Abstract:
:IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 polymorphism between DLBCL patients and controls. However, the 2-year PFS rate of patients with the IKZF1 TT genotype was 54.3% compared to 68.6% in those with the IKZF1 G+ genotypes. Moreover, the IKZF1 rs4132601 polymorphism retained its independent prognostic impact on PFS. A more pronounced effect of the IKZF1 TT genotype on PFS was detected in patients with low/intermediate low IPI-risk group. When analysis was restricted to patients with GCB-type pattern, those with the IKZF1 TT genotype achieved a lower 5-year OS rate than the patients with the IKZF1 G+ genotypes (19.6 vs. 56%). This study provides the first evidence for the association of IKZF1 variants with DLBCL outcome.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Bielska M,Borowiec M,Jesionek-Kupnicka D,Braun M,Bojo M,Pastorczak A,Kalinka-Warzocha E,Prochorec-Sobieszek M,Robak T,Warzocha K,Młynarski W,Lech-Marańda Edoi
10.1007/s12185-017-2315-0subject
Has Abstractpub_date
2017-12-01 00:00:00pages
794-800issue
6eissn
0925-5710issn
1865-3774pii
10.1007/s12185-017-2315-0journal_volume
106pub_type
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