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Evaluation of HNA-expressing cell line-based antigen capture systems and a solid-phase system for detecting HNA-1a antibodies.

Abstract：

:Granulocyte immunofluorescence and granulocyte agglutination tests are standard methods for detecting human neutrophil antigen (HNA) antibodies (Abs); however, these require a typed panel of neutrophils, which can be time-consuming to develop, and it remains difficult to determine antibody specificity in some cases. We established and evaluated four detection systems for HNA-1a Abs based on an HNA-1a-expressing cell line (KY cells) and antigen capture. We additionally evaluated a commercial solid-phase system. Eleven HNA-1a antibody-positive samples, including the World Health Organization Reference Reagent, and 40 serum samples derived from male blood donors were used as positive and negative control samples, respectively. Although specificity was >0.90 in all systems evaluated, the sensitivity varied among the systems. The KY cell-based monoclonal antibody specific immobilisation of granulocyte antigens (KY-MAIGA) system using certain, but not all, monoclonal Abs, and the solid-phase system revealed higher sensitivity than other systems. In conclusion, the KY-MAIGA and commercial solid-phase systems were superior in terms of specific and sensitive detection of HNA-1a Abs.

journal_name

Int J Hematol

journal_title

International journal of hematology

authors

Amakishi E,Irie Y,Nishizawa K,Kamada H,Nakajima F,Matsuyama N,Ishii H,Matsukura H,Yasui K,Hirayama F

doi

10.1007/s12185-015-1751-y

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

386-91

issue

4

eissn

0925-5710

issn

1865-3774

journal_volume

101

pub_type

杂志文章

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