Aging of the hematopoietic stem cells niche.

abstract：:The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disease characteristics ...

journal_title：International journal of hematology

authors： Webb MJ,Barrett CL,Pretorius C,van Jaarsveld MF,Louw VJ

更新日期：2012-05-01 00:00:00

abstract：:The standard therapy for anti-erythropoietin (EPO) antibody-mediated pure red cell aplasia (PRCA) is cyclosporine (CyA) or prednisolone (PSL) 0.5-1.0 mg/kg. However, many patients with severe chronic kidney disease (CKD) and chronic heart failure cannot tolerate such an immunosuppressive regimen. An 86-year-old man wi...

journal_title：International journal of hematology

authors： Aoki K,Ono Y,Tabata S,Matsushita A,Ishikawa T

更新日期：2013-02-01 00:00:00

abstract：:Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

journal_title：International journal of hematology

authors： Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

更新日期：2017-03-01 00:00:00

abstract：:There has been important progress in the treatment of Acute Myeloid Leukaemia (AML) in patients under 60 years. A remission rate of 80% can be achieved by several schedules, and 40-45% of patients diagnosed will survive. It may still be possible to improve remission induction treatment eg by intensifying the Ara-C dos...

journal_title：International journal of hematology

authors： Newland A

更新日期：2002-08-01 00:00:00

abstract：:A.R.R.O.W. evaluated the superiority of once-weekly carfilzomib plus dexamethasone (Kd) 20/70 mg/m2 vs. twice-weekly Kd 20/27 mg/m2 based on progression-free survival (PFS) in relapsed and/or refractory multiple myeloma patients. Forty Japanese patients (once-weekly arm, n = 26; twice-weekly arm, n = 14) were randomiz...

journal_title：International journal of hematology

authors： Takezako N,Shibayama H,Handa H,Hagiwara S,Ozaki S,Suzuki K,Kosugi H,Ri M,Sugiura I,Choi I,Miyamoto T,Iida S

更新日期：2020-10-10 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers,...

journal_title：International journal of hematology

authors： Ikeda S,Tagawa H

更新日期：2014-01-01 00:00:00

abstract：:Patients with severe congenital protein (P)C deficiency require long-term anticoagulant management. Recombinant PC concentrates for prophylactic use are not available in Japan; prothrombin complex concentrates (PCC), containing factors (F)II, VII, IX, X, and PC (PPSB-HT®), have been used 'off-label' in a few patients....

journal_title：International journal of hematology

authors： Ogiwara K,Nogami K,Mizumachi K,Nakagawa T,Noda N,Ohga S,Shima M

更新日期：2019-06-01 00:00:00

abstract：:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second...

journal_title：International journal of hematology

authors： Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M

更新日期：2008-12-01 00:00:00

abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

journal_title：International journal of hematology

authors： Kikuchi J,Koyama D,Mukai HY,Furukawa Y

更新日期：2014-06-01 00:00:00

abstract：:We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

journal_title：International journal of hematology

authors： Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

更新日期：2006-06-01 00:00:00

abstract：:Elderly/comorbid patients with chronic lymphocytic leukemia (CLL) require low-toxicity treatments. Internationally, the standard treatment for such patients is chlorambucil and an anti-CD20 therapy; however, chlorambucil is not approved in Japan. The aim of the present study was to evaluate the safety, efficacy and ph...

journal_title：International journal of hematology

authors： Hatake K,Ogura M,Takada K,Taniwaki M,Zhang F,Fujita T,Ando K

更新日期：2017-08-01 00:00:00

abstract：:Fas stimulation has been reported to promote the activation and proliferation of T lymphocytes, but the intracellular signalling pathways that mediate non-apoptotic responses to Fas are poorly defined. To distinguish between the activation signalling and the death-inducing pathway downstream of Fas, we generated a nov...

journal_title：International journal of hematology

authors： Shin MJ,Shim JH,Lee JY,Chae WJ,Lee HK,Morio T,Park JH,Chang EJ,Lee SK

更新日期：2010-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARgamma) and retinoic acid receptors (RARs) have been a focus in chemotherapy for human cancers. The tumor suppressor PTEN plays a pivotal role in the growth of human cancer cells. We investigated whether costimulation of PPARgamma and RAR could synergistically up-re...

journal_title：International journal of hematology

authors： Lee YR,Yu HN,Noh EM,Kim JS,Song EK,Han MK,Kim BS,Lee SH,Park J

更新日期：2007-04-01 00:00:00

abstract：:The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts ar...

journal_title：International journal of hematology

authors： Tominaga-Sato S,Tsushima H,Ando K,Itonaga H,Imaizumi Y,Imanishi D,Iwanaga M,Taguchi J,Fukushima T,Yoshida S,Hata T,Moriuchi Y,Kuriyama K,Mano H,Tomonaga M,Miyazaki Y

更新日期：2011-07-01 00:00:00

abstract：:A 56-year-old woman with acute myelomonocytic leukemia underwent myeloablative allogeneic hematopoietic stem cell transplantation (allo-SCT) from a matched unrelated donor in her first complete remission (CR). Veno-occlusive disease (VOD) prophylaxis consisted of low-dose heparin and ursodeoxycholic acid. Graft-versus...

journal_title：International journal of hematology

authors： Sumi M,Ichikawa N,Nasu K,Shimizu I,Ueki T,Ueno M,Kobayashi H

更新日期：2009-12-01 00:00:00

abstract：:At present, the only 2 treatments that can prolong survival in patients with myelodysplastic syndrome (MDS) are allogeneic stem cell transplantation and intensive chemotherapy. Alternatives to myeloablative or conventional chemotherapy include: (1) supportive therapy, (2) stimulation of normal residual hematopoietic p...

journal_title：International journal of hematology

authors： Cazzola M

更新日期：2000-08-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CL...

journal_title：International journal of hematology

authors： Xu W,Cao X,Miao KR,Qiao C,Wu YJ,Liu Q,Fan L,Li JY

更新日期：2009-09-01 00:00:00

abstract：:TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several c...

journal_title：International journal of hematology

authors： Masaki Y,Kawabata H,Takai K,Kojima M,Tsukamoto N,Ishigaki Y,Kurose N,Ide M,Murakami J,Nara K,Yamamoto H,Ozawa Y,Takahashi H,Miura K,Miyauchi T,Yoshida S,Momoi A,Awano N,Ikushima S,Ohta Y,Furuta N,Fujimoto S,Ka

更新日期：2016-06-01 00:00:00

abstract：:We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months a...

journal_title：International journal of hematology

authors： Yamamoto M,Kakihana K,Ohashi K,Yamaguchi T,Tadokoro K,Akiyama H,Sakamaki H

更新日期：2009-05-01 00:00:00

abstract：:Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

journal_title：International journal of hematology

authors： Asma S,Boga C,Ozdogu H

更新日期：2009-07-01 00:00:00

abstract：:Pluripotent stem cells of hematopoiesis are included among CD34+ cells in the blood and bone marrow. After granulocyte-colony stimulating factor (G-CSF) mobilization, 1-2% of the mononuclear cells in the blood are CD34+ cells, which can be obtained by leukapheresis. We performed CD34+ progenitor cell transplantation i...

journal_title：International journal of hematology

authors： Yasui M,Park YD,Okamura T,Chayama K,Yoshimoto T,Inoue M,Yagi K,Kawa K

更新日期：1998-01-01 00:00:00

abstract：:Antibodies represent a unique class of therapeutics because of their high specificity toward a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an upsurge in the development of these agents. Antibodies directed against FLT3 represent a promising approach for the treatm...

journal_title：International journal of hematology

authors： Li Y,Zhu Z

更新日期：2005-08-01 00:00:00

abstract：:Severe congenital neutropenia (SCN) is characterized by a maturation arrest of myeloid progenitor cells at the stage of promyelocytes in bone marrow and low levels of mature neutrophils in peripheral blood. To date, little is known regarding the underlying pathomechanism of SCN. A defective response of neutrophil prec...

journal_title：International journal of hematology

authors： Kasper B,Tidow N,Welte K

更新日期：1999-12-01 00:00:00

abstract：:Platelet activation, impairment of fibrinolysis, activation of the coagulation pathway, and dyslipidemia are important factors in the pathogenesis and progression of ischemic heart disease, and patients generally need to use an antiplatelet agent. Lipid-lowering cerivastatin, a novel 3-hydroxy-3-methylglutaryl coenzym...

journal_title：International journal of hematology

authors： Ural AU,Yilmaz MI,Avcu F,Yalcin A

更新日期：2002-10-01 00:00:00

abstract：:A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

journal_title：International journal of hematology

authors： Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

更新日期：1999-07-01 00:00:00

abstract：:Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

journal_title：International journal of hematology

authors： de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

更新日期：2011-02-01 00:00:00

abstract：:Since its discovery from a translocation in leukemias, the runt-related transcription factor 1/acute myelogenous leukemia-1 (RUNX1/AML1), which is widely expressed in hematopoietic cells, has been extensively studied. Many lines of evidence have shown that RUNX1 plays a critical role in regulating the development and ...

journal_title：International journal of hematology

authors： Ichikawa M,Yoshimi A,Nakagawa M,Nishimoto N,Watanabe-Okochi N,Kurokawa M

更新日期：2013-06-01 00:00:00

abstract：:Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of...

journal_title：International journal of hematology

authors： Nomoto H,Takami A,Espinoza JL,Matsuo K,Mizuno S,Onizuka M,Kashiwase K,Morishima Y,Fukuda T,Kodera Y,Doki N,Miyamura K,Mori T,Nakao S,Ohtake S,Morishita E

更新日期：2015-10-01 00:00:00

abstract：:The widespread use of tissue including hematopoietic stem cell products is justification for the development of standards by professional societies and for regulation by governmental agencies. The Food and Drug Administration (FDA) developed a tiered, risk-based regulatory model. At the low end of risk to the tissue r...

journal_title：International journal of hematology

authors： Rowley SD

更新日期：2002-04-01 00:00:00

abstract：:A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

journal_title：International journal of hematology

authors： Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

更新日期：2002-02-01 00:00:00