Abstract:
:Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in combination with cyclosporine or antilymphocyte globulin (ALG). Both patients obtained partial remission in response to the immunosuppressive therapy and did not need transfusion treatment for more than 3 years. Sustained improvement of hematopoiesis in such B-cell malignancies after ATG/ ALG therapy suggests that the mechanisms underlying successful immunosuppressive therapy for aplastic anemia may involve B-cell suppression, inhibiting hematopoietic stem cells.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Sugimori C,Kaito K,Nakao Sdoi
10.1007/BF02982650subject
Has Abstractpub_date
2003-05-01 00:00:00pages
391-4issue
4eissn
0925-5710issn
1865-3774journal_volume
77pub_type
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