当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Biology of normal and acute myeloid leukemia stem cells.

Biology of normal and acute myeloid leukemia stem cells.

Abstract：

:The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse because the ease with which repopulation studies can be carried out with this animal model allows the assay of complete lineage development from stem cells. In the past decade, advances in repopulation assays for human stem cells using xenotransplantation have greatly enhanced our understanding of human stem cell biology. Importantly, the xenotransplantation methodology has also been used to identify the cancer stem cell that initiates and sustains leukemic proliferation, providing key evidence for the cancer stem cell hypothesis. This hypothesis argues that cancer cells are functionally heterogeneous and hierarchically organized such that only specific cells are capable of sustaining tumor growth and continuously producing the cells that make up the bulk of the tumor. Recent studies have also brought into focus the importance of the intimate relationship between the stem cell (normal or leukemic) and its microenvironment. Coming into view are the molecular players involved in stem cell homing, migration, and adhesion, as well as the cellular components of the microenvironmental niche. Here we review recent studies that have begun, to elucidate the interplay between normal and leukemic human stem cells and their microenvironment.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Dick JE,Lapidot T

doi

10.1532/IJH97.05144

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

389-96

issue

5

eissn

0925-5710

issn

1865-3774

pii

5821F5F260JHJY3G

journal_volume

82

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Molecular basis of beta-thalassemia minor in Taiwan.

    abstract：:The mutations producing beta-thalassemia minor in 227 Taiwanese were studied using the method of naturally and amplified created restriction sites. beta-Thalassemia minor was caused by one beta-globin gene mutation in most of the cases (225/227); only a few cases were caused by two gene mutation (2/227). The most comm...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Chang JG,Lin CP,Liu TC,Chiou SS,Chen PH,Lee LS,Chen TP

    更新日期：1994-06-01 00:00:00

  • An infant with both autoimmune neutropenia and idiopathic thrombocytopenia with IgG2/IgA deficiency.

    abstract：:We report an infant with autoimmune neutropenia (AIN), idiopathic thrombocytopenia (ITP), and IgG2/IgA deficiency. The patient was referred to our hospital at 5 months of age because of epistaxis and generalized petechiae. Physical examination revealed moderate hepatosplenomegaly. A complete blood count revealed a pla...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Sugita K,Owada Y,Ozawa T,Sakakibara H,Eguchi M,Furukawa T,Saitoh K

    更新日期：1993-01-01 00:00:00

  • Modified immunosuppressive therapy with porcine antilymphocyte globulin plus delayed cyclosporine A in children with severe aplastic anemia.

    abstract：:Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less exp...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-017-2321-2

    authors： Cui Q,Sha P,Chen H,Shen H,Qin L,Li Z,Wu T,Wang Z

    更新日期：2018-01-01 00:00:00

  • Early lymphocyte recovery predicts clinical outcome after HSCT with mycophenolate mofetil prophylaxis in the Japanese population.

    abstract：:Immune reconstitution affects clinical outcomes after allogeneic hematopoietic stem cell transplantation (HSCT), and it has been suggested that lymphocyte recovery affects survival after HSCT. However, few studies have examined lymphocyte recovery in Asian patients who received mycophenolate mofetil (MMF) prophylaxis ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2437-z

    authors： Kurata K,Yakushijin K,Mizuno I,Gomyo H,Okamura A,Ichikawa H,Sakai R,Mizutani Y,Kakiuchi S,Miyata Y,Kitao A,Sanada Y,Inui Y,Uryu K,Kawamoto S,Sugimoto T,Yamamoto K,Ito M,Matsuoka H,Murayama T,Minami H

    更新日期：2018-07-01 00:00:00

  • Successful allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by severe pulmonary alveolar proteinosis.

    abstract：:Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the abnormal accumulation of alveolar surfactant protein in alveolar spaces. We report herein a rare case of myelodysplastic syndrome (MDS-RAEB) complicated by severe PAP, and successful allogeneic bone marrow transplantation (BMT) for both disor...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0404-4

    authors： Tabata S,Shimoji S,Murase K,Takiuchi Y,Inoue D,Kimura T,Nagai Y,Mori M,Togami K,Kurata M,Ito K,Hashimoto H,Matushita A,Nagai K,Takahashi T

    更新日期：2009-10-01 00:00:00

  • Systemic HD-MTX for CNS prophylaxis in high-risk DLBCL patients: a prospectively collected, single-center cohort analysis.

    abstract：:We evaluated the efficacy of systemic high-dose methotrexate (HD-MTX) for CNS prophylaxis in a prospectively recruited cohort of DLBCL patients at high risk of CNS relapse. High-risk CNS relapse was defined as the involvement of ≥ 2 extranodal sites with elevated lactate dehydrogenase (LDH); CNS international prognost...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02653-7

    authors： Lee K,Yoon DH,Hong JY,Kim S,Lee K,Kang EH,Huh J,Park CS,Lee SW,Suh C

    更新日期：2019-07-01 00:00:00

  • A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission.

    abstract：:We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1729-1

    authors： Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

    更新日期：2015-05-01 00:00:00

  • Calcineurin inhibitor-induced irreversible neuropathic pain after allogeneic hematopoietic stem cell transplantation.

    abstract：:The calcineurin inhibitors (CIs) cyclosporine A and tacrolimus are essential for graft-versus-host disease prophylaxis but are associated with adverse effects, including neurotoxicity. We report a case of irreversible CI-induced neuropathic pain following allogeneic hematopoietic stem cell transplantation. The patient...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.05154

    authors： Fujii N,Ikeda K,Koyama M,Aoyama K,Masunari T,Kondo E,Matsuzaki T,Mizobuchi S,Hiraki A,Teshima T,Shinagawa K,Ishimaru F,Tanimoto M

    更新日期：2006-06-01 00:00:00

  • Primary mediastinal large B-cell lymphoma in Japanese children and adolescents.

    abstract：:This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2147-3

    authors： Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

    更新日期：2017-04-01 00:00:00

  • Involvement of the BCL3 gene in two patients with chronic lymphocytic leukemia.

    abstract：:The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Yabumoto K,Ohno H,Doi S,Edamura S,Arita Y,Akasaka T,Matsumoto J,Kadowaki N,Fukuhara S,Okuma M

    更新日期：1994-04-01 00:00:00

  • Peroxisome proliferator-activated receptor gamma and retinoic acid receptor synergistically up-regulate the tumor suppressor PTEN in human promyeloid leukemia cells.

    abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.A30615

    authors： Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

    更新日期：2007-04-01 00:00:00

  • Successful repeated treatment of acute myeloid leukemia in early relapse with gemtuzumab ozogamicin alone.

    abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1481-y

    authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

    更新日期：2014-02-01 00:00:00

  • Signal transduction in macrophages: negative regulation for macrophage colony-stimulating factor receptor signaling.

    abstract：:The receptor for macrophage colony-stimulating factor (M-CSF) is expressed in monocytes/macrophages and their progenitor cells and stimulates both the growth and development of the blood-cell lineage. Although the specific components positively regulating M-CSF receptor signaling have been relatively well defined, it ...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF02982712

    authors： Suzu S,Motoyoshi K

    更新日期：2002-07-01 00:00:00

  • Prognostic value of early response to treatment combined with conventional risk factors in pediatric acute lymphoblastic leukemia.

    abstract：:To determine useful prognostic factors in treating childhood acute lymphoblastic leukemia (ALL), we correlated conventional risk factors and bone marrow response 14 days after induction chemotherapy. Our study included 116 precursor B-cell (n = 104) and T-cell (n = 12) ALL patients treated with our protocol between 19...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/ijh97.04114

    authors： Morimoto A,Kuriyama K,Hibi S,Todo S,Yoshihara T,Kuroda H,Imashuku S

    更新日期：2005-04-01 00:00:00

  • Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma.

    abstract：:IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-017-2315-0

    authors： Bielska M,Borowiec M,Jesionek-Kupnicka D,Braun M,Bojo M,Pastorczak A,Kalinka-Warzocha E,Prochorec-Sobieszek M,Robak T,Warzocha K,Młynarski W,Lech-Marańda E

    更新日期：2017-12-01 00:00:00

  • Efficacy and safety of a 4-factor prothrombin complex concentrate for rapid vitamin K antagonist reversal in Japanese patients presenting with major bleeding or requiring urgent surgical or invasive procedures: a prospective, open-label, single-arm phase

    abstract：:Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex®/Kcentra®) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for ur...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-017-2311-4

    authors： Kushimoto S,Fukuoka T,Kimura A,Toyoda K,Brainsky A,Harman A,Chung T,Yasaka M

    更新日期：2017-12-01 00:00:00

  • Hematopoietic stem cell transplantation for therapy-related myelodysplastic syndrome and acute leukemia: a single-center analysis of 47 patients.

    abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0640-7

    authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

    更新日期：2010-09-01 00:00:00

  • Aplastic anemia with circulating erythroblasts.

    abstract：:Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Yokose N,Ogata K,Dan K,Nomura T

    更新日期：1994-08-01 00:00:00

  • B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma.

    abstract：:Waldenstroem's macroglobulinemia is usually closely related to a histopathologic subtype called lymphoplasmacytoid lymphoma in the Revised European-American Lymphoma (REAL) classification. Here, we report a case of B-cell lymphoma accompanied by monoclonal macroglobulinemia and pathologically compatible with marginal ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1016/s0925-5710(96)00565-8

    authors： Nakata M,Matsuno Y,Takenaka T,Kobayashi Y,Takeyama K,Yokozawa T,Tobinai K

    更新日期：1997-06-01 00:00:00

  • A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia.

    abstract：:We identified a novel gene fusion of ANKRD28 (ankyrin repeat domain 28) on 3p25 to NUP98 on 11p15 in a patient with adult myelodysplastic syndrome/acute myelogenous leukemia. A partially cryptic 3-way translocation, t(3;5;11)(p25;q35;p15), that had initially been supposed to be t(3;5)(p25;q35) was revealed by precise ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.07054

    authors： Ishikawa M,Yagasaki F,Okamura D,Maeda T,Sugahara Y,Jinnai I,Bessho M

    更新日期：2007-10-01 00:00:00

  • Concurrent development of "Burkitt-like" lymphoma and BCL-2-rearranged low-grade B cell lymphoma sharing the same germinal center origin.

    abstract：:B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma (BL) is a new entity in WHO classification 2008, and includes Burkitt-like transformation of follicular lymphoma (FL). However, the pathological significance of BCL-2/IgH translocation, which is chara...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0741-3

    authors： Kobayashi H,Ichikawa M,Hangaishi A,Imai Y,Kurokawa M

    更新日期：2011-01-01 00:00:00

  • Clinical significance of jejunoileal involvement of non-Hodgkin's lymphoma detected by double-balloon enteroscopy.

    abstract：:Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1273-4

    authors： Ibuka T,Tsurumi H,Araki H,Hara T,Onogi F,Goto N,Kojima Y,Kanemura N,Shiraki M,Kasahara S,Shimizu M,Ogawa K,Ninomiya S,Nakanishi T,Kato T,Takami T,Moriwaki H

    更新日期：2013-03-01 00:00:00

  • Allogeneic bone marrow transplantation of chronic myeloid leukemia from an HLA-matched unrelated donor with the beta-thalassemic trait.

    abstract：:We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reactio...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Sue YC,Liu TC,Chang CS,Huang SM,Chen TP,Lin SF

    更新日期：1999-04-01 00:00:00

  • Constitutively activated Rho guanosine triphosphatases regulate the growth and morphology of hairy cell leukemia cells.

    abstract：:Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983784

    authors： Zhang X,Machii T,Matsumura I,Ezoe S,Kawasaki A,Tanaka H,Ueda S,Sugahara H,Shibayama H,Mizuki M,Kanakura Y

    更新日期：2003-04-01 00:00:00

  • Myeloid/natural killer cell precursor acute leukemia accompanied by homozygous protein C deficiency.

    abstract：:A patient with myeloid/natural killer (NK) cell precursor acute leukemia who was also homozygous for protein C deficiency was treated and showed a complete remission while he simultaneously received low molecular weight heparin. He presented with fever spikes, lymphadenopathy, and a bulky tumor of the anterior mediast...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983384

    authors： Shimamoto T,Nakajima A,Katagiri T,Ito Y,Ohyashiki K

    更新日期：2003-08-01 00:00:00

  • T cell acute lymphoblastic leukemia arising from familial platelet disorder.

    abstract：:Familial platelet disorder (FPD) is a rare autosomal dominant disorder which causes moderate thrombocytopenia with or without impaired platelet function. Patients have a propensity to develop acute myeloid leukemia (AML), and various types of second hits have been postulated in the evolution to AML. However, only a fe...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0612-y

    authors： Nishimoto N,Imai Y,Ueda K,Nakagawa M,Shinohara A,Ichikawa M,Nannya Y,Kurokawa M

    更新日期：2010-07-01 00:00:00

  • Evi-1 as a critical regulator of leukemic cells.

    abstract：:Ecotropic viral integration site-1 (EVI-1) has been recognized as one of the dominant oncogenes associated with murine and human myeloid leukemia. Recent clinical studies demonstrated that high EVI-1 expression was an independent negative prognostic indicator of survival in leukemia patients. In addition, gene-targeti...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-010-0618-5

    authors： Goyama S,Kurokawa M

    更新日期：2010-06-01 00:00:00

  • X-linked lymphoproliferative disease in an adult.

    abstract：:X-linked lymphoproliferative disease (XLP) is an inherited immunodeficiency characterized by an extreme susceptibility to Epstein-Barr virus (EBV) infection. Patients with XLP mainly present with the 3 clinical manifestations of fulminant infectious mononucleosis, lymphoproliferative disorder, and dysgammaglobulinemia...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.05020

    authors： Hoshino T,Kanegane H,Doki N,Irisawa H,Sakura T,Nojima Y,Miyawaki S,Miyawaki T

    更新日期：2005-07-01 00:00:00

  • Prognostic value of Waldeyer's ring involvement of diffuse large B-cell lymphoma treated with R-CHOP.

    abstract：:The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluo...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1282-3

    authors： Oh MY,Chung JS,Song MK,Shin HJ,Lee HS,Lee SM,Lee GW,Lee SE

    更新日期：2013-03-01 00:00:00

  • Successful treatment of Aspergillus liver abscesses in a patient with acute monoblastic leukemia using combination antifungal therapy including micafungin as a key drug.

    abstract：:While anti-cancer chemotherapy has improved the survival of patients with hematologic malignancies, it has also exposed such patients to the risk of life-threatening infection due to neutropenia. In intensive chemotherapy for leukemia, invasive aspergillosis resulting in death is infrequently observed. In such cases, ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0556-2

    authors： Yamada R,Horikawa K,Ishihara S,Hoshino K,Kawaguchi T,Iyama K,Mitsuya H,Asou N

    更新日期：2010-05-01 00:00:00