Abstract:
:It has been reported that Nak(a)-negative platelets lack GP IV. To examine the GP IV genetic defects in Nak(a)-negative platelets, we studied four unrelated Nak(a)-negative subjects by amplifying their GP IV cDNA, which were synthesized from platelet mRNA using the reverse transcriptase/polymerase chain reaction (RT/PCR). We detected the entire coding region of GP IV mRNA in the platelets of all four subjects. Restriction enzyme analysis of the amplified GP IV cDNA showed fully predictable cutting sites. These results suggest that no gross deletion or insertion had occurred in the GP IV mRNA of Nak(a)-negative platelets.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Kashiwagi H,Honda S,Take H,Mizutani H,Imai Y,Furubayashi T,Tomiyama Y,Kurata Y,Yonezawa Tsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
153-61issue
2eissn
0925-5710issn
1865-3774journal_volume
57pub_type
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