Stem and progenitor cells in human umbilical cord blood.

abstract：:Rh blood group antigens are associated with non-glycosylated human erythrocyte membrane proteins encoded by two closely related genes, RHCE and RHD, and with a glycoprotein, a critical co-expressing factor encoded by the RH50 gene. The sequence analysis of RHCE transcripts has revealed that RhE/e and C/c serological p...

journal_title：International journal of hematology

authors： Iwamoto S,Yamasaki M,Kawano M,Okuda H,Omi T,Takahashi J,Tani Y,Omine M,Kajii E

更新日期：1998-10-01 00:00:00

abstract：:The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluo...

journal_title：International journal of hematology

authors： Oh MY,Chung JS,Song MK,Shin HJ,Lee HS,Lee SM,Lee GW,Lee SE

更新日期：2013-03-01 00:00:00

abstract：:In vitro treatment of bone marrow cells to expand stem cells may lead to impaired hematopoietic long-term reconstitution. Here we report on studies that show that cytokine-treated cells maintain short-term reconstitution, but lose that potential with time posttransplantation. Hematopoietic progenitors assayed in vitro...

journal_title：International journal of hematology

authors： Peters SO,Habibian HK,Vergilis K,Quesenberry PJ

更新日期：1999-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce the differentiation of CD34(+) cells toward dendritic cells (DCs). We have previously shown that DCs are co-generated from human CD34(+) cells during erythroid or megakaryocytic differentiation in the presence of TNF-alpha, and those DCs are able to stim...

journal_title：International journal of hematology

authors： Saito Y,Guo YM,Hirokawa M,Saito K,Komatsuda A,Takahashi N,Fujishima M,Fujishima N,Yamashita J,Sawada K

更新日期：2008-07-01 00:00:00

abstract：:The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measur...

journal_title：International journal of hematology

authors： Ieko M,Yoshida M,Naito S,Nakabayashi T,Kanazawa K,Mizukami K,Mukai M,Atsumi T,Koike T

更新日期：2010-06-01 00:00:00

abstract：:We retrospectively reviewed clinical and hematologic features of nine patients with acquired idiopathic sideroblastic anemia (AISA). Seven of them had ringed sideroblasts (RS) more than 15% of marrow nucleated cells. RS persisted in the marrow even in the remaining two patients who had a relatively low marrow erythrob...

journal_title：International journal of hematology

authors： Yoshida Y,Oguma S,Tohyama K,Uchino H,Ito M,Takeda Y,Yoshinaga N,Tashima M,Sawada H,Okuma M

更新日期：1998-02-01 00:00:00

abstract：:Cold agglutinin disease (CAD) is a rare, complement-mediated autoimmune hemolytic anemia. Patients with CAD in the United States and Europe have an increased incidence of thromboembolism (TE), but comparable information for patients in other regions is lacking. Thus, we examined TE risk for patients with CAD in Japan....

journal_title：International journal of hematology

authors： Kamesaki T,Nishimura JI,Wada H,Yu E,Tsao E,Morales J,Kanakura Y

更新日期：2020-09-01 00:00:00

abstract：:Immunosuppression (IS) therapy with antilymphocyte globulin (ALG) is currently the treatment of choice for patients with aplastic anemia who do not have histocompatible sibling donors or who are not candidates for allogeneic bone marrow transplantation. Thirty-eight patients with aplastic anemia who received ALG-based...

journal_title：International journal of hematology

authors： Feng YH,Yen CJ,Huang WT,Su WC,Chen TY,Tsao CJ

更新日期：2004-02-01 00:00:00

abstract：:This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group). Apart from the classic risk factors, a number of hematological ...

journal_title：International journal of hematology

authors： Remacha AF,Souto JC,Piñana JL,Sardà MP,Queraltó JM,Martí-Fabregas J,García-Moll X,Férnandez C,Rodriguez A,Cuesta J

更新日期：2011-04-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report a patient with APL carrying a new complex variant translocation (5;17;15;20). Spectral karyotyping ana...

journal_title：International journal of hematology

authors： Yamanouchi J,Hato T,Niiya T,Miyoshi K,Azuma T,Sakai I,Yasukawa M

更新日期：2011-10-01 00:00:00

abstract：:Early thrombocytopenia is a common hematological abnormality in sick neonates. Here, we examined the relationship between early thrombocytopenia in neonates and parameters associated with thrombopoiesis to identify predictive factors at birth. Two hundred and forty-four neonates admitted to the neonatal intensive care...

journal_title：International journal of hematology

authors： Kihara H,Ohno N,Karakawa S,Mizoguchi Y,Fukuhara R,Hayashidani M,Nomura S,Nakamura K,Kobayashi M

更新日期：2010-03-01 00:00:00

abstract：:Hypocalcemic cardiomyopathy in primary or secondary hypoparathyroidism is usually refractory to conventional treatment of cardiac failure. We report the case of a thalassemic patient with severe cardiac failure that might have been attributed to several factors, such as hemosiderosis, hypomagnesemia, and hypocalcemia,...

journal_title：International journal of hematology

authors： Tsironi M,Korovesis K,Farmakis D,Deftereos S,Aessopos A

更新日期：2006-05-01 00:00:00

abstract：:Posttransplant lymphoproliferative disorder (PTLD) after allogeneic hematopoietic cell transplantation (HCT) is usually donor derived, associated with Epstein-Barr virus (EBV), and of B-cell origin. T-cell PTLD (T-PTLD) after allogeneic HCT is extremely rare. Four of 1015 (0.39%) allogeneic HCT patients were diagnosed...

journal_title：International journal of hematology

authors： Kuno M,Ito A,Maeshima AM,Taniguchi H,Tanaka T,Inamoto Y,Kurosawa S,Kim SW,Fukuda T

更新日期：2020-08-01 00:00:00

abstract：:The occurrence of chronic myeloid leukaemia (CML) in patients infected with the human immunodeficiency virus (HIV) has rarely been reported in the literature. In this report, we describe the experience of a single centre in the management of 10 such patients, including demographic information, disease characteristics ...

journal_title：International journal of hematology

authors： Webb MJ,Barrett CL,Pretorius C,van Jaarsveld MF,Louw VJ

更新日期：2012-05-01 00:00:00

abstract：:Some patients with hairy cell leukemia (HCL) manifest pancytopenia and bone marrow hypoplasia without an apparent increase in atypical cells, so their disease resembles severe aplastic anemia at onset. We treated 2 HCL patients, who were initially diagnosed with aplastic anemia, with antithymocyte globulin (ATG) in co...

journal_title：International journal of hematology

authors： Sugimori C,Kaito K,Nakao S

更新日期：2003-05-01 00:00:00

abstract：:The addition of rituximab to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) improved the outcome of patients with diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab (R-CHOP) is still not determined in primary mediastinal large B-cell lymphoma (PMBCL), a subtype of DLBCL, especial...

journal_title：International journal of hematology

authors： Ahn HK,Kim SJ,Yun J,Yi JH,Kim JH,Won YW,Kim K,Ko YH,Kim WS

更新日期：2010-04-01 00:00:00

abstract：:Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine t...

journal_title：International journal of hematology

authors： Kawada H,Ito T,Pharr PN,Spyropoulos DD,Watson DK,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：:Ferritin, composed of H-subunits and L-subunits, plays important roles in iron storage and in the control of intracellular iron distribution. Synthesis of both subunits is controlled by common cytoplasmic proteins, iron regulatory proteins (IRP-1 and IRP-2) that bind to the iron-responsive element (IRE) in the 5'-untr...

journal_title：International journal of hematology

authors： Kato J,Niitsu Y

更新日期：2002-10-01 00:00:00

abstract：:A.R.R.O.W. evaluated the superiority of once-weekly carfilzomib plus dexamethasone (Kd) 20/70 mg/m2 vs. twice-weekly Kd 20/27 mg/m2 based on progression-free survival (PFS) in relapsed and/or refractory multiple myeloma patients. Forty Japanese patients (once-weekly arm, n = 26; twice-weekly arm, n = 14) were randomiz...

journal_title：International journal of hematology

authors： Takezako N,Shibayama H,Handa H,Hagiwara S,Ozaki S,Suzuki K,Kosugi H,Ri M,Sugiura I,Choi I,Miyamoto T,Iida S

更新日期：2020-10-10 00:00:00

abstract：:We report an unusual dermatological reaction to bortezomib in a 61-year-old man with AL amyloidosis. Systemic AL amyloidosis is a rare complication of monoclonal gammopathy or myeloma in which abnormally unstable free light chains cause fibrillary deposits in organs leading to multisystem disease. The treatment of AL ...

journal_title：International journal of hematology

authors： Shah AD,Watts AJ,Mehta AB,Wechalekar AD

更新日期：2010-01-01 00:00:00

abstract：:We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

journal_title：International journal of hematology

authors： Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

更新日期：2015-12-01 00:00:00

abstract：:Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

journal_title：International journal of hematology

authors： Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

更新日期：2015-08-01 00:00:00

abstract：:The survival, proliferation, and differentiation of hematopoietic cells are regulated by cytokines. In the absence of cytokines, hematopoietic cells not only stop proliferation, but undergo apoptosis. This strict dependency of hematopoietic cells on cytokines is an important mechanism that maintains the homeostasis of...

journal_title：International journal of hematology

authors： Miyajima A,Ito Y,Kinoshita T

更新日期：1999-04-01 00:00:00

abstract：:IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 poly...

journal_title：International journal of hematology

authors： Bielska M,Borowiec M,Jesionek-Kupnicka D,Braun M,Bojo M,Pastorczak A,Kalinka-Warzocha E,Prochorec-Sobieszek M,Robak T,Warzocha K,Młynarski W,Lech-Marańda E

更新日期：2017-12-01 00:00:00

abstract：:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome b...

journal_title：International journal of hematology

authors： Hsiao HH,Hung YH,Hsiao HP,Tseng SB,Tsai HJ,Liu YC,Liu TC,Chao MC,Chang Y,Lin SF

更新日期：2004-11-01 00:00:00

abstract：:Mast cell sarcoma is a rare disease characterized by localized, but destructive and rapid, growth of the tumor, high risk of distant metastasis, possibility of a leukemic phase, and poor prognosis. We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdom...

journal_title：International journal of hematology

authors： Ma HB,Xu X,Liu WP,Chang H,Zeng F,Wang YC

更新日期：2011-11-01 00:00:00

abstract：:Persistent infection with human parvovirus B19 (B19) is primarily associated with chronic bone marrow failure in immunocompromised patients, but occasionally this organism may also affect immunocompetent hosts. B19 is also suggested as a causative agent of organ failure during bone marrow transplantation (BMT). We her...

journal_title：International journal of hematology

authors： Goto H,Ishida A,Fujii H,Kuroki F,Takahashi H,Ikuta K,Kai S,Yokota S

更新日期：2004-05-01 00:00:00

abstract：:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

journal_title：International journal of hematology

authors： Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

更新日期：2014-06-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNA-21 (miR-21), as an oncogene, is involved in the occurrence of many types of tumor and the sensitivity of tumor cells to chemotherapeutic drugs. In the present study, we investigated whether miR-21 is involved in regulating the sensitivity of the diffuse large B-cell lym...

journal_title：International journal of hematology

authors： Bai H,Wei J,Deng C,Yang X,Wang C,Xu R

更新日期：2013-02-01 00:00:00

abstract：:We report successful treatment with 25 microg/kg of recombinant methionyl human stem cell factor (SCF) combined with 400 microg/m2 of recombinant human granulocyte colony-stimulating factor (G-CSF) in 2 patients with aplastic anemia refractory to immunosuppressive therapy. In one patient, hemoglobin levels increased f...

journal_title：International journal of hematology

authors： Usuki K,Iki S,Arai S,Iijima K,Takaku F,Urabe A

更新日期：2006-06-01 00:00:00