Abstract:
:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga Mdoi
10.1007/s12185-008-0190-4subject
Has Abstractpub_date
2008-12-01 00:00:00pages
596-598issue
5eissn
0925-5710issn
1865-3774pii
10.1007/s12185-008-0190-4journal_volume
88pub_type
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