Abstract:
:The prognosis of pulmonary toxoplasmosis, including disseminated toxoplasmosis involving the lungs, following hematopoietic stem cell transplantation (HSCT) is extremely poor due to the difficulties associated with early diagnosis and the rapidly progressive deterioration of multiorgan function. In our institution, we identified nine cases of toxoplasmosis, representing incidences of 2.2 and 19.6 % among all HSCT recipients and seropositive HSCT recipients, respectively. Of the patients with toxoplasmosis, six had pulmonary toxoplasmosis. Chest computed tomography (CT) findings revealed centrilobular, patchy ground-glass opacities (n = 3), diffuse ground-glass opacities (n = 2), ground-glass opacities with septal thickening (n = 1), and marked pleural effusion (n = 1). All cases died, except for one with suspected pulmonary toxoplasmosis who was diagnosed by a polymerase chain reaction assay 2 days after the onset of symptoms. In pulmonary toxoplasmosis, CT findings are non-specific and may mimic pulmonary congestion, atypical pneumonia, viral pneumonitis, and bronchopneumonia. Early diagnosis and treatment is crucial for overcoming this serious infectious complication. Pulmonary toxoplasmosis should be considered during differential diagnosis in a recipient with otherwise unexplained signs of infection and CT findings with ground-glass opacities, regardless of the distribution.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Sumi M,Norose K,Hikosaka K,Kaiume H,Takeda W,Kirihara T,Kurihara T,Sato K,Ueki T,Hiroshima Y,Kuraishi H,Watanabe M,Kobayashi Hdoi
10.1007/s12185-016-2077-0subject
Has Abstractpub_date
2016-12-01 00:00:00pages
729-740issue
6eissn
0925-5710issn
1865-3774pii
10.1007/s12185-016-2077-0journal_volume
104pub_type
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