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Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis.

Abstract：

:Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the active stage. In the convalescent stage, the levels of sFasL decreased to an undetectable degree after 2 weeks. These findings indicate the possibility that sFasL plays an important role in the constitutional symptoms and pathogenesis of HNL and, furthermore, that it can act as a surrogate marker of the disease activity.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

doi

10.1007/BF02981907

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

84-6

issue

1

eissn

0925-5710

issn

1865-3774

journal_volume

73

pub_type

杂志文章

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