Abstract:
:Mesenchymal stromal cells may reverse acute inflammatory disorders. The placenta is important in feto-maternal tolerance. We have used placenta-derived decidua stromal cells (DSCs) to treat graft-versus-host disease and found an immunomodulatory and anti-inflammatory effect. We here report the use of DSCs in two patients with radiculomyelopathy. The first patient was a 73-year old man treated with parotidectomy and irradiation for lymphoma of the neck. Following a Yersinia infection, he developed a radiculomyelopathy in C3/C4 and could not elevate his arms. The second patient was a 34-year old woman who was admitted 8 months after allogeneic hematopoietic stem cell transplantation due to hemolysis, impaired sensorium below arcus, and difficulty in ambulation. Following intravenous infusion of DSCs (1 × 106/kg/infusion), the first patient could elevate his arms to the facial level. He experienced recurrent paralysis after 6 months, and the efficacy of four additional DSC infusions, at subsequent occasions, were limited and transient. The second patient was treated with two doses of DSCs (1 × 106/kg/infusion). After cell infusion, she was able to stand on one leg, sensation in the belly normalized, and she was discharged. These two cases suggest that DSCs may be useful in the treatment of neuroinflammatory disorders.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Sadeghi B,Ersmark B,Moretti G,Mattsson J,Ringdén Odoi
10.1007/s12185-019-02804-wsubject
Has Abstractpub_date
2020-04-01 00:00:00pages
591-594issue
4eissn
0925-5710issn
1865-3774pii
10.1007/s12185-019-02804-wjournal_volume
111pub_type
杂志文章abstract::Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodiffe...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982545
更新日期:2001-07-01 00:00:00
abstract::To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2446-y
更新日期:2018-08-01 00:00:00
abstract::A 67-year-old female was referred to our hospital with a sternal fracture in March 2008. She received a diagnosis of multiple myeloma (MM) BJP-κ type (ISS stage III). G-banding karyotype revealed 46, XX, t(11;22)(q23.3;q11.2) (Hubacek, Gene 592:193-9, 2016), which was later confirmed to be congenital. After repeated r...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02603-3
更新日期:2019-06-01 00:00:00
abstract::The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0590-0
更新日期:2010-06-01 00:00:00
abstract::miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reporte...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-017-2314-1
更新日期:2017-12-01 00:00:00
abstract::Acute myeloid leukemia (AML) is predominantly a disease of older adults, with a median age at diagnosis of over 65 years. AML in older adults differs biologically and clinically from that in younger ones, and is characterized by stronger intrinsic resistance and lower tolerance to chemotherapy. The effects of age on b...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-012-1137-3
更新日期:2012-08-01 00:00:00
abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0126-z
更新日期:2008-09-01 00:00:00
abstract::Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping ana...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0929-1
更新日期:2011-10-01 00:00:00
abstract::Neurological complications in thrombotic thrombocytopenic purpura (TTP) are associated with poor prognosis and/or permanent damage. We report a young woman in whom the diagnosis of TTP was difficult because cardinal manifestations were absent at presentation. The patient relapsed, showing severe and dramatic neurologi...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::A series of expression microarray analyses of chronic myeloid leukemia (CML) by means of complementary DNA microarray representing a set of 1024 human genes were initiated to evaluate the role of expression microarray analysis in CML and to identify CML-associated genes. Among the target genes, 388 differentially expr...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982130
更新日期:2002-05-01 00:00:00
abstract::Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) comprises a group of heterogeneous lymphomas that do not fit any other identified PTCL-subgroup and show poor prognosis. To clarify clinical aspects of Japanese PTCL-NOS patients, the Hokkaido Hematology Study Group conducted a multicenter retrospective ana...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s12185-013-1383-z
更新日期:2013-08-01 00:00:00
abstract::We report an infant with autoimmune neutropenia (AIN), idiopathic thrombocytopenia (ITP), and IgG2/IgA deficiency. The patient was referred to our hospital at 5 months of age because of epistaxis and generalized petechiae. Physical examination revealed moderate hepatosplenomegaly. A complete blood count revealed a pla...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lym...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1256-x
更新日期:2013-02-01 00:00:00
abstract::Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is as...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2124-x
更新日期:2017-01-01 00:00:00
abstract::Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-016-2110-3
更新日期:2017-02-01 00:00:00
abstract::Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-01 00:00:00
abstract::Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0757-8
更新日期:2011-02-01 00:00:00
abstract::Noonan syndrome (NS) is an autosomal-dominant disease characterized by distinctive facial features, webbed neck, cardiac anomalies, short stature and cryptorchidism. NS exhibits phenotypic overlap with Costello syndrome and cardio-facio-cutaneous (CFC) syndrome. Germline mutations of genes encoding proteins in the RAS...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-012-1239-y
更新日期:2013-01-01 00:00:00
abstract::Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Philadelphia (Ph) chromosome as a result of t (9; 22) (q34; q11) is observed in more than 90% of chromic myeloid leukemia (CML) patients. Cases in which the typical Ph chromosome is not visible at the karyotype level comprise 5-10% of CML patients. CML cases with fusion transcripts such as e13a3 in which ABL exon 3 ra...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0368-4
更新日期:2009-09-01 00:00:00
abstract::Severe fungal infections remain a significant cause of morbidity and mortality in neutropenic patients undergoing dose-intensive chemotherapy for malignant diseases. Chronic disseminated candidiasis (CDC) is a life-threatening complication in neutropenic patients because of the lack of responsive hematopoietic precurs...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.e0315
更新日期:2004-04-01 00:00:00
abstract::We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1100-3
更新日期:2012-07-01 00:00:00
abstract::Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1211-x
更新日期:2012-12-01 00:00:00
abstract::Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0966-9
更新日期:2011-12-01 00:00:00
abstract::Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02834-9
更新日期:2020-06-01 00:00:00
abstract::Kinetic resistance is assumed to be one of the main mechanisms of drug resistance in acute myeloid leukemia (AML), but the relationship between cell cycle status at diagnosis and achievement of complete remission (CR) is controversial. Based on the possibility that the cell cycle data after starting induction chemothe...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract::Initial treatment with androgen (metenolone acetate) alone for 19 weeks had no effect in a 45-year-old Japanese female with refractory anemia (RA). The patient achieved trilineage hematologic recovery after addition of recombinant human granulocyte colony-stimulating factor (G-CSF) and recombinant human erythropoietin...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(96)00530-0
更新日期:1996-12-01 00:00:00
abstract::Hematologic malignancies have historically been characterized by morphologic, immunophenotypic, molecular, and genetic features. However, morphologically identical tumors can have clearly distinct clinical outcomes, suggesting underlying biological heterogeneity. Recent advances in microarray technology have helped th...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/ijh97.04133
更新日期:2004-12-01 00:00:00
abstract::The role of reactive oxygen species (ROS) in the cytotoxicity of N-(4-hydroxyphenyl)retinamide (4-HPR) was studied with use of the B-precursor lymphoblastic leukemia cell line YCUB-2. The increase in intracellular ROS measured with 2'-7'-dichlorodihydrofluorescein diacetate after 3 hours' incubation was 3.7-fold with ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983798
更新日期:2003-10-01 00:00:00
abstract::The distinction between RAEB, RAEB-T and AML M6a is difficult when erythroblasts in the bone marrow (BM) exceed 50%. We analyzed 19 children (2 RAEB, 13 RAEB-T and 4 AML M6a) enrolled in a prospective pathological central review in Japan and divided them into two groups according to the myeloblasts percentage among no...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1007/s12185-008-0183-3
更新日期:2008-12-01 00:00:00