当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA.

Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA.

Abstract：

:Severe congenital neutropenia (SCN) is characterized by a maturation arrest of myeloid progenitor cells at the stage of promyelocytes in bone marrow and low levels of mature neutrophils in peripheral blood. To date, little is known regarding the underlying pathomechanism of SCN. A defective response of neutrophil precursors to granulocyte colony-stimulating factor (G-CSF) is a suggested mechanism. In the last few years, we and others described point mutations in the cytoplasmic domain of the G-CSF receptor (G-CSFR) mRNA in a subgroup of SCN patients. In one allele of the G-CSFR gene, a C to T substitution resulted in a change from a glutamine codon to a stop codon. The expected G-CSFR proteins were truncated by 83 to 98 amino acids. In this study, we show that the Lyn and Syk kinases are associated with the G-CSFR in neutrophils from SCN patients with point mutations in the cytoplasmic domain of the G-CSFR mRNA. These findings provide additional proof of the expression of normal G-CSFRs in these patients, because the possible Syk binding motif is located between amino acid 727 and 747 in the G-CSFR.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Kasper B,Tidow N,Welte K

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

241-7

issue

4

eissn

0925-5710

issn

1865-3774

journal_volume

70

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF HEMATOLOGY文献大全
  • The effect of phlebotomy on serum erythropoietin levels in normal healthy subjects.

    abstract：:We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

    更新日期：1992-04-01 00:00:00

  • Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: a large retrospective study.

    abstract：:Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...

    journal_title：International journal of hematology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s12185-018-2520-5

    authors： Piccin A,Tagnin M,Vecchiato C,Al-Khaffaf A,Beqiri L,Kaiser C,Agreiter I,Negri G,Kob M,Di Pierro A,Vittadello F,Mazzoleni G,Eisendle K,Fontanella F

    更新日期：2018-12-01 00:00:00

  • A presentation, treatment, and survival analysis of primary cardiac lymphoma cases reported from 2009 to 2019.

    abstract：:The heart is a rare primary site of lymphoma, and cardiac involvement is thought to bring a poorer prognosis. A framework of known clinical presentations, diagnostic features, disease complications, treatments, and outcomes to improve prognostication was constructed by a systematic review in 2011. However, some aspect...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-020-02881-2

    authors： Chen H,Qian S,Shi P,Liu L,Yang F

    更新日期：2020-07-01 00:00:00

  • Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study.

    abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-011-0825-8

    authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

    更新日期：2011-04-01 00:00:00

  • MALT lymphoma of the thymus with Sjögren's syndrome: biphasic changes in serological abnormalities over a 4-year period following thymectomy.

    abstract：:Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0324-3

    authors： Sakamoto T,Yamashita K,Mizumoto C,Ueda M,Takeoka T,Hishita T,Hada S,Ohno T

    更新日期：2009-06-01 00:00:00

  • Serial morphologic observation of bone marrow in aplastic anemia in children.

    abstract：:Recent reports of myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) developing after treatment with immunosuppressants and granulocyte colony-stimulating factor (G-CSF) has raised the question of whether previously unrecognized myelodysplastic features had been present or whether actual transformation had oc...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1532/ijh97.04178

    authors： Bessho F,Imashuku S,Hibi S,Tsuchida M,Nakahata T,Miyazaki S,Kojima S,Tsukimoto I,Hamajima N,Pediatric AA Follow-up Study Group in Japan.

    更新日期：2005-06-01 00:00:00

  • APOBEC family proteins: novel antiviral innate immunity.

    abstract：:APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/IJH97.05187

    authors： Takaori-Kondo A

    更新日期：2006-04-01 00:00:00

  • Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.

    abstract：:Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1244-1

    authors： Chen DB,Song QJ,Chen YX,Chen YH,Shen DH

    更新日期：2013-01-01 00:00:00

  • Serum thymidine kinase 1 concentration in Chinese patients with chronic lymphocytic leukemia and its correlation with other prognostic factors.

    abstract：:Chronic lymphocytic leukemia (CLL) shows a remarkable heterogeneity, with some patients having an almost normal lifespan, others surviving only several months after diagnosis despite intensive therapy. The aim of this study was to investigate the serum thymidine kinase 1 (TK1) concentration in Chinese patients with CL...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0380-8

    authors： Xu W,Cao X,Miao KR,Qiao C,Wu YJ,Liu Q,Fan L,Li JY

    更新日期：2009-09-01 00:00:00

  • Neutropenic enterocolitis in adult leukemias.

    abstract：:Neutropenic enterocolitis is a frequent autopsy finding in adult patients with acute leukemias. The predisposing factors other than neutropenia are not clear. There are also contradictions about treatment. Therefore, this entity still presents a diagnostic and therapeutic dilemma for clinicians. This retrospective stu...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Büyükaşik Y,Ozcebe OI,Haznedaroğlu IC,Sayinalp N,Soylu AR,Ozdemir O,Dündar S

    更新日期：1997-07-01 00:00:00

  • Iron overload patients with unknown etiology from national survey in Japan.

    abstract：:Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-016-2141-9

    authors： Ikuta K,Hatayama M,Addo L,Toki Y,Sasaki K,Tatsumi Y,Hattori A,Kato A,Kato K,Hayashi H,Suzuki T,Kobune M,Tsutsui M,Gotoh A,Aota Y,Matsuura M,Hamada Y,Tokuda T,Komatsu N,Kohgo Y

    更新日期：2017-03-01 00:00:00

  • Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia.

    abstract：:TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Suc...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-018-2518-z

    authors： Tan TK,Zhang C,Sanda T

    更新日期：2019-01-01 00:00:00

  • CD64 surface expression on neutrophils and monocytes is significantly up-regulated after stimulation with granulocyte colony-stimulating factor during CHOP chemotherapy for patients with non-Hodgkin's lymphoma.

    abstract：:The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/BF02983535

    authors： Kakinoki Y,Kubota H,Yamamoto Y

    更新日期：2004-01-01 00:00:00

  • Stem and progenitor cells in human umbilical cord blood.

    abstract：:Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly i...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-010-0619-4

    authors： Lee MW,Jang IK,Yoo KH,Sung KW,Koo HH

    更新日期：2010-07-01 00:00:00

  • Successful unrelated donor bone marrow transplantation for Shwachman-Diamond syndrome with leukemia.

    abstract：:Shwachman-Diamond syndrome (SDS) is a rare congenital disorder featuring exocrine pancreatic insufficiency, growth retardation, and bone marrow dysfunction. Reports suggest that nearly 25% of all cases are complicated with leukemia. Although stem cell transplantation is the sole option for these patients, successful r...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1532/ijh97.03103

    authors： Mitsui T,Kawakami T,Sendo D,Katsuura M,Shimizu Y,Hayasaka K

    更新日期：2004-02-01 00:00:00

  • The myelodysplastic syndromes: morphology, risk assessment, and clinical management (2002).

    abstract：:The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/BF03165122

    authors： Bennett JM,Kouides PA,Forman SJ

    更新日期：2002-08-01 00:00:00

  • Anti-tissue factor pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia.

    abstract：:Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s12185-018-2548-6

    authors： Chowdary P

    更新日期：2020-01-01 00:00:00

  • AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.

    abstract：:Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) Chinese. Ten single nucleotide polymorphisms (SNPs) were evaluated in Han and Tibetan patients with acute (A) a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1117-7

    authors： Buroker NE,Ning XH,Zhou ZN,Li K,Cen WJ,Wu XF,Zhu WZ,Scott CR,Chen SH

    更新日期：2012-08-01 00:00:00

  • Acute myeloid leukemia in clinical practice: a retrospective population-based cohort study in Miyazaki Prefecture, Japan.

    abstract：:We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acut...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-012-1146-2

    authors： Matsunaga T,Yamashita K,Kubuki Y,Toyama T,Imataki O,Maeda K,Kawano N,Satou S,Kawano H,Ishizaki J,Yoshida S,Kameda T,Sasaki T,Sekine M,Kamiunten A,Taniguchi Y,Hidaka T,Katayose K,K-Shimoda H,Shide K,Yamamoto S,Mo

    更新日期：2012-09-01 00:00:00

  • Prognostic value of cytogenetic findings in adults with acute myeloid leukemia.

    abstract：:The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the m...

    journal_title：International journal of hematology

    pub_type： 杂志文章,评审

    doi：

    authors： Mrózek K,Heinonen K,Bloomfield CD

    更新日期：2000-10-01 00:00:00

  • Circulating intranuclear proteins may play a role in development of disseminated intravascular coagulation in individuals with acute leukemia.

    abstract：:Intranuclear proteins, including high mobility group box 1 (HMGB1) and histone H3, released from inflammatory cells activate platelets and the coagulation systems, leading to development of disseminated intravascular coagulation (DIC) in individuals with sepsis. These observations prompted us to hypothesize that HMGB1...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-019-02798-5

    authors： Harada-Shirado K,Wang X,Mori H,Fukatsu M,Takahashi H,Shichishima-Nakamura A,Kimura S,Ohkawara H,Yamada S,Ito T,Ikezoe T

    更新日期：2020-03-01 00:00:00

  • Two cases showing clonal progression with full evolution from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome to myelodysplastic syndromes and leukemia.

    abstract：:We report 2 paroxysmal nocturnal hemoglobinuria (PNH) patients who were initially diagnosed with aplastic anemia and sequentially developed PNH, myelodysplastic syndromes (MDS), and leukemia. Flow cytometry and cytogenetic analysis showed the initial appearance and expansion of PNH clones, gradual replacement of PNH c...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Ishihara S,Nakakuma H,Kawaguchi T,Nagakura S,Horikawa K,Hidaka M,Asou N,Mitsuya H

    更新日期：2000-08-01 00:00:00

  • JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.

    abstract：:Myeloproliferative neoplasms (MPNs) constitute a group of phenotypically diverse chronic myeloid malignancies, characterized by clonal hematopoiesis and excessive production of terminally differentiated myeloid blood cells. The MPNs include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibro...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s12185-013-1295-y

    authors： Tanaka M,Yujiri T,Ito S,Okayama N,Takahashi T,Shinohara K,Azuno Y,Nawata R,Hinoda Y,Tanizawa Y

    更新日期：2013-03-01 00:00:00

  • Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial.

    abstract：:Cytomegalovirus (CMV) infection/reactivation is a serious complication after hematopoietic cell transplantation (HCT). The DNA vaccine ASP0113 contains two plasmids encoding CMV antigens (glycoprotein B and tegument phosphoprotein 65) that stimulate humoral and cellular immunity. Between June 2013 and February 2014, A...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s12185-016-2110-3

    authors： Mori T,Kanda Y,Takenaka K,Okamoto S,Kato J,Kanda J,Yoshimoto G,Gondo H,Doi S,Inaba M,Kodera Y

    更新日期：2017-02-01 00:00:00

  • Serum stem cell factor levels in patients with aplastic anemia.

    abstract：:Immune suppression of hematopoiesis has been implicated in the pathogenesis of acquired aplastic anemia. Similarly, abnormalities of T cells and bone marrow stromal cells have been reported in aplastic anemia, as has abnormal cytokine production. Stem cell factor (SCF) (also known as kit ligand, mast cell growth facto...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Nimer SD,Leung DH,Wolin MJ,Golde DW

    更新日期：1994-10-01 00:00:00

  • A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55(-)CD59(-) blood cells predicts platelet response.

    abstract：:Although immunosuppressive therapy using antithymocyte globulin or cyclosporine A (CSA) is effective in selected patients with low-risk myelodysplastic syndrome, the response rates reported so far are inconsistent, and the indication of immunosuppressive therapy for myelodysplastic syndrome has not been clearly define...

    journal_title：International journal of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1532/IJH97.07052

    authors： Ishikawa T,Tohyama K,Nakao S,Yoshida Y,Teramura M,Motoji T,Takatoku M,Kurokawa M,Mitani K,Uchiyama T,Omine M

    更新日期：2007-08-01 00:00:00

  • Serial monitoring of T315I BCR-ABL mutation by Invader assay combined with RT-PCR.

    abstract：:We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months a...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1007/s12185-009-0290-9

    authors： Yamamoto M,Kakihana K,Ohashi K,Yamaguchi T,Tadokoro K,Akiyama H,Sakamaki H

    更新日期：2009-05-01 00:00:00

  • A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.

    abstract：:Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of...

    journal_title：International journal of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s12185-015-1852-7

    authors： Nomoto H,Takami A,Espinoza JL,Matsuo K,Mizuno S,Onizuka M,Kashiwase K,Morishima Y,Fukuda T,Kodera Y,Doki N,Miyamura K,Mori T,Nakao S,Ohtake S,Morishita E

    更新日期：2015-10-01 00:00:00

  • Successful treatment of two patients with primary cardiac malignant lymphoma.

    abstract：:We describe two patients with primary cardiac malignant lymphoma involving the right atrium and superior vena cava, resulting in intractable right cardiac failure and superior vena cava syndrome. Patients were diagnosed by surgical myocardial biopsy and were treated with combination chemotherapy for non-Hodgkin's lymp...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：

    authors： Enomoto S,Abo T,Sugawara T,Ishida Y,Murai K,Itoh S,Kuriya S

    更新日期：1999-10-01 00:00:00

  • Two patients with all-trans retinoic acid-resistant acute promyelocytic leukemia treated successfully with gemtuzumab ozogamicin as a single agent.

    abstract：:Acute promyelocytic leukemia (APL) cells express a considerable level of CD33, which is the target of gemtuzumab ozogamicin (GO), and a significantly lower level of P-glycoprotein (P-gp). Therefore, GO is predicted to be a successful treatment for APL. In this article, we report on the GO treatment of 2 patients with ...

    journal_title：International journal of hematology

    pub_type： 杂志文章

    doi：10.1532/IJH97.05069

    authors： Takeshita A,Shinjo K,Naito K,Matsui H,Sahara N,Shigeno K,Suzumura T,Horii T,Shirai N,Maekawa M,Yada Y,Teshima H,Takeuchi J,Ohnishi K,Ohno R

    更新日期：2005-12-01 00:00:00