Abstract:
:We recently developed an Invader assay combined with reverse transcriptase polymerase-chain-reaction in order to quantify T315I bcr-abl transcripts. Using this assay, we serially monitored T315I bcr-abl transcripts in chronic myeloid leukemia (CML) patients whose bcr-abl transcripts were still detectable at 6 months after starting imatinib therapy. Although, we continued to monitor bcr-abl transcripts in 14 CML patients (13 chronic phases and 1 accelerated phase) for up to 12 months, there were no patients who were apparently resistant to imatinib due to the T315I mutation. In contrast, in a case of Philadelphia chromosome-positive acute lymphoid leukemia being treated with chemotherapy including imatinib, we monitored both wild-type and T315I bcr-abl transcripts, and found increased levels of T315I transcripts during relapse (0% at the time of diagnosis and 54.8% at relapse). Thus, our new approach could be a useful tool to study the kinetics of mutant clones and the pharmacokinetics of drug resistance with regard to the T315I mutation.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Yamamoto M,Kakihana K,Ohashi K,Yamaguchi T,Tadokoro K,Akiyama H,Sakamaki Hdoi
10.1007/s12185-009-0290-9subject
Has Abstractpub_date
2009-05-01 00:00:00pages
482-488issue
4eissn
0925-5710issn
1865-3774pii
10.1007/s12185-009-0290-9journal_volume
89pub_type
杂志文章abstract::Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/ijh97.a10323
更新日期:2004-11-01 00:00:00
abstract::CCR4 is expressed on tumor cells of most patients with adult T-cell leukemia/lymphoma (ATL). Gain-of-function mutations of the CCR4 gene in ATL patients may be associated with alterations at the carboxyl terminus, a finding which led to a high efficacy anti-CCR4 antibody, mogamulizumab. Only a few studies have reporte...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-019-02728-5
更新日期:2019-10-01 00:00:00
abstract::Post-transplant lymphoproliferative disorders (PTLDs) are serious, life-threatening complications of solid-organ transplantation (SOT) and bone marrow transplantation, and are associated with high mortality. PTLDs represent a heterogeneous group of lymphoproliferative diseases, which show a spectrum of clinical, morph...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1244-1
更新日期:2013-01-01 00:00:00
abstract::High-dose melphalan followed by autologous hematopoietic stem cell transplantation (ASCT) is a standard treatment for younger myeloma patients. However, the correlation between its toxicity and renal impairment is not clear. We analyzed this relationship, focusing on estimated glomerular filtration rate (eGFR) as an i...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-018-2507-2
更新日期:2018-10-01 00:00:00
abstract::Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-020-02899-6
更新日期:2020-09-01 00:00:00
abstract::Hemoglobin E-beta thalassemia (Hb E/β-thalassemia) is a distinct, yet common, type of β-thalassemia, in which the patient co-inherits a β-thalassemia allele from one parent, and a structural variant, Hb E, from the other parent. This co-inheritance leads to remarkable clinical heterogeneity, varying degrees of chronic...
journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12185-017-2307-0
更新日期:2017-12-01 00:00:00
abstract::Jejunoileal involvement of non-Hodgkin's lymphoma (NHL) is an important diagnostic factor in determining optimal treatment strategies. Here, we used double-balloon enteroscopy (DBE) to detect jejunoileal involvement of NHL and studied its clinical significance in a series of patients with NHL. Adults aged between 18 a...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1273-4
更新日期:2013-03-01 00:00:00
abstract::African Burkitt lymphomas (BL) are highly aggressive lymphomas mainly affecting children and young adults in Africa. This lymphoma was marked by its high sensitivity to chemotherapy in comparison to Sporadic Burkitt lymphoma. In this study, we evaluated the treatment response and survival of patients with CMA protocol...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0591-z
更新日期:2010-06-01 00:00:00
abstract::Aberrant methylation in promoter-associated CpG islands has been recognized as a major mechanism for tumor suppressor gene silencing in several malignancies. We determined the methylation status of nine tumor suppressor genes in 68 newly diagnosed MM patients by methylation-specific PCR. The frequency of promoter hype...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0459-2
更新日期:2010-01-01 00:00:00
abstract::Previous studies have suggested that an increase in mitochondrial reactive oxygen species may cause organ damage in patients with light-chain (AL) amyloidosis; however, this damage can be decreased by antioxidant-agent treatment. Epigallocatechin gallate (EGCG), the major natural catechin in green tea, has potent anti...
journal_title:International journal of hematology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s12185-016-2112-1
更新日期:2017-03-01 00:00:00
abstract::In the original publication of this article, Tables 2, 3 and 4 were published incorrectly. The corrected tables 2, 3 and 4 are given in the following pages. ...
journal_title:International journal of hematology
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12185-018-2486-3
更新日期:2018-08-01 00:00:00
abstract::The Myelodysplastic Syndromes (MDS) represent a group of potentially acute myeloid leukemic disorders. There exists a delicate balance between increased apoptosis and proliferation of the leukemic hematopoietic stem cell that permits many patients to survive for years. When the balance shifts towards proliferation AML...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF03165122
更新日期:2002-08-01 00:00:00
abstract::Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in co...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/BF02982650
更新日期:2003-05-01 00:00:00
abstract::Hypocalcemic cardiomyopathy in primary or secondary hypoparathyroidism is usually refractory to conventional treatment of cardiac failure. We report the case of a thalassemic patient with severe cardiac failure that might have been attributed to several factors, such as hemosiderosis, hypomagnesemia, and hypocalcemia,...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.E0532
更新日期:2006-05-01 00:00:00
abstract::We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1759-3
更新日期:2015-07-01 00:00:00
abstract::IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-017-2315-0
更新日期:2017-12-01 00:00:00
abstract::Although immunosuppressive therapy using antithymocyte globulin or cyclosporine A (CSA) is effective in selected patients with low-risk myelodysplastic syndrome, the response rates reported so far are inconsistent, and the indication of immunosuppressive therapy for myelodysplastic syndrome has not been clearly define...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1532/IJH97.07052
更新日期:2007-08-01 00:00:00
abstract::Stem cell transplantations were performed in 69 children at Siriraj Hospital over a ten year period. The source of stem cells was bone marrow (60), peripheral blood (3), or cord blood (6). The diseases treated included 35 thalassemias, 11 Burkitt's lymphoma, five non-Hodgkin's lymphoma, five aplastic anemia, eight acu...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1016/s0925-5710(98)00083-8
更新日期:1998-12-01 00:00:00
abstract::Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02981907
更新日期:2001-01-01 00:00:00
abstract::To assess response to cyclosporine A, and/or corticosteroids, and possible factors influencing the response in adult patients with acquired pure red cell aplasia (PRCA). Clinical data from 42 cases were retrospectively analyzed. These patients received cyclosporine A (CsA), and/or corticosteroids (CS), or other immuno...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-2446-y
更新日期:2018-08-01 00:00:00
abstract::To investigate the expression of activation molecules on CD5(+)B lymphocytes in peripheral blood of autoimmune hemolytic anemia (AIHA)/Evans patients. The expression of CD80, CD86, and CD69 on CD5(+)B lymphocytes was detected using flow cytometry in 30 AIHA/Evans patients, 18 normal controls (NC) and nine chronic lymp...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-1964-8
更新日期:2016-05-01 00:00:00
abstract::A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(96)00549-x
更新日期:1997-02-01 00:00:00
abstract::The relative risk of non-Hodgkin's lymphoma (NHL) among patients infected with human immunodeficiency virus (HIV) is elevated compared with the general population. We describe a retrospective study of 78 HIV-infected patients with NHL treated between 1999 and 2006 at the Infectology Institute, a reference center for H...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06116
更新日期:2006-11-01 00:00:00
abstract::An inherited antithrombin deficiency is an autosomal dominant thrombotic disorder. We identified two pedigrees of inherited type I antithrombin deficiency and two responsible mutations in each. A novel 21-22delAA appeared to have caused a frameshift with a premature termination at amino acid +63 in one patient and a l...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0763-x
更新日期:2011-02-01 00:00:00
abstract::We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1873-2
更新日期:2015-12-01 00:00:00
abstract::Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s12185-015-1852-7
更新日期:2015-10-01 00:00:00
abstract::Bortezomib and melphalan have synergistic effects against multiple myeloma (MM) cells. We conducted a pilot study on the combination of bortezomib and high-dose melphalan (Bor-HDM) as a conditioning regimen followed by autologous stem cell transplant (ASCT) in 17 Japanese patients with newly diagnosed MM, in compariso...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s12185-013-1402-0
更新日期:2013-09-01 00:00:00
abstract::Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0966-9
更新日期:2011-12-01 00:00:00
abstract::Thirty patients with hematologic diseases received allogeneic hematopoietic stem cell transplants (HSCT) from related donors other than genotypically HLA-matched siblings. Their outcomes were compared with those of 102 patients who had received HSCT from genotypically HLA-matched siblings. All donors in the study grou...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02982696
更新日期:2002-11-01 00:00:00
abstract::A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1481-y
更新日期:2014-02-01 00:00:00