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Symptomatic severe hypertriglyceridaemia with asparaginase therapy in acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma: is rechallenging safe?

Abstract：

:Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of the patients showed signs or symptoms of pancreatitis. Three children were re-exposed with Peg asparaginase, and one with Erwinia asparaginase, without recurrence of hyperlipidaemia or other symptoms. These cases highlight the dilemma in managing such rare cases of symptomatic hypertriglyceridaemia secondary to asparaginase and steroid therapy.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

doi

10.1007/s12185-011-0966-9

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

571-5

issue

6

eissn

0925-5710

issn

1865-3774

journal_volume

94

pub_type

杂志文章

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