Involvement of the BCL3 gene in two patients with chronic lymphocytic leukemia.


:The t(14;19)(q32;q13) is a recurring translocation found in some patients with chronic lymphocytic leukemia (CLL), and the t(14;19) juxtaposes the BCL3 gene on chromosome 19 with the immunoglobulin heavy chain gene (IGH) locus on chromosome 14. Genomic DNAs from 49 patients with chronic B-cell leukemia and the related lymphomas were examined by Southern blot hybridization using 2 separate probes, named p alpha 1.4P and p alpha .5B, from the BCL3 gene locus. None of the 18 patients with leukemic manifestations of non-Hodgkin's lymphomas had detectable BCL3 rearrangements. Of 31 patients with CLL, 2 had the BCL3 rearrangements. A comigration study using the C alpha and C epsilon constant gene probe from IGH indicated that the t(14;19) translocation occurred in these 2 patients, and they were diagnosed with CLL/prolymphocytic (PL) according to the French-American-British (FAB) classification. Probes for the IGH locus revealed that leukemia cells of the 2 patients each were clonal, indicating that both small lymphocytes and prolymphocytoid cells found in the peripheral blood of one patient had the t(14;19), as well as a major population of the small lymphocytes in the peripheral blood of a second patient. It thus appears that tumor cells carrying the t(14;19) constitute a distinct disease entity in a group of chronic B-cell leukemia, that has a converting potential to more aggressive forms.


Int J Hematol


Yabumoto K,Ohno H,Doi S,Edamura S,Arita Y,Akasaka T,Matsumoto J,Kadowaki N,Fukuhara S,Okuma M


Has Abstract


1994-04-01 00:00:00












  • Symptomatic severe hypertriglyceridaemia with asparaginase therapy in acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma: is rechallenging safe?

    abstract::Severe hyperlipidaemia with asparaginase therapy is rare. We report six cases, four of which developed significant problems with severe hyperlipidaemia during induction therapy for ALL and lymphoblastic lymphoma. The median triglyceride level was 22.3 mmol/L and the median cholesterol level was 12.3 mmol/L. None of th...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Lashkari HP,Lancaster D,Atra A,Champion MP,Taj MM

    更新日期:2011-12-01 00:00:00

  • The three isoforms of hepcidin in human serum and their processing determined by liquid chromatography-tandem mass spectrometry (LC-tandem MS).

    abstract::Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

    更新日期:2016-01-01 00:00:00

  • Secondary abnormalities involving 1q or 13q and poor outcome in high stage Burkitt leukemia/lymphoma cases with 8q24 rearrangement at diagnosis.

    abstract::Classical Burkitt lymphoma/leukemia (BL/L) presenting L3 morphology is found in 1% of childhood ALL. Recently, it has been described that secondary abnormalities could influence the prognosis of these patients. However, little information is available on these cytogenetic abnormalities and their prognostic importance ...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: de Souza MT,Mkrtchyan H,Hassan R,Ney-Garcia DR,de Azevedo AMB,da Costa ES,de Figueiredo AF,Liehr T,Abdelhay E,Silva MLM

    更新日期:2011-02-01 00:00:00

  • CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement.

    abstract::A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical ski...

    journal_title:International journal of hematology

    pub_type: 信件


    authors: Asano H,Imai Y,Ota S,Yamamoto G,Takahashi T,Fukayama M,Kurokawa M

    更新日期:2010-10-01 00:00:00

  • Gemcitabine-induced large vessel vasculitis demonstrated by PET CT: a rare, important side effect.

    abstract::Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

    更新日期:2014-06-01 00:00:00

  • Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles.

    abstract::Recent evidence suggests that mesenchymal stem cells (MSC) selectively home to tumors, where they contribute to the formation of tumor-associated stroma. This effect can be opposed by genetically modifying MSC to produce high levels of anti-cancer agents that blunt tumor growth kinetics and inhibit the growth of tumor...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Hall B,Dembinski J,Sasser AK,Studeny M,Andreeff M,Marini F

    更新日期:2007-07-01 00:00:00

  • Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis.

    abstract::Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

    更新日期:2001-01-01 00:00:00

  • A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations.

    abstract::Cytomegalovirus (CMV) infection is latent in the majority of adult humans. The reactivation of CMV causes pneumonia and gastrointestinal disease in severely immunosuppressed patients, who consequently suffer very high mortality due to CMV central nervous system disease. We report here a case involving a 28-year-old fe...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Matsukawa T,Goto H,Takahashi K,Asanuma S,Yasumoto A,Takahata M,Shigematsu A,Endo T,Tanaka J,Hashino S,Tanaka S,Imamura M

    更新日期:2012-02-01 00:00:00

  • Brief induction chemotherapy followed by involved-field irradiation for the treatment of localized intermediate- and high-grade non-Hodgkin's lymphoma.

    abstract::In an attempt to assess the effects and toxicity of brief induction chemotherapy plus involved-field irradiation for localized intermediate- and high-grade non-Hodgkin's lymphoma, we conducted a single-arm prospective trial between May 1987 and July 1991. Patients received four cycles of a five-drug chemotherapy regim...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Ohnoshi T,Hayashi K,Mizuta J,Tagawa S,Matsutomo S,Saito S,Kawashima K,Akagi T,Kimura I

    更新日期:1993-01-01 00:00:00

  • Lymphoma epidemiology in Korea and the real clinical field including the Consortium for Improving Survival of Lymphoma (CISL) trial.

    abstract::Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Yoo KH,Lee H,Suh C,CISL.

    更新日期:2018-04-01 00:00:00

  • Multicenter, prospective study to evaluate the efficacy of biweekly romiplostim administration in patients with immune thrombocytopenia.

    abstract::Multicenter, prospective study was conducted to evaluate the efficacy of biweekly romiplostim in maintaining platelet ≥ 30 × 10(9)/L for at least 4 weeks. Treatment was started with a weekly injection (1 mcg/kg), and the dose was escalated until a titrated dose was achieved that maintained a platelet 50-200 × 10(9)/L ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,多中心研究


    authors: Park S,Yoon SS,Lee JH,Park JS,Jang JH,Lee JW

    更新日期:2016-01-01 00:00:00

  • Immune dysregulation syndrome with de novo CTLA4 germline mutation responsive to abatacept therapy.

    abstract::Regulatory T-cells (Tregs) are major mediators of mammalian self-tolerance via cytotoxic T-lymphocyte antigen 4 (CTLA4) signaling pathways. An immune dysregulation syndrome associated with heterozygous germline mutations in CTLA4 was recently reported. Clinical features include recurrent infections, systemic lymphaden...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Ureshino H,Koarada S,Kamachi K,Yoshimura M,Yokoo M,Kubota Y,Ando T,Ichinohe T,Morio T,Kimura S

    更新日期:2020-06-01 00:00:00

  • Heparin-induced thrombocytopenia: molecular pathogenesis.

    abstract::Heparin-induced thrombocytopenia (HIT) is a common and often serious complication of heparin therapy [1,2]. Although the reduction in platelet levels associated with HIT is usually not severe, about 10% of patients experience arterial and/or venous thromboses (HITT), which can be incapacitating or fatal [3]. Recent wo...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Lee SH,Liu CY,PaoloVisentin G

    更新日期:2002-08-01 00:00:00

  • Immunodeficient mouse models of lymphoid tumors.

    abstract::Severe combined immunodeficient (SCID) mice lack functional T- and B-cells and readily accept human xenografts, including hematopoietic malignancies. Accordingly, SCID mice have been used to study the growth and behavior of lymphoid tumors in vivo. The SCID mouse models of disease mimic human diseases and have provide...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Imada K

    更新日期:2003-05-01 00:00:00

  • IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.

    abstract::Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Hosgood HD 3rd,Au WY,Kim HN,Liu J,Hu W,Tse J,Song B,Wong KF,Lee JJ,Chanock SJ,Siu LP,Purdue MP,Shin MH,Yu J,Liang R,Kim HJ,Rothman N,Lan Q

    更新日期:2013-06-01 00:00:00

  • Iron metabolism in erythroid cells and patients with congenital sideroblastic anemia.

    abstract::Sideroblastic anemias are anemic disorders characterized by the presence of ring sideroblasts in a patient's bone marrow. These disorders are typically divided into two types, congenital or acquired sideroblastic anemia. Recently, several genes were reported as responsible for congenital sideroblastic anemia; however,...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Furuyama K,Kaneko K

    更新日期:2018-01-01 00:00:00

  • Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy.

    abstract::To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura (ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-mediu...

    journal_title:International journal of hematology

    pub_type: 临床试验,杂志文章


    authors: Kondo H,Iseki T,Goto S,Takaso T,Ohto M,Okuda K

    更新日期:1992-06-01 00:00:00

  • Tuberculosis-associated hemophagocytic syndrome in a hemodialysis patient with protracted fever.

    abstract::Hemophagocytic syndrome (HPS) is a clinicopathological reflection of uncontrolled activation of macrophages. To our knowledge, only a few cases of tuberculosis-associated HPS in hemodialysis have been reported in the English literature. We report a case of tuberculosis-associated HPS during hemodialysis. Bone marrow a...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Chien CC,Chiou TJ,Lee MY,Hsiao LT,Kwang WK

    更新日期:2004-05-01 00:00:00

  • Percentages of bone marrow blasts and chromosomal changes in patients with refractory anemia help to determine prognoses.

    abstract::We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Iwabuchi A,Ohyashiki K,Ohyashiki JH,Kimura Y,Lin KY,Aizawa S,Nehashi Y,Miyazawa K,Yaguchi M,Toyama K

    更新日期:1994-10-01 00:00:00

  • Predictors of anxiety and depression in Egyptian thalassemic patients: a single center study.

    abstract::Thalassemic patients are vulnerable to emotional and behavioral problems. Each patient age group exhibits problems unique to that stage of development, and although up to 80 % of thalassemic patients are likely to have psychological disorders, e.g., anxiety and depression, predictors of these disorders remain poorly u...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yahia S,El-Hadidy MA,El-Gilany AH,Anwar R,Darwish A,Mansour AK

    更新日期:2013-05-01 00:00:00

  • PTCL: lessons from adult T-cell leukemia.

    abstract::Peripheral T-cell lymphoma (PTCL) is a neoplastc disease of peripheral T-lymphocytes/NK cells, including PTCL unspecified, anaplastic large T-cell lymphoma (ALCL), IBL-like T-cell lymphoma (AILD), intestinal T-cell lymphoma (ITCL) and adult T-cell leukemia/lymphoma (ATL). The incidence of PTCL is relatively uncommon a...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Matsuoka M

    更新日期:2002-08-01 00:00:00

  • Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency.

    abstract::Integrins, a family of noncovalently associated alpha beta heterodimeric adhesion receptors, are involved in a variety of pathological and physiological processes. The importance of integrins is evident in the severe pathogenic consequences of their congenital deficiencies: Glanzmann thrombasthenia (GT) and leukocyte ...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Tomiyama Y

    更新日期:2000-12-01 00:00:00

  • Dilated cardiomyopathy during the course of hemolytic uremic syndrome.

    abstract::A 47-year-old woman presented with severe hemolytic uremic syndrome (HUS) followed by heart failure. An echocardiogram showed an ejection fraction of 20%, and a cardiac catheterization followed by a myocardial histologic evaluation demonstrated dilated cardiomyopathy. Plasma exchange and hemodialysis were performed re...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Alexopoulou A,Dourakis SP,Zovoilis C,Agapitos E,Androulakis A,Filiotou A,Archimandritis AJ

    更新日期:2007-11-01 00:00:00

  • Pediatric post-transplant diffuse large B cell lymphoma after cardiac transplantation.

    abstract::Post-transplant lymphoproliferative disorders (PTLDs) occur in 3.5-9% of patients after pediatric cardiac transplantation. Caution is needed when treating patients with PTLD because of the risk of allograft rejection frequently caused by withdrawal of immunosuppression. In this report, we describe a 47-month-old boy w...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kusuki S,Hashii Y,Fukushima N,Takizawa S,Tokimasa S,Kogaki S,Ohta H,Tsuda E,Nakagawa A,Ozono K

    更新日期:2009-03-01 00:00:00

  • Occurrence of lymphoplasmacytic lymphoma 6 years after amelioration of primary cold agglutinin disease by rituximab therapy.

    abstract::Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia, classified into primary and secondary types. Secondary CAD accompanies infection or malignant disease, most often lymphoma, whereas primary CAD frequently represents a lymphoproliferative bone marrow disorder characterized by clonal expansion of B ce...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Tanaka H,Hashimoto S,Sugita Y,Sakai S,Takeda Y,Abe D,Takagi T,Nakaseko C

    更新日期:2012-10-01 00:00:00

  • Benefit of simultaneous rhG-CSF and methylprednisolone 'pulse' therapy for methotrexate-induced bone marrow failure in rheumatoid arthritis.

    abstract::A 74-year-old female with seropositive rheumatoid arthritis developed severe bone marrow failure after the treatment with very low-dose methotrexate (5 mg/week for 3 weeks). Hematological data showed severe pancytopenia with 0% neutrophils and bone marrow disclosed thoroughly hypocellular marrow. Shortly after the tre...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kondo H,Date Y

    更新日期:1997-02-01 00:00:00

  • Importance of CD4+ helper T-cells in antitumor immunity.

    abstract::CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding o...

    journal_title:International journal of hematology

    pub_type: 杂志文章,评审


    authors: Shiku H

    更新日期:2003-06-01 00:00:00

  • A decision analysis comparing unrelated bone marrow transplantation and cord blood transplantation in patients with aggressive adult T-cell leukemia-lymphoma.

    abstract::Patients with aggressive adult T-cell leukemia-lymphoma (ATL) have dismal outcomes with intensive chemotherapy. Early up-front allogeneic hematopoietic stem cell transplantation (allo-HSCT) is generally recommended. However, the choice of stem cell source, i.e., unrelated bone marrow transplant (UBMT) or cord blood tr...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Fuji S,Kurosawa S,Inamoto Y,Murata T,Utsunomiya A,Uchimaru K,Yamasaki S,Inoue Y,Moriuchi Y,Choi I,Ogata M,Hidaka M,Yamaguchi T,Fukuda T

    更新日期:2020-03-01 00:00:00

  • Aplastic anemia with circulating erythroblasts.

    abstract::Since the presence of erythroblasts (Ebl) in the peripheral blood of patients suspected to have aplastic anemia (AA) has been thought to suggest an error in diagnosis, such patients may not receive appropriate therapy promptly, with potentially fatal results. However, we recently experienced patients who had the typic...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Yokose N,Ogata K,Dan K,Nomura T

    更新日期:1994-08-01 00:00:00

  • Relative increase in lymphocytes from as early as 1 month predicts improved response to dasatinib in chronic-phase chronic myelogenous leukemia.

    abstract::Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

    journal_title:International journal of hematology

    pub_type: 杂志文章


    authors: Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

    更新日期:2014-01-01 00:00:00