Abstract:
:Type-1 cryoglobulinemic vasculitis (CV) and mixed CV differ in their pathophysiology, clinical expression and treatment response. We report one patient with type-1 cryoglobulinemic vasculitis and skin ulcers that had remained active despite treatment with a variety of immunomodulating drugs including rituximab. The patient had a past medical history of non-Hodgkin lymphoma 10 years after CV onset for which she went into complete remission. The patient developed subsequent hematological anomalies in the serum and in the bone marrow without a definite diagnosis of myeloma. The patient finally went into clinical remission of her cryoglobulinemic vasculitis after treatment with bortezomib and dexamethasone. But she did not achieve an immunological remission and still had positive cryoglobulinemia and serum kappa-type free light chains. This suggests that bortezomib, a proteasome inhibitor that inhibits angiogenesis and production of paraproteins, is a promising treatment in type-1 cryoglobulinemic vasculitis.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Besada E,Vik A,Koldingsnes W,Nossent JCdoi
10.1007/s12185-013-1323-ysubject
Has Abstractpub_date
2013-06-01 00:00:00pages
800-3issue
6eissn
0925-5710issn
1865-3774journal_volume
97pub_type
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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journal_title:International journal of hematology
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of hematology
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pub_type: 杂志文章,多中心研究
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journal_title:International journal of hematology
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