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Successful treatment of anti-erythropoietin antibody-mediated pure red cell aplasia with low-dose prednisolone.

Abstract：

:The standard therapy for anti-erythropoietin (EPO) antibody-mediated pure red cell aplasia (PRCA) is cyclosporine (CyA) or prednisolone (PSL) 0.5-1.0 mg/kg. However, many patients with severe chronic kidney disease (CKD) and chronic heart failure cannot tolerate such an immunosuppressive regimen. An 86-year-old man with anemia related to CKD and chronic heart failure, who had received recombinant human erythropoietin subcutaneously, developed anti-EPO antibody-mediated PRCA. The patient was treated with CyA followed by PSL (1.0 mg/kg); however, he was unable to tolerate this drug regimen. The PSL dose was reduced to 0.2 mg/kg. Surprisingly, his reticulocyte count increased 3 months later, and RBC transfusion was no longer required. Low-dose PSL is a treatment option for patients with anti-EPO antibody-mediated PRCA who cannot tolerate CyA and PSL (0.5-1.0 mg/kg).

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Aoki K,Ono Y,Tabata S,Matsushita A,Ishikawa T

doi

10.1007/s12185-013-1258-3

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

272-4

issue

2

eissn

0925-5710

issn

1865-3774

journal_volume

97

pub_type

杂志文章

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