当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.

Treatment of a child with myeloid/NK cell precursor acute leukemia with L-asparaginase and unrelated cord blood transplantation.

Abstract：

:A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myeloid marker), CD34, and HLA-DR. Tumor cells in a lymph node were also positive for CD2, cytoplasmic CD3 (T-cell marker), CD7, CD33, CD34, and CD56, but negative for peroxidase staining and other T-cell, NK, and myeloid markers. Southern blot analysis showed no rearrangement bands for T-cell receptor delta and immunoglobulin heavy chain. Chromosomal analysis revealed 46,XY,inv(7)(p21q21). Neither chemotherapy for acute lymphoblastic leukemia nor that for acute myeloid leukemia induced remission in this patient. However, complete remission was achieved by the administration of L-asparaginase (6,000 U/m2 for 5 days). Because the disease was considered refractory to standard chemotherapy, cord blood transplantation was performed from an HLA 1-locus mis-matched unrelated donor. The conditioning regimen consisted of total body irradiation, cytarabine, and cyclophosphamide, and cyclosporine and short-term methotrexate were employed for graft-versus-host disease (GVHD) prophylaxis. Hematological reconstitution was rapid, and only grade I acute GVHD was observed. The patient has been in remission for more than 24 months after transplantation. Our findings indicate that combination therapy with L-asparaginase and allogeneic stem cell transplantation may be useful for the treatment of myeloid/NK cell precursor acute leukemia.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

doi

10.1007/BF02982029

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

201-6

issue

2

eissn

0925-5710

issn

1865-3774

journal_volume

75

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • Biology of normal and acute myeloid leukemia stem cells.

    abstract：:The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse be...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.05144

    authors： Dick JE,Lapidot T

    更新日期：2005-12-01 00:00:00

  • Spontaneous improvement of chronic immune thrombocytopenia in children: experience of 56 patients at a single institute.

    abstract：:Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1211-x

    authors： Kato M,Koh K,Kikuchi A,Hanada R

    更新日期：2012-12-01 00:00:00

  • EBV-positive PEL-like lymphoma that developed in the course of antisynthetase syndrome treated with tacrolimus.

    abstract：:Primary effusion lymphoma (PEL) is a rare type of extranodal lymphoma, typically of a B-cell origin, which presents as lymphomatous effusion with no nodal enlargement or tumor masses. The development PEL is universally associated with human herpes virus-8 (HHV-8) infection. Cases of HHV-8-negative primary lymphomatous...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-018-2426-2

    authors： Okada K,Asakura S,Yano T,Kishimoto T

    更新日期：2018-09-01 00:00:00

  • MALT lymphoma of the thymus with Sjögren's syndrome: biphasic changes in serological abnormalities over a 4-year period following thymectomy.

    abstract：:Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0324-3

    authors： Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

    更新日期：2009-06-01 00:00:00

  • Pathophysiology and treatment of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS).

    abstract：:The central pathogenic feature of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is the formation of platelet aggregates, perhaps by damaged endothelial cells. The evidence for endothelial cell damage has been supported by multiple findings, including the harmful effects of TTP/HUS plasma, whi...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：

    authors： Kakishita E

    更新日期：2000-06-01 00:00:00

  • A chronic myeloid leukemia patient with atypical karyotype and BCR-ABL e13a3 transcript caused by complex chromosome rearrangement.

    abstract：:Philadelphia (Ph) chromosome as a result of t (9; 22) (q34; q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients. Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients. CML cases with fusion transcripts such as e13a3 in which ABL exon 3 ra...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0368-4

    authors： Masuko M,Furukawa T,Abe T,Wada R,Maruyama S,Kitajima T,Shibasaki Y,Toba K,Okada M,Aizawa Y

    更新日期：2009-09-01 00:00:00

  • In vivo effects of recombinant human granulocyte colony-stimulating factor on normal neutrophil function and membrane effector molecule expression.

    abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

    更新日期：1991-12-01 00:00:00

  • Serial monitoring of T315I BCR-ABL mutation by Invader assay combined with RT-PCR.

    abstract：:We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0290-9

    authors： Yamamoto M,Kakihana K,Ohashi K,Yamaguchi T,Tadokoro K,Akiyama H,Sakamaki H

    更新日期：2009-05-01 00:00:00

  • An unusual case of transient dermatological reaction to bortezomib in AL amyloidosis.

    abstract：:We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0460-9

    authors： Shah AD,Watts AJ,Mehta AB,Wechalekar AD

    更新日期：2010-01-01 00:00:00

  • Molecular basis of clonal evolution in multiple myeloma.

    abstract：:The treatment outcome of multiple myeloma (MM) is worse than expected from the average numbers of non-synonymous mutations, which are roughly correlated with the prognosis of cancer patients. The refractoriness of MM may be ascribed to the complex genomic architecture and clonal behavior of the disease. In MM, disease...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-020-02829-6

    authors： Furukawa Y,Kikuchi J

    更新日期：2020-04-01 00:00:00

  • Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma.

    abstract：:Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six p...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1260-9

    authors： Yoo C,Yoon DH,Kim JE,Jo J,Park SJ,Yoon SK,Ahn Y,Kim S,Huh J,Lee DH,Suh C

    更新日期：2013-02-01 00:00:00

  • Increase in plasma thrombin-activatable fibrinolysis inhibitor may not contribute to thrombotic tendency in antiphospholipid syndrome because of inhibitory potential of antiphospholipid antibodies toward TAFI activation.

    abstract：:The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0590-0

    authors： Ieko M,Yoshida M,Naito S,Nakabayashi T,Kanazawa K,Mizukami K,Mukai M,Atsumi T,Koike T

    更新日期：2010-06-01 00:00:00

  • Real-world data on the efficacy and safety of daratumumab treatment in Hungarian relapsed/refractory multiple myeloma patients.

    abstract：:Daratumumab is a human anti-CD38 monoclonal antibody used in the treatment of refractory and relapsed multiple myeloma. We investigated the efficacy and safety of daratumumab therapy in a real-world setting. Ninety-nine Hungarian patients were included; 48 received monotherapy, while lenalidomide and bortezomib combin...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02715-w

    authors： Lovas S,Varga G,Farkas P,Masszi T,Wohner N,Bereczki Á,Adamkovich N,Borbényi Z,Szomor Á,Alizadeh H,Szaleczky E,Wolf K,Schneider T,Plander M,Szendrei T,Csacsovszki O,Csukly Z,Rajnics P,Egyed M,Nagy Z,Rejtő L,Illés

    更新日期：2019-11-01 00:00:00

  • The effect of adding rituximab to CHOP-based therapy on clinical outcomes for Japanese patients with diffuse large B-cell lymphoma: a propensity score matching analysis.

    abstract：:We conducted a retrospective analysis to evaluate the impact on clinical outcomes of adding rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) treatment for diffuse large B-cell lymphoma (DLBCL) patients in Japan. A propensity score method was used to compensate for the non-randomized study...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0259-8

    authors： Nishimori H,Matsuo K,Maeda Y,Nawa Y,Sunami K,Togitani K,Takimoto H,Hiramatsu Y,Kiguchi T,Yano T,Yamane H,Tabayashi T,Takeuchi M,Makita M,Sezaki N,Yamasuji Y,Sugiyama H,Tabuchi T,Kataoka I,Fujii N,Ishimaru F,Shin

    更新日期：2009-04-01 00:00:00

  • Correction to: Effect of sertraline on complications and survival after hematopoietic stem-cell transplantation, a double-blind, placebo-controlled clinical study.

    abstract：:The correct name of the corresponding author should be ''Maryam Mehrpooya'', and not ''Mehrpooya Maryam'' as given in the original publication of the article. ...

    journal_title：International journal of hematology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s12185-017-2372-4

    authors： Tavakoli-Ardakani M,Kheshti R,Mehrpooya M

    更新日期：2018-01-01 00:00:00

  • Occurrence of lymphoplasmacytic lymphoma 6 years after amelioration of primary cold agglutinin disease by rituximab therapy.

    abstract：:Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia, classified into primary and secondary types. Secondary CAD accompanies infection or malignant disease, most often lymphoma, whereas primary CAD frequently represents a lymphoproliferative bone marrow disorder characterized by clonal expansion of B ce...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1158-y

    authors： Tanaka H,Hashimoto S,Sugita Y,Sakai S,Takeda Y,Abe D,Takagi T,Nakaseko C

    更新日期：2012-10-01 00:00:00

  • Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak.

    abstract：:The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML). Its expression level in CML patients is monitored by a real-time quantitative polymerase chain reaction defined by the International Scale (qPCRIS). BCR-ABL1 has also been found in asymptomatic normal in...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02768-x

    authors： Kuan JW,Su AT,Tay SP,Fong IL,Kubota S,Su'ut L,Osato M,Sashida G

    更新日期：2020-02-01 00:00:00

  • Clinical significance of anti-endothelial cell antibody in allogeneic hematopoietic stem cell transplantation recipients with graft-versus-host disease.

    abstract：:Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-014-1517-y

    authors： Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

    更新日期：2014-03-01 00:00:00

  • Targeting autophagy in lymphomas: a double-edged sword?

    abstract：:Autophagy (also known as macroautophagy) is a lysosomal degradation pathway for the clearance of cellular materials, which manifests as an adaptive response to stress stimuli. Over the past decade, numerous studies have linked autophagy with cancer initiation, progression, and chemoresistance. Autophagy defects in nor...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-018-2414-6

    authors： Zhang H

    更新日期：2018-05-01 00:00:00

  • Recurrent intramural hematoma of the small intestine in a severe hemophilia A patient with a high titer of factor VIII inhibitor: a case report and review of the literature.

    abstract：:A 17-year-old man with severe hemophilia A (factor VIII <1%) developed intermittent left upper quadrant pain. He had a high titer of factor VIII inhibitor (1024 Bethesda units/mL) and was diagnosed with intramural hematoma of the jejunum. He was managed conservatively with activated prothrombin complex concentrate (AP...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.06053

    authors： Katsumi A,Matsushita T,Hirashima K,Iwasaki T,Adachi T,Yamamoto K,Kojima T,Takamatsu J,Saito H,Naoe T

    更新日期：2006-08-01 00:00:00

  • Successful graft-versus-leukemia effect of second bone marrow transplantation on relapsed leukemia cutis that was refractory to intensive chemotherapy and donor lymphocyte transfusions in a patient with acute monocytic leukemia.

    abstract：:We report a patient with acute monocytic leukemia (AMoL; M5) who received a second bone marrow transplantation (BMT) with graft-versus-leukemia (GVL) effect on relapsed leukemia cutis, which had been refractory to intensive chemotherapy and donor lymphocyte transfusions (DLTs). A 21-year-old woman was diagnosed with A...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Ashida T,Kawanishi K,Ariyama T,Hamasaki H,Maeda Y,Tsubaki K,Kanamaru A

    更新日期：2000-06-01 00:00:00

  • Reduced risk of bacterial infection in multiple myeloma patients with VAD regimen without intermittent high-dose dexamethasone.

    abstract：:Vincristine-adriamycin-dexamethasone (VAD) regimen with intermittent high-dose dexamethasone (HD) has been used as primary chemotherapy for multiple myeloma (MM) patients who are candidates for high-dose therapy or present with renal failure. However, dexamethasone increases the risk of infection in MM patients. We re...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0735-1

    authors： Isoda A,Matsumoto M,Nakahashi H,Mawatari M,Manaka A,Sawamura M

    更新日期：2011-01-01 00:00:00

  • Bone marrow transplantation with a reduced-intensity conditioning regimen in a patient with Wegener granulomatosis and therapy-related leukemia.

    abstract：:We describe a patient with Wegener granulomatosis (WG) who underwent long-term cyclophosphamide treatment and thereafter developed acute myelogenous leukemia (AML). After the AML was induced into remission, the patient received an allogeneic stem cell transplant (allo-SCT) from his sibling after undergoing a reduced-i...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.05148

    authors： Kunitomi A,Ishikawa T,Tajima K,Konaka Y,Yagita M

    更新日期：2006-04-01 00:00:00

  • Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases.

    abstract：:Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-013-1449-y

    authors： Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

    更新日期：2013-11-01 00:00:00

  • An increase in MPC-1- and MPC-1-CD45+ immature myeloma cells in the progressive states of bone marrow plasmacytosis: the revised phenotypic classification of monoclonal marrow plasmacytosis (MOMP-2005).

    abstract：:The heterogeneity of bone marrow plasmacytosis is clearly analyzed by multicolor staining with anti-CD38 antibody. To date, at least 5 subpopulations of plasma cells have been identified in the bone marrow of multiple myeloma (MM) patients with regard to the expression of MPC-1, CD49e (VLA-5), and CD45: MPC-1(-)CD49e(...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.05112

    authors： Otsuyama K,Asaoku H,Kawano MM

    更新日期：2006-01-01 00:00:00

  • Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

    abstract：:Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.06230

    authors： Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini F

    更新日期：2007-07-01 00:00:00

  • Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial.

    abstract：:Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-016-2110-3

    authors： Mori T,Kanda Y,Takenaka K,Okamoto S,Kato J,Kanda J,Yoshimoto G,Gondo H,Doi S,Inaba M,Kodera Y

    更新日期：2017-02-01 00:00:00

  • Chromosomal abnormalities and oncogenes.

    abstract：:The alterations of transcription factor genes by chromosomal translocations play an important role in leukemogenesis and lymphomagenesis. The alterations are classified into two groups. One is the chimeric gene formation, and the other is the aberrant expression without structural changes. The former type is associate...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1016/0925-5710(96)00440-9

    authors： Mitani K

    更新日期：1996-02-01 00:00:00

  • Incidence, risk factors and outcomes of bronchiolitis obliterans after allogeneic stem cell transplantation.

    abstract：:Bronchiolitis obliterans (BO) after allogeneic stem cell transplantation (allo-SCT) is a late-onset, life-threatening respiratory complication that significantly reduces a patient's quality of life. We retrospectively analysed the incidence of and risk factors for BO in allo-SCT recipients. In 2087 patients who underw...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-011-0809-8

    authors： Nakaseko C,Ozawa S,Sakaida E,Sakai M,Kanda Y,Oshima K,Kurokawa M,Takahashi S,Ooi J,Shimizu T,Yokota A,Yoshiba F,Fujimaki K,Kanamori H,Sakai R,Saitoh T,Sakura T,Maruta A,Sakamaki H,Okamoto S

    更新日期：2011-03-01 00:00:00

  • Human cytomegalovirus induces caspase-dependent apoptosis of megakaryocytic CHRF-288-11 cells by activating the JNK pathway.

    abstract：:Human cytomegalovirus (HCMV) infection is usually implicated in thrombocytopenia occurring in newborns and immunocompromised patients. However, the underlying mechanisms remain elusive. This study was conducted to investigate the effects of HCMV infection on the viability of megakaryocytic CHRF-288-11 cells and the un...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-010-0560-6

    authors： Dou J,Li X,Cai Y,Chen H,Zhu S,Wang Q,Zou X,Mei Y,Yang Q,Li W,Han Y

    更新日期：2010-05-01 00:00:00