Biology and clinical application of CAR T cells for B cell malignancies.

abstract：:Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia, classified into primary and secondary types. Secondary CAD accompanies infection or malignant disease, most often lymphoma, whereas primary CAD frequently represents a lymphoproliferative bone marrow disorder characterized by clonal expansion of B ce...

journal_title：International journal of hematology

authors： Tanaka H,Hashimoto S,Sugita Y,Sakai S,Takeda Y,Abe D,Takagi T,Nakaseko C

更新日期：2012-10-01 00:00:00

abstract：:Although previous studies have documented a variety of electrocardiogram abnormalities in beta-thalassemia major (β-TM), little is known about P-wave dispersion (PD), an independent risk factor for development of atrial fibrillation. The aim of our study was to evaluate PD in β-TM patients with conserved systolic and ...

journal_title：International journal of hematology

authors： Russo V,Rago A,Pannone B,Di Meo F,Papa AA,Mayer MC,Spasiano A,Russo MG,Golino P,Calabrò R,Nigro G

更新日期：2011-04-01 00:00:00

abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

journal_title：International journal of hematology

authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

更新日期：2014-02-01 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the abnormal accumulation of alveolar surfactant protein in alveolar spaces. We report herein a rare case of myelodysplastic syndrome (MDS-RAEB) complicated by severe PAP, and successful allogeneic bone marrow transplantation (BMT) for both disor...

journal_title：International journal of hematology

authors： Tabata S,Shimoji S,Murase K,Takiuchi Y,Inoue D,Kimura T,Nagai Y,Mori M,Togami K,Kurata M,Ito K,Hashimoto H,Matushita A,Nagai K,Takahashi T

更新日期：2009-10-01 00:00:00

abstract：:Gene-marking studies were the first approved clinical protocols introducing exogenous genetic material into human cells. Such studies were never intended to provide direct therapeutic benefit. Instead, they were expected to provide information about normal cell biology and disease pathogenesis that could not be obtain...

journal_title：International journal of hematology

authors： Bollard CM,Heslop HE,Brenner MK

更新日期：2001-01-01 00:00:00

abstract：:A 37-year-old male from Kagoshima Prefecture was admitted with adult T-cell leukemia (ATL). Monoclonal integration of HTLV-1 proviral DNA was found, but the integration site was different from that of terminal deoxynucleotidyltransferase (TdT)-positive MT-1 cells (an ATL cell line). The ATL cells expressed enzymatical...

journal_title：International journal of hematology

authors： Oiwa K,Horibe K,Koiwai O,Kaneda T,Nakaide Y,Tamori S,Kodaka T,Uchiyama T

更新日期：1991-02-01 00:00:00

abstract：:Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...

journal_title：International journal of hematology

authors： Ureshino H,Koarada S,Kamachi K,Yoshimura M,Yokoo M,Kubota Y,Ando T,Ichinohe T,Morio T,Kimura S

更新日期：2020-06-01 00:00:00

abstract：:We evaluated the efficacy and toxicity of a new salvage regimen, consisting of rituximab (375 mg/m(2), day 1), ifosfamide (1500 mg/m(2) on days 3-7), etoposide (150 mg/m(2), days 3-5), cytarabine (100 mg/m(2), days 3-5) and dexamethasone (40 mg/body, days 3-5) (R-IVAD) for relapsed or refractory aggressive B-cell lymp...

journal_title：International journal of hematology

authors： Miura K,Takei K,Kobayashi S,Kiso S,Hirabayashi Y,Hojo A,Kodaira H,Yagi M,Kurita D,Kobayashi Y,Tanaka T,Iriyama N,Hatta Y,Kura Y,Yamazaki T,Sawada U,Takeuchi J

更新日期：2011-07-01 00:00:00

abstract：:Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

journal_title：International journal of hematology

authors： Kato J,Niitsu Y

更新日期：2002-10-01 00:00:00

abstract：:A 71-year-old petite Japanese woman was diagnosed with IgG λ-type multiple myeloma with acute kidney injury, severe anemia, and a pathological rib fracture. Emergent hemodialysis was initiated combined with chemotherapy including bortezomib, lenalidomide, and pomalidomide, but myeloma had become refractory due to the ...

journal_title：International journal of hematology

authors： Mizuno S,Kitayama C,Yamaguchi K,Sanada S,Sato T

更新日期：2020-12-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...

journal_title：International journal of hematology

authors： Yanada M,Naoe T

更新日期：2012-08-01 00:00:00

abstract：:The management of elderly patients with acute myeloid leukemia (AML) and a poor performance status is challenging. An 89-year-old man with AML secondary to myelodysplastic syndrome (MDS) and a poor performance status (4) underwent treatment with methylprednisolone (mPSL) (125 mg/body), which resulted in a remarkable r...

journal_title：International journal of hematology

authors： Suzuki K,Ohishi K,Sekine T,Masuya M,Katayama N

更新日期：2007-05-01 00:00:00

abstract：:Imatinib mesylate and rituximab are molecularly targeted drugs against the BCR-ABL fusion protein and the CD20 antigen, respectively. Although these drugs have excellent anticancer effects, a major concern is drug resistance. We have investigated the case of a patient with Philadelphia chromosome-positive and CD20+ ac...

journal_title：International journal of hematology

authors： Hato T,Yamanouchi J,Tamura T,Hojo N,Niiya Y,Kohno M,Bando S,Yakushijin Y,Takada K,Sakai I,Yasukawa M,Fujita S

更新日期：2004-07-01 00:00:00

abstract：:In this study, tetramethylpyrazine (TMPZ) was effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 40 and 80 microg/g. In addition, intravenous injection of TMPZ (10 microg/g) significantly prolonged the bleeding time by approximately 1....

journal_title：International journal of hematology

authors： Sheu JR,Hsiao G,Lee YM,Yen MH

更新日期：2001-04-01 00:00:00

abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

journal_title：International journal of hematology

authors： Nakao S,Feng X,Sugimori C

更新日期：2005-10-01 00:00:00

abstract：:Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

journal_title：International journal of hematology

authors： de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

更新日期：2011-02-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00

abstract：:We previously reported that the use of polymerase chain reaction (PCR) in detecting cytomegalovirus (CMV) DNA in serum (sPCR) enables the detection of CMV viremia, which has not been possible with other methods. In this study, the clinical usefulness of sPCR was investigated by comparison with the results of three oth...

journal_title：International journal of hematology

authors： Matsunaga T,Sakamaki S,Ishigaki S,Kohda K,Takeda M,Katoh J,Kuroda H,Hirayama Y,Kusakabe T,Akiyama T,Kuga T,Niitsu Y,Masaoka T,Sagawa T,Matsumoto Y

更新日期：1999-02-01 00:00:00

abstract：:Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...

journal_title：International journal of hematology

authors： Kawada H,Ito T,Pharr PN,Spyropoulos DD,Watson DK,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：:We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...

journal_title：International journal of hematology

authors： Nakano T

更新日期：1996-12-01 00:00:00

abstract：:We report a case of successful umbilical cord blood transplantation (CBT) for Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) in a 6-year-old girl. The patient had hemophagocytic syndrome with excessive circulating levels of EBV DNA that was refractory to immunochemotherapy. Multiple hepatospleni...

journal_title：International journal of hematology

authors： Toubo T,Suga N,Ohga S,Nomura A,Onoe Y,Takada H,Hara T

更新日期：2004-12-01 00:00:00

abstract：:Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...

journal_title：International journal of hematology

authors： Kamikubo KH,Ogata K,An E,Dan K

更新日期：2000-04-01 00:00:00

abstract：:miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reporte...

journal_title：International journal of hematology

authors： Kotaki R,Higuchi H,Ogiya D,Katahira Y,Kurosaki N,Yukihira N,Ogata J,Yamamoto H,Mohamad Alba S,Azhim A,Kitajima T,Inoue S,Morishita K,Ono K,Koyama-Nasu R,Kotani A

更新日期：2017-12-01 00:00:00

abstract：:A 38-year-old Japanese man with myelodysplastic syndrome (MDS), whose bone marrow smears demonstrated hypercellularity, was treated with oral cyclosporin A (CsA) therapy. During the course of this therapy, the numbers of peripheral blood and bone marrow blasts increased and the level of serum lactate dehydrogenase inc...

journal_title：International journal of hematology

authors： Itoh M,Yago K,Shimada H,Tohyama K

更新日期：2002-04-01 00:00:00

abstract：:Home care has become a treatment option for cancer patients; however, medical practice at patients' homes has been expected mainly for terminal care in Japan. Most physicians believe that it is difficult to treat patients with hematologic malignancy at home because they frequently develop complications requiring urgen...

journal_title：International journal of hematology

authors： Kodama Y,Kami M,Yuji K,Kuboya M,Komatsu T

更新日期：2007-12-01 00:00:00

abstract：:The prognosis of therapy-related myelodysplastic syndrome and acute leukemia (t-MDS/AL) remains poor. We retrospectively analyzed the data of 47 patients (31 AL and 16 MDS) who were treated at our institute. Thirty-three patients received disease-adapted chemotherapy, with a response rate of 73%, while 14 received no ...

journal_title：International journal of hematology

authors： Yokoyama H,Mori S,Kobayashi Y,Kurosawa S,Saito B,Fuji S,Maruyama D,Azuma T,Kim SW,Watanabe T,Tanosaki R,Tobinai K,Takaue Y,Fukuda T

更新日期：2010-09-01 00:00:00

abstract：:We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...

journal_title：International journal of hematology

authors： Takezawa Y,Terasawa F,Matsuda K,Sugano M,Tanaka A,Fujiwara M,Kainuma K,Okumura N

更新日期：2012-07-01 00:00:00

abstract：:We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

journal_title：International journal of hematology

authors： Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

更新日期：2006-06-01 00:00:00

abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

journal_title：International journal of hematology

authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

更新日期：2011-04-01 00:00:00

abstract：:Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...

journal_title：International journal of hematology

authors： Braggio E,Maiolino A,Gouveia ME,Magalhães R,Souto Filho JT,Garnica M,Nucci M,Renault IZ

更新日期：2010-01-01 00:00:00