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Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias.

Abstract：

:MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers, including in malignant lymphomas (MLs). Detailed genome-wide miRNA expression analysis has been performed in various ML subtypes, and these analyses have led to the discovery of subtype-specific miRNA alterations. Actually, in B-cell lymphomas, several miRNAs have been used as prognostic markers, and their targets are for new agents for ML therapy. Successful studies for delineating miRNA functions in B-cell lymphomas lead us to hypothesize that miRNA dysregulation may also be deeply associated with the pathogenesis of T-cell lymphomas. Indeed, studies for delineating essential miRNAs have been conduced against comparatively well-defined T-cell lymphoma entities. In this review, we describe several key miRNAs and their targets in distinct T-cell lymphoma subsets and their roles in their pathogenesis, studies of which will lead to new therapeutic strategies against T-cell lymphomas.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Ikeda S,Tagawa H

doi

10.1007/s12185-014-1535-9

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

542-52

issue

5

eissn

0925-5710

issn

1865-3774

journal_volume

99

pub_type

杂志文章,评审

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