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Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.

Abstract：

:Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent antioxidant activity. Because EGCG has recently been reported to have a favorable toxicity profile for treating amyloidosis, we sought to examine the clinical efficacy and toxicity of EGCG in patients with AL amyloidosis. Fifty-seven patients were randomly assigned to the EGCG and observation groups and observed for six months. There were no increases in grade 3-5 adverse events and EGCG therapy was well tolerated. Although a decrease in the urinary albumin level was found in the EGCG group in patients with obvious albuminuria after treatment initiation, its antioxidant activity may not be sufficient to clarify the potential effect of EGCG in patients with AL amyloidosis. Because some of the biological markers responsible for organ damage were well correlated to the level of antioxidant potential in patients' plasma, the status of oxidative stress in the blood may indicate the extent of organ damage in clinical situations.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

doi

10.1007/s12185-016-2112-1

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

295-308

issue

3

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-016-2112-1

journal_volume

105

pub_type

杂志文章,随机对照试验

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