Abstract:
:We evaluated the efficacy and toxicity of a new salvage regimen, consisting of rituximab (375 mg/m(2), day 1), ifosfamide (1500 mg/m(2) on days 3-7), etoposide (150 mg/m(2), days 3-5), cytarabine (100 mg/m(2), days 3-5) and dexamethasone (40 mg/body, days 3-5) (R-IVAD) for relapsed or refractory aggressive B-cell lymphoma. In this study, a total of 32 patients with a median age of 64 years (range 38-79) who received an average of 2.6 cycles of R-IVAD from 2001 to 2009 in our institution were retrospectively analyzed. R-IVAD was given every 3 weeks up to a total of three courses with support by granulocyte colony stimulating factor. The overall response rate was 72%, with 56% complete response. On a median follow-up of 16 months (range 2-99), estimated 2-year overall survival (OS) and event-free survival were 55% and 36%, respectively. Of these patients, 10 successfully proceeded to consolidating high-dose chemotherapy followed by autologous stem cell transplantation, accounting for 90% of the 2-year OS. No treatment-related mortality was observed during the investigation. We, therefore, conclude that R-IVAD regimen is a safe and efficacious alternative for patients with relapsed or refractory aggressive B-cell lymphoma.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Miura K,Takei K,Kobayashi S,Kiso S,Hirabayashi Y,Hojo A,Kodaira H,Yagi M,Kurita D,Kobayashi Y,Tanaka T,Iriyama N,Hatta Y,Kura Y,Yamazaki T,Sawada U,Takeuchi Jdoi
10.1007/s12185-011-0884-xsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
90-96issue
1eissn
0925-5710issn
1865-3774pii
10.1007/s12185-011-0884-xjournal_volume
94pub_type
杂志文章abstract::Chimeric antigen receptor (CAR)-modified T cells have generated broad interest in oncology following a series of dramatic clinical successes in patients with chemorefractory B cell malignancies. CAR therapy now appears to be on the cusp of regulatory approval as a cell-based immunotherapy. We review here the T cell bi...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1007/s12185-016-2039-6
更新日期:2016-07-01 00:00:00
abstract::The present study was performed to examine whether the expression of CD64 Fc gamma receptor type I (FcgammaRI) on both neutrophils and monocytes can be modulated by multiple daily administrations of granulocyte colony-stimulating factor (G-CSF) to patients with non-Hodgkin's lymphoma in neutropenia caused by CHOP (cyc...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983535
更新日期:2004-01-01 00:00:00
abstract::A phase 1/2 study was conducted to assess the safety and efficacy of dasatinib in Japanese patients with chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) resistant or intolerant to imatinib. In phase 1, 18 patients with chronic phase (CP) CML were treated ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0260-2
更新日期:2009-04-01 00:00:00
abstract::The correlation between infant leukemia and in utero exposure to topoisomerase II (topo-II) inhibitor has been clarified. We examined the in vitro effect of topo-II inhibitor (etoposide) on cleavage of the MLL gene in cord and peripheral blood mononuclear cells (MNCs). Southern blot analysis showed cleavage of the MLL...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02982722
更新日期:2002-07-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is an autoimmune disorder described as autoantibody-mediated platelet deterioration. Platelets with affiliated IgG are targeted for exploitation by Fc receptor-mediated phagocytic cellular material within the reticuloendothelial system. The objective of this research is to investigate the...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-012-1187-6
更新日期:2012-11-01 00:00:00
abstract::Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lym...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1256-x
更新日期:2013-02-01 00:00:00
abstract::The percentage of myeloperoxidase (MPO)-positive blast cells is a simple and highly significant prognostic factor in AML patients. It has been reported that the high MPO group (MPO-H), in which >50% of blasts are MPO activity positive, is associated with favorable karyotypes, while the low MPO group (≤50% of blasts ar...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-011-0883-y
更新日期:2011-07-01 00:00:00
abstract::Fas stimulation has been reported to promote the activation and proliferation of T lymphocytes, but the intracellular signalling pathways that mediate non-apoptotic responses to Fas are poorly defined. To distinguish between the activation signalling and the death-inducing pathway downstream of Fas, we generated a nov...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-010-0637-2
更新日期:2010-09-01 00:00:00
abstract::We describe two episodes of CMV retinitis in a pediatric patient who underwent a CD34+ selected graft from his haploidentical father. Both recipient and donor were cytomegalovirus (CMV) seropositive. Both episodes occurred late post-grafting during a phase of complete immunological recovery with sufficient numbers of ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0126-z
更新日期:2008-09-01 00:00:00
abstract::A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1806-0
更新日期:2015-10-01 00:00:00
abstract::We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemi...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-018-02567-w
更新日期:2019-02-01 00:00:00
abstract::Multiple myeloma is a disease involving the clonal evolution of plasma cells that produce monoclonal immunoglobulin; however, other products, such as ammonia and amylase, reportedly are secreted by neoplastic plasma cells. We describe a patient with immunoglobulin A (IgA) myeloma who showed a high serum level of carci...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06169
更新日期:2007-02-01 00:00:00
abstract::The gene for the DNA-repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), which is closely related with cellular sensitivity to alkylating agents, is inactivated by promoter hypermethylation in several human cancers, including malignant lymphoma. Promoter hypermethylation of the MGMT gene is a favorable progno...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1532/IJH97.06087
更新日期:2006-10-01 00:00:00
abstract::We developed an efficient differentiation induction system (OP9 system) from mouse embryonic stem (ES) cell to blood cells by coculture on a novel stromal cell line, OP9. This stromal cell line does not produce functional macrophage colony-stimulating factor (M-CSF) and presumably the deficiency of M-CSF production of...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1016/s0925-5710(96)00531-2
更新日期:1996-12-01 00:00:00
abstract::A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-013-1481-y
更新日期:2014-02-01 00:00:00
abstract::Hairy cell leukemia (HCL) is a rare type of chronic B-cell leukemia characterized by the hairy morphology of the leukemia cells. All of 5 HCL samples and an HCL-derived cell line, BNBH-I, showed serrated edges and hairlike projections in May-Grünwald Giemsa stain and protruding actin spikes and lamellipodia in phalloi...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/BF02983784
更新日期:2003-04-01 00:00:00
abstract::Hodgkin lymphoma (HL) is a rare subtype of malignant lymphoma in Japan, and there are few reports of HL in Japan in recent years. We retrospectively analyzed the clinical features of 139 patients with HL who were diagnosed and treated at our institution between 1997 and 2011. The median age at diagnosis was 34 years w...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-016-2007-1
更新日期:2016-08-01 00:00:00
abstract::Clonality analysis utilizing X-chromosome inactivation has been used in the study of various diseases, including hematological malignancies. The human androgen receptor gene (HUMARA) assay is the newest of such methods, and the majority of the female population can be assessed by this relatively simple procedure. One ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:
更新日期:1999-06-01 00:00:00
abstract::Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-008-0233-x
更新日期:2009-03-01 00:00:00
abstract::We performed a retrospective population-based cohort study of acute myeloid leukemia (AML) in Miyazaki Prefecture, Japan. Over 6 years, we diagnosed 221 patients (211 adults and 10 children) with AML, indicating an incidence of AML in Miyazaki Prefecture of 3.2 per 100,000 per year. In 193 adult patients with non-acut...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-012-1146-2
更新日期:2012-09-01 00:00:00
abstract::Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/...
journal_title:International journal of hematology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s12185-018-2520-5
更新日期:2018-12-01 00:00:00
abstract::APOBEC3G has been identified as an anti-human immunodeficiency virus type 1 (HIV-1) host factor that belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand DNA of HIV-1. The accumulating evidence de...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:10.1532/IJH97.05187
更新日期:2006-04-01 00:00:00
abstract::The NOTCH and nuclear factor kappa B (NF-κB) pathways are both constitutively activated in Chronic Lymphocytic Leukemia (CLL). We first described the NOTCH1 PEST domain mutation in a CLL subgroup, but the activation of the NOTCH pathway in NOTCH1-unmutated cases remains unexplained. Here, we investigated whether genet...
journal_title:International journal of hematology
pub_type: 临床试验,杂志文章
doi:10.1007/s12185-013-1368-y
更新日期:2013-08-01 00:00:00
abstract::Although immunosuppressive therapy using antithymocyte globulin or cyclosporine A (CSA) is effective in selected patients with low-risk myelodysplastic syndrome, the response rates reported so far are inconsistent, and the indication of immunosuppressive therapy for myelodysplastic syndrome has not been clearly define...
journal_title:International journal of hematology
pub_type: 杂志文章,多中心研究
doi:10.1532/IJH97.07052
更新日期:2007-08-01 00:00:00
abstract::The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1745-9
更新日期:2015-05-01 00:00:00
abstract::Thymic mucosa-associated lymphoid tissue (MALT) lymphoma shows distinct immunological characteristics, such as the expression of the IgA isotype, the frequent presence of immunoglobulin abnormalities, and a strong association with autoimmune disease, especially Sjögren's syndrome (SjS). We report a case of thymic MALT...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0324-3
更新日期:2009-06-01 00:00:00
abstract::Autologous stem cell transplantation is considered the best post-induction therapy for multiple myeloma (MM). Therefore, therapy for myeloma should be chosen not only on the basis of efficacy, but also taking into account their impact on the hematopoietic stem cell compartment. We describe the case of a MM patient in ...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-009-0354-x
更新日期:2009-07-01 00:00:00
abstract::Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-015-1809-x
更新日期:2015-08-01 00:00:00
abstract::We report a patient with Ph1-positive acute lymphoblastic leukemia (ALL) having i(17q) in whom bony lesions were the initial clinical manifestation. The patient was a 53-year-old male who began to have pains in his left hip early in March 1985. Relevant findings on admission included: WBC 21,300/microliters; blast cel...
journal_title:International journal of hematology
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract::We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...
journal_title:International journal of hematology
pub_type: 杂志文章
doi:10.1007/s12185-014-1729-1
更新日期:2015-05-01 00:00:00