematology

    pub_type: 杂志文章

    doi:10.1532/IJH97.05148

    authors: Kunitomi A,Ishikawa T,Tajima K,Konaka Y,Yagita M

    更新日期:2006-04-01 00:00:00

  • Targeting autophagy in lymphomas: a double-edged sword?

    abstract::Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in nor...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审

    doi:10.1007/s12185-018-2414-6

    authors: Zhang H

    更新日期:2018-05-01 00:00:00