Abstract:
:We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-alpha (IFN-alpha) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colony stimulating factor (G-CSF). Administration of G-CSF resulted in a partial recovery of hematopoiesis, and after starting immunosuppressive therapy, the patient was no longer dependent on blood transfusions. Moreover, her bone marrow had no Philadelphia chromosome-positive clones. According to the results of the present case, bone marrow recovery can be achieved with immunosuppressive therapy and a fatal outcome avoided, even in CML patients suffering from sustained bone marrow aplasia during IFN-alpha treatment.
journal_name
Int J Hematoljournal_title
International journal of hematologyauthors
Hishida A,Yamamoto K,Kato C,Yokozawa T,Emi N,Tanimoto M,Saito Hdoi
10.1007/BF02982603subject
Has Abstractpub_date
2003-01-01 00:00:00pages
55-9issue
1eissn
0925-5710issn
1865-3774journal_volume
77pub_type
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pub_type: 临床试验,杂志文章,多中心研究
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