Abstract:
:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan. Patients with CAD (at least three claims with a CAD diagnosis; Japanese Disease Code 2830009) and non-CAD controls were retrospectively identified (2008-2017) from a large hospital-based administrative claims dataset in Japan. Cohorts were compared using conditional logistic regression. We identified 344 patients with CAD (53.2% female; mean age: 66.8 years) and 3440 matched controls. Patients with CAD had higher TE rates than controls (34.9% vs. 17.9%; P < 0.0001). Both arterial and venous TEs were increased in the CAD group when compared with the control group (25.0% vs. 4.6% and 8.4% vs. 4.0%, respectively; both P < 0.0001). Most arterial TEs in the CAD cohort (87.2%) were myocardial infarctions. The overall odds ratio for TE development in CAD was 2.81 (95% confidence interval 2.18-3.61). CAD in Japan is characterized by an increased risk of TE. The rate of arterial TEs was particularly high in this patient population.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Ydoi
10.1007/s12185-020-02899-6subject
Has Abstractpub_date
2020-09-01 00:00:00pages
307-315issue
3eissn
0925-5710issn
1865-3774pii
10.1007/s12185-020-02899-6journal_volume
112pub_type
杂志文章abstract::The HOX genes are key determinants of cellular identity both in early development and in the renewal and differentiation of adult blood cells. Although a number of studies have examined the expression of individual HOX genes in defined blood cell lineages, we have undertaken a comprehensive analysis of HOX gene expres...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0057-8
更新日期:2008-04-01 00:00:00
abstract::We constructed a "biomimetic osteoblast niche" with bio-derived bone as a scaffold, on which we seeded marrow mesenchymal stem cells (MSCs) from CML patients, and induced the MSCs to differentiate into osteoblasts. Bone marrow mononuclear cells from CML patients were cultured in the biomimetic niche (3D culture system...
journal_title:International journal of hematology
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doi:10.1007/s12185-009-0392-4
更新日期:2009-10-01 00:00:00
abstract::Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The pa...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-013-1323-y
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abstract::To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2446-y
更新日期:2018-08-01 00:00:00
abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982789
更新日期:2002-10-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982811
更新日期:2002-12-01 00:00:00
abstract::According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-014-1670-3
更新日期:2015-03-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1873-2
更新日期:2015-12-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.a10315
更新日期:2004-05-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05098
更新日期:2006-06-01 00:00:00
abstract::Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s12185-013-1383-z
更新日期:2013-08-01 00:00:00
abstract::The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1368-y
更新日期:2013-08-01 00:00:00
abstract::We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-02-01 00:00:00
abstract::A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982029
更新日期:2002-02-01 00:00:00
abstract::We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0259-8
更新日期:2009-04-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1790-4
更新日期:2015-07-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(95)00365-y
更新日期:1995-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1449-y
更新日期:2013-11-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/ijh97.04094
更新日期:2004-08-01 00:00:00
abstract::Acquired sideroblastic anaemia may be related to drugs and other chemicals that inhibit the activity of mitochondrial enzymes involved in haem synthesis. We report a case of secondary acquired sideroblastic anaemia following administration of triethylene tetramine dihydrochloride (trientine), a second-line copper-chel...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/0925-5710(96)00457-4
更新日期:1996-07-01 00:00:00
abstract::B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0741-3
更新日期:2011-01-01 00:00:00
abstract::Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0324-3
更新日期:2009-06-01 00:00:00
abstract::Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2437-z
更新日期:2018-07-01 00:00:00
abstract::Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02834-9
更新日期:2020-06-01 00:00:00
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journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1814-0
更新日期:2015-08-01 00:00:00
abstract::We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.05148
更新日期:2006-04-01 00:00:00
abstract::Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in nor...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-018-2414-6
更新日期:2018-05-01 00:00:00