Successful cord blood transplantation for mycosis fungoides.


:A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.


Int J Hematol


Fukushima T,Horio K,Matsuo E,Imanishi D,Yamasaki R,Tsushima H,Imaizumi Y,Ohshima K,Hata T,Yoshida S,Miyazaki Y,Tomonaga M




Has Abstract


2008-12-01 00:00:00














  • Myelodysplastic syndrome associated with erythrophagocytosis by blasts and myeloid cells.

    abstract::A 63-year-old man with refractory anemia with excess of blasts in transformation exhibited erythroid hyperplasia, dyserythropoiesis, a del(20q) abnormality, susceptibility to bacterial infections, and a relatively short survival. Phagocytosis of erythrocytes by blast cells was observed. Erythrophagocytosis was also se...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Kuyama J,Fushino M,Take H,Kanayama Y

    更新日期:1995-12-01 00:00:00

  • Promoter hypermethylation of the DNA-repair gene O6-methylguanine-DNA methyltransferase and p53 mutation in diffuse large B-cell lymphoma.

    abstract::The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene is a favorable progno...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Hiraga J,Kinoshita T,Ohno T,Mori N,Ohashi H,Fukami S,Noda A,Ichikawa A,Naoe T

    更新日期:2006-10-01 00:00:00

  • Primary mediastinal large B-cell lymphoma in Japanese children and adolescents.

    abstract::This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Osumi T,Tanaka F,Mori T,Fukano R,Tsurusawa M,Oshima K,Nakazawa A,Kobayashi R

    更新日期:2017-04-01 00:00:00

  • Monosomies 7p and 12p and FLT3 internal tandem duplication: possible markers for diagnosis of T/myeloid biphenotypic acute leukemia and its clonal evolution.

    abstract::Biphenotypic acute leukemia co-expressing T-lymphoid and myeloid markers is rare, accounting for less than 1% of acute leukemias. However, several clinical characteristics including male predominance, frequent lymphadenopathy and unfavorable outcome have been identified. Recurrence of monosomies 7p and/or 12p in T/mye...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Matsumoto Y,Taki T,Fujimoto Y,Taniguchi K,Shimizu D,Shimura K,Uchiyama H,Kuroda J,Nomura K,Inaba T,Shimazaki C,Horiike S,Taniwaki M

    更新日期:2009-04-01 00:00:00

  • Feasibility and obstacles in home chemotherapy for malignant lymphoma.

    abstract::Home care has become a treatment option for cancer patients; however, medical practice at patients' homes has been expected mainly for terminal care in Japan. Most physicians believe that it is difficult to treat patients with hematologic malignancy at home because they frequently develop complications requiring urgen...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kodama Y,Kami M,Yuji K,Kuboya M,Komatsu T

    更新日期:2007-12-01 00:00:00

  • Successful bone marrow transplantation for severe aplastic anemia in a patient with persistent human parvovirus B19 infection.

    abstract::Persistent infection with human parvovirus B19 (B19) is primarily associated with chronic bone marrow failure in immunocompromised patients, but occasionally this organism may also affect immunocompetent hosts. B19 is also suggested as a causative agent of organ failure during bone marrow transplantation (BMT). We her...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Goto H,Ishida A,Fujii H,Kuroki F,Takahashi H,Ikuta K,Kai S,Yokota S

    更新日期:2004-05-01 00:00:00

  • Importance of CD4+ helper T-cells in antitumor immunity.

    abstract::CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding o...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Shiku H

    更新日期:2003-06-01 00:00:00

  • E148Q/M694I mutation in 3 Japanese patients with familial Mediterranean fever.

    abstract::We describe 3 unrelated Japanese patients with familial Mediterranean fever (FMF) due to a compound heterozygous E148Q/M694I mutation in the MEFV gene. The first patient is a 38-year-old man who also has chronic myelogenous leukemia (CML). Because genomic DNA analysis of the patient's nail revealed the E148Q/M694I mut...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kotone-Miyahara Y,Takaori-Kondo A,Fukunaga K,Goto M,Hayashino Y,Miki M,Takayama H,Sasada M,Uchiyama T

    更新日期:2004-04-01 00:00:00

  • Allele frequencies and molecular genotyping of the ABO blood group system in a Kuwaiti population.

    abstract::The phenotypic distributions of observed numbers of ABO blood groups in a Kuwaiti sample population of 18,558 subjects are 4962 (26.7%) with A, 4,462 (24.1%) with B, 858 (4.6%) with AB, and 8,276 (44.6%) with 0. The calculated gene frequencies are 0.6678 for ABO*O, 0.1768 for ABO*A, and 0.1554 for ABO*B. Molecular gen...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Al-Bustan S,El-Zawahri M,Al-Azmi D,Al-Bashir AA

    更新日期:2002-02-01 00:00:00

  • Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood.

    abstract::We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, t...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kitamura K,Nishiyama T,Ishiyama K,Miyawaki S,Miyazaki K,Suzuki K,Masaie H,Okada M,Ogawa H,Imai K,Kiyoi H,Naoe T,Yokoyama Y,Chiba S,Hata T,Miyazaki Y,Hatta Y,Takeuchi J,Nannya Y,Kurokawa M,Ueda Y,Koga D,Sugiyam

    更新日期:2016-01-01 00:00:00

  • A prospective randomized trial of KRN8602 and cytosine arabinoside vs. daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. The KRN8602 Leukemia Study Group.

    abstract::A prospective randomized study was conducted to compare the efficacy and toxicity of two anthracyclines for the treatment of patients with acute myelogenous leukemia (AML). Fifty-eight patients were randomized and received induction therapy consisting of cytosine arabinoside (AraC) 100 mg/m2/day for 7 days combined wi...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Takemoto Y,Sampi K,Kuraishi Y,Okabe K,Tamura K,Mizoguchi H,Saito H,Masaoka T,Ogawa M

    更新日期:1999-07-01 00:00:00

  • Phase 2 trial of daily, oral epigallocatechin gallate in patients with light-chain amyloidosis.

    abstract::Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...

    journal_title:International journal of hematology

    pub_type: 杂志文章,随机对照试验


    authors: Meshitsuka S,Shingaki S,Hotta M,Goto M,Kobayashi M,Ukawa Y,Sagesaka YM,Wada Y,Nojima M,Suzuki K

    更新日期:2017-03-01 00:00:00

  • APOBEC family proteins: novel antiviral innate immunity.

    abstract::APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Takaori-Kondo A

    更新日期:2006-04-01 00:00:00

  • CD34+ progenitor cell transplantation from two HLA-mismatched healthy fathers to two infants with severe aplastic anemia.

    abstract::Pluripotent stem cells of hematopoiesis are included among CD34+ cells in the blood and bone marrow. After granulocyte-colony stimulating factor (G-CSF) mobilization, 1-2% of the mononuclear cells in the blood are CD34+ cells, which can be obtained by leukapheresis. We performed CD34+ progenitor cell transplantation i...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yasui M,Park YD,Okamura T,Chayama K,Yoshimoto T,Inoue M,Yagi K,Kawa K

    更新日期:1998-01-01 00:00:00

  • Stable response after administration of stem cell factor combined with granulocyte colony-stimulating factor in aplastic anemia.

    abstract::We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

    更新日期:2006-06-01 00:00:00

  • Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma.

    abstract::Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six p...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yoo C,Yoon DH,Kim JE,Jo J,Park SJ,Yoon SK,Ahn Y,Kim S,Huh J,Lee DH,Suh C

    更新日期:2013-02-01 00:00:00

  • Dilated cardiomyopathy during the course of hemolytic uremic syndrome.

    abstract::A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

    更新日期:2007-11-01 00:00:00

  • IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.

    abstract::Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Hosgood HD 3rd,Au WY,Kim HN,Liu J,Hu W,Tse J,Song B,Wong KF,Lee JJ,Chanock SJ,Siu LP,Purdue MP,Shin MH,Yu J,Liang R,Kim HJ,Rothman N,Lan Q

    更新日期:2013-06-01 00:00:00

  • Prognostic value of cytogenetic findings in adults with acute myeloid leukemia.

    abstract::The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Mrózek K,Heinonen K,Bloomfield CD

    更新日期:2000-10-01 00:00:00

  • Safety, therapeutic effectiveness, and cost of parenteral iron therapy.

    abstract::Patients have to discontinue the use of oral iron therapy due to the development of side effects and lack of long-term adherence to medication for iron deficiency anemia. This study aimed to evaluate the therapeutic effectiveness, safety, and cost of intravenous iron sucrose therapy. The computerized database and medi...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Asma S,Boga C,Ozdogu H

    更新日期:2009-07-01 00:00:00

  • Establishment of novel cell lines derived from two patients with chronic myelogenous leukemia in blast crisis; IMS-BC1 and IMS-BC2 which exhibit markedly different sensitivity to apoptosis.

    abstract::We established two novel cell lines, designated as IMS-BC1 and IMS-BC2, from two patients with chronic myelogenous leukemia in blast crisis. The two cell lines were positive for CD13 and CD33 and negative for CD34 and HLA-DR by surface marker analysis. IMS-BC1 had four Philadelphia (Ph1) chromosomes and a breakpoint w...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Nagamura F,Nagamura-Inoue T,Tojo A,Minamihisamatsu M,Tanabe T,Zaike Y,Tani K,Saisho H,Asano S

    更新日期:1998-04-01 00:00:00

  • Stem and progenitor cells in human umbilical cord blood.

    abstract::Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly i...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Lee MW,Jang IK,Yoo KH,Sung KW,Koo HH

    更新日期:2010-07-01 00:00:00

  • Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome, 2015 version.

    abstract::TAFRO syndrome is a systemic inflammatory disorder characterized by thrombocytopenia, anasarca including pleural effusion and ascites, fever, renal insufficiency, and organomegaly including hepatosplenomegaly and lymphadenopathy. Its onset may be acute or sub-acute, but its etiology is undetermined. Although several c...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Masaki Y,Kawabata H,Takai K,Kojima M,Tsukamoto N,Ishigaki Y,Kurose N,Ide M,Murakami J,Nara K,Yamamoto H,Ozawa Y,Takahashi H,Miura K,Miyauchi T,Yoshida S,Momoi A,Awano N,Ikushima S,Ohta Y,Furuta N,Fujimoto S,Ka

    更新日期:2016-06-01 00:00:00

  • Clinical and hematological characteristics of uncommon beta-globin variants in Thailand.

    abstract::Hemoglobin (Hb) E is the commonest beta-globin variant in Thailand. Other uncommon variants have been rarely reported. We performed direct DNA sequencing of the entire beta-globin gene in cases showing unidentified bands by isolectric focusing electrophoresis or high-performance liquid chromatography. Six different be...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Uaprasert N,Rojnuckarin P,Settapiboon R,Amornsiriwat S,Sutcharitchan P

    更新日期:2009-06-01 00:00:00

  • Unique association of Waldenström macroglobulinemia with optic neuritis and monoclonal T cell expansion.

    abstract::Waldenström macroglobulinemia is a lymphoplasmacytic lymphoma characterized by production of the immunoglobulin M (IgM) monoclonal protein. Commonly involved sites are the bone marrow, lymph nodes, and spleen. Lymphoplasmacytic infiltration of the central nervous system (CNS), in contrast, is referred to as Bing-Neel ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Morita K,Yoshimi A,Masuda A,Ichikawa M,Yatomi Y,Kurokawa M

    更新日期:2013-08-01 00:00:00

  • Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation for multiple myeloma.

    abstract::We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

    更新日期:2015-12-01 00:00:00

  • Overview of guidelines on iron chelation therapy in patients with myelodysplastic syndromes and transfusional iron overload.

    abstract::Between 2002 and 2008, a number of consensus statements and guidelines were developed by various groups around the world to educate healthcare professionals on the treatment of myelodysplastic syndromes (MDS), including the management of transfusional iron overload with iron chelation therapy. Guidelines have been dev...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Gattermann N

    更新日期:2008-07-01 00:00:00

  • Recent advance in molecular iron metabolism: translational disorders of ferritin.

    abstract::Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Kato J,Niitsu Y

    更新日期:2002-10-01 00:00:00

  • Early electrocardiographic evaluation of atrial fibrillation risk in beta-thalassemia major patients.

    abstract::Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Russo V,Rago A,Pannone B,Di Meo F,Papa AA,Mayer MC,Spasiano A,Russo MG,Golino P,Calabrò R,Nigro G

    更新日期:2011-04-01 00:00:00

  • Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors.

    abstract::Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CL...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Xu W,Cao X,Miao KR,Qiao C,Wu YJ,Liu Q,Fan L,Li JY

    更新日期:2009-09-01 00:00:00