Abstract:
:Multicenter, prospective study was conducted to evaluate the efficacy of biweekly romiplostim in maintaining platelet ≥ 30 × 10(9)/L for at least 4 weeks. Treatment was started with a weekly injection (1 mcg/kg), and the dose was escalated until a titrated dose was achieved that maintained a platelet 50-200 × 10(9)/L for four consecutive weeks. Patients were scheduled to a biweekly schedule, and returned to a weekly schedule if platelets fell to <30 × 10(9)/L. Eighteen patients were enrolled (median platelet, 14 × 10(9)/L). After the first weekly schedule, ten of eighteen (55.6 %) attained a median titrated dose of 3 mcg/kg and proceeded to the first biweekly schedule. However, all failed to maintain a platelet ≥ 30 × 10(9)/L for at least 4 weeks, and returned to a second weekly schedule, where eight of the ten achieved a titrated dose (median, 5 mcg/kg) and moved to a second schedule of biweekly romiplostim. Three of the eight (37.5 %) showed platelet ≥ 30 × 10(9)/L for 4, 8, and 10 weeks, but all eight patients eventually experienced a drop in platelets. Lengthening the dose interval of romiplostim to greater than a week is not feasible to maintain stable platelet count.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Park S,Yoon SS,Lee JH,Park JS,Jang JH,Lee JWdoi
10.1007/s12185-015-1889-7subject
Has Abstractpub_date
2016-01-01 00:00:00pages
44-52issue
1eissn
0925-5710issn
1865-3774pii
10.1007/s12185-015-1889-7journal_volume
103pub_type
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