Successful cord blood transplantation for mycosis fungoides.

Abstract:

:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.

journal_name

Int J Hematol

authors

Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M

doi

10.1007/s12185-008-0190-4

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

596-598

issue

5

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-008-0190-4

journal_volume

88

pub_type

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