当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HEMATOLOGY期刊下所有文献 > Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: a large retrospective study.

Graft-versus-host disease (GvHD) of the tongue and of the oral cavity: a large retrospective study.

Abstract：

:Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/F = 1.4; median age was 48.6 years; the median follow-up was for up to 3 years and 6 months. Conditioning regimens included several drugs (e.g., busulfan, cyclophosphamide and fludarabine). In 11 cases, radiotherapy (RT) was also used. Patients treated with RT were more likely to have tooth decay requiring fillings (p = 0.029), to need canal root interventions (p = 0.005) and to have tartar requiring oral hygiene interventions (p = 0.011). Patients with a lymphoma diagnosis were more likely to develop perioral scleroderma and chronic oral GvHD (cGvHD) (p = 0.045). Oral acute GvHD (aGvHD) was seen in 26 patients (49.1%). 21 (39.6%) patients developed cGvHD. GvHD of the tongue was seen in 21 (40%) patients. Oral mucositis was seen in only 5 patients (9.4%). Conditioning regimens with RT are more likely to induce oral aGvHD. The tongue is often affected by GvHD.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Piccin A,Tagnin M,Vecchiato C,Al-Khaffaf A,Beqiri L,Kaiser C,Agreiter I,Negri G,Kob M,Di Pierro A,Vittadello F,Mazzoleni G,Eisendle K,Fontanella F

doi

10.1007/s12185-018-2520-5

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

615-621

issue

6

eissn

0925-5710

issn

1865-3774

pii

10.1007/s12185-018-2520-5

journal_volume

108

pub_type

杂志文章,meta分析,评审

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