Recovery of normal hematopoiesis after severe bone marrow aplasia induced by interferon-alpha in a patient with chronic myelogenous leukemia.

Abstract:

:We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-alpha (IFN-alpha) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-alpha treatment.

journal_name

Int J Hematol

authors

Hishida A,Yamamoto K,Kato C,Yokozawa T,Emi N,Tanimoto M,Saito H

doi

10.1007/BF02982603

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

55-9

issue

1

eissn

0925-5710

issn

1865-3774

journal_volume

77

pub_type

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