Safety of ASP0113, a cytomegalovirus DNA vaccine, in recipients undergoing allogeneic hematopoietic cell transplantation: an open-label phase 2 trial.

abstract：:Recent studies have indicated that Fas and perforin-based mechanisms seem to induce apoptosis in histiocytic necrotizing lymphadenitis (HNL). In this study, we evaluated the serum levels of soluble Fas ligand (sFasL) in 30 HNL patients using paired sera. Elevations in sFasL levels were detected in 9 patients in the ac...

journal_title：International journal of hematology

authors： Kato K,Ohshima K,Anzai K,Suzumiya J,Kikuchi M

更新日期：2001-01-01 00:00:00

abstract：:Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

journal_title：International journal of hematology

authors： Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

更新日期：2014-01-01 00:00:00

abstract：:A 2-year-old Japanese boy who presented with multiple cervical, axillary, and inguinal lymphadenopathy was diagnosed by immunocytochemical analysis as having myeloid/natural killer (NK) cell precursor acute leukemia. Leukemic blasts in the bone marrow were positive for CD56 (NK marker), CD7 (T-cell marker), CD33 (myel...

journal_title：International journal of hematology

authors： Tezuka K,Nakayama H,Honda K,Suzumiya J,Oshima K,Kitoh T,Ishii E

更新日期：2002-02-01 00:00:00

abstract：:We evaluated endogenous serum erythropoietin (Epo) levels in 14 normal subjects (eight males and six females) after a single 400-ml phlebotomy. The subjects were followed up for 56 days. The hemoglobin (Hb) values of both males and females decreased to a nadir on days 3 to 7 post-phlebotomy. Hb values gradually increa...

journal_title：International journal of hematology

authors： Maeda H,Hitomi Y,Hirata R,Tohyama H,Suwata J,Kamata S,Fujino Y,Murata N

更新日期：1992-04-01 00:00:00

abstract：:Human granulocyte colony-stimulating factor (G-CSF) receptor cDNA was introduced into the erythroleukemic cell line K562, which normally does not express the receptor, using lipofection transfection of a G-CSF receptor expression plasmid vector. Transfected cells expressed the receptor with a dissociation constant of ...

journal_title：International journal of hematology

authors： el-Sonbaty SS,Watanabe M,Hochito K,Yamaguchi K,Matsuda I,Tsuchiya H

更新日期：1995-02-01 00:00:00

abstract：:Acquired aplastic anemia (AA) is considered an immune-mediated disease because approximately 70% of AA patients improve with immunosuppressive therapy. However, little is known about the inciting antigens or the mechanisms responsible for the destruction of hematopoietic stem cells by immune system attack. Recent adva...

journal_title：International journal of hematology

authors： Nakao S,Feng X,Sugimori C

更新日期：2005-10-01 00:00:00

abstract：:Embryonic stem (ES) cells are derived from blastocysts and are pluripotent. This pluripotency has attracted the interest of numerous researchers, both to expand our fundamental understanding of developmental biology and also because of potential applications in regenerative medicine. Systems biological studies have de...

journal_title：International journal of hematology

authors： Masui S

更新日期：2010-04-01 00:00:00

abstract：:Chronic atrial fibrillation (AF) has often been associated with systemic embolization, and patients with mitral stenosis (MS) have the highest thromboembolic risk. Increased risk of thromboembolism could be in part due to impaired fibrinolytic function. Global fibrinolytic capacity (GFC) is an innovative technique for...

journal_title：International journal of hematology

authors： Atalar E,Ozmen F,Haznedaroğlu I,Ozer N,Aksöyek S,Ovünç K,Nazli N,Kirazli S,Kes S

更新日期：2002-08-01 00:00:00

abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is now undergoing clinical trials. We investigated the effects of rhG-CSF on the function of neutrophils in vivo in healthy volunteers. rhG-CSF (0.5 micrograms/kg) was injected subcutaneously for 6 consecutive days. The number of neutrophils in peripher...

journal_title：International journal of hematology

authors： Itoh Y,Kuratsuji T,Tsunawaki S,Aizawa S,Toyama K

更新日期：1991-12-01 00:00:00

abstract：:We describe an interesting case of a patient with chronic myelogenous leukemia (CML) who developed sustained severe bone marrow aplasia after 2 years and 11 months of interferon-alpha (IFN-alpha) therapy but demonstrated recovery of normal hematopoiesis when treated with immunosuppressive therapy with granulocyte-colo...

journal_title：International journal of hematology

authors： Hishida A,Yamamoto K,Kato C,Yokozawa T,Emi N,Tanimoto M,Saito H

更新日期：2003-01-01 00:00:00

abstract：:This observational study aimed to assess real-world treatment patterns and clinical outcomes for patients with chronic immune thrombocytopenia (ITP) currently being treated with eltrombopag or romiplostim after switching from corticosteroids, rituximab, or the alternate thrombopoietin receptor agonist (TPO-RA). The st...

journal_title：International journal of hematology

authors： Kuter DJ,Macahilig C,Grotzinger KM,Poston SA,Wang PF,Dawson KL,Ward M

更新日期：2015-03-01 00:00:00

abstract：:The antitumor effect of high-dose chemotherapy (HDC) followed by autologous peripheral blood stem cell transplantation (auto-PBSCT) is considered superior to that of conventional chemotherapy. However, the long-term benefits of this strategy in Japan remain unclear. Therefore, in this study, 109 cancer patients enroll...

journal_title：International journal of hematology

authors： Kohda K,Sakamaki S,Matsunaga T,Kuga T,Fujimi A,Konuma Y,Kusakabe T,Kogawa K,Akiyama T,Koike K,Hirayama Y,Sasagawa Y,Nojiri S,Hirata Y,Nishisato T,Niitsu GY,Hokkaido Society of Peripheral Blood Stem Cell Transplantation.

更新日期：2001-02-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:The de-novo synthesis and secretion of beta-thromboglobulin (BTG) by a human megakaryoblastic cell line (MEG-01) were studied by measuring and immunoblotting of BTG in culture supernatant and immunoprecipitation of radiolabeled BTG synthesized after incubation with [35S]methionine. It was demonstrated that BTG synthes...

journal_title：International journal of hematology

authors： Tanabe N,Ogura M,Hotta T,Takamatsu J,Tanaka M,Saito H

更新日期：1991-04-01 00:00:00

abstract：:We identified two afibrinogenemic girls in two Japanese families and performed molecular analysis to clarify the mechanisms of fibrinogen defects. Genetic analyses were performed by PCR amplification of the fibrinogen gene and DNA sequence analysis. To analyze the mechanisms of mature fibrinogen defects in plasma, we ...

journal_title：International journal of hematology

authors： Takezawa Y,Terasawa F,Matsuda K,Sugano M,Tanaka A,Fujiwara M,Kainuma K,Okumura N

更新日期：2012-07-01 00:00:00

abstract：:Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). It commonly presents with a variety of symptoms due to occlusion of small vessels by tumor cells in different organ systems. Clinically patients may present with generalized symptoms such as fever and malaise. In w...

journal_title：International journal of hematology

authors： Yin W,Li M,Gao Z,Huang F,Da J,Liu C

更新日期：2009-04-01 00:00:00

abstract：:Osteonecrosis (ON) is a potentially disabling complication encountered in children who receive chemotherapy for acute lymphoblastic leukemia (ALL). Considering the possible effect of ethnic difference on the clinical features of symptomatic ON in pediatric ALL, we retrospectively evaluated 245 children with ALL who we...

journal_title：International journal of hematology

authors： Chen SH,Chang TY,Jaing TH,Lee MS,Wang CJ,Hung IJ,Yang CP

更新日期：2015-07-01 00:00:00

abstract：:We statistically analyzed the hematologic findings of patients with refractory anemia (RA) to identify parameters associated with a poor prognosis. We first separated the RA patients into two groups: one group with disease progression and one without. The patients with disease progression were predominantly male and h...

journal_title：International journal of hematology

authors： Iwabuchi A,Ohyashiki K,Ohyashiki JH,Kimura Y,Lin KY,Aizawa S,Nehashi Y,Miyazawa K,Yaguchi M,Toyama K

更新日期：1994-10-01 00:00:00

abstract：:We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

journal_title：International journal of hematology

authors： Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

更新日期：2015-05-01 00:00:00

abstract：:A multiple myeloma (MM) cell line, MSG1, which depends on HS23 stromal cells for its survival, was established from the pleural effusion of a patient with MM who expressed the M-protein of IgA-λ in his serum. During the first 2 months of culture, the myeloma cells survived on adhesive cells from the pleural effusion a...

journal_title：International journal of hematology

authors： Sakai A,Oda M,Itagaki M,Yoshida N,Arihiro K,Kimura A

更新日期：2010-11-01 00:00:00

abstract：:A 29-year-old woman presented to the emergency department with exhaustion, fatigue, and abdominal pain. She reported having received a diagnosis of bulimia nervosa 10 years before. On examination, she had a marked pallor and was severely malnourished. Laboratory analysis revealed a dramatically low hemoglobin level of...

journal_title：International journal of hematology

authors： Jost PJ,Stengel SM,Huber W,Sarbia M,Peschel C,Duyster J

更新日期：2005-11-01 00:00:00

abstract：:Diffuse follicular lymphoma (FL) variant is a rare condition that shows distinctive clinical, morphological, immunophenotypic, and molecular features that distinguish it from classical FL. Diffuse FL variant is characterized by a predominantly diffuse growth pattern, absence of the t (14;18) IGH/BCL2 translocation, CD...

journal_title：International journal of hematology

authors： Martín-Moro F,Marquet-Palomanes J,Piris-Villaespesa M,Lopez-Jiménez J,García-Cosío M

更新日期：2020-08-01 00:00:00

abstract：:Myeloid/NK cell precursor lymphoma/leukemia has been suggested to be of precursor NK origin. We report a 1-year-old boy with myeloid/NK cell precursor lymphoma/leukemia who presented with a skin nodule. Biopsy of the skin nodule specimen revealed CD45(+), CD56(+), myeloid antigen(+), CD7(-), CD3(-), CD19(-), CD34(-), ...

journal_title：International journal of hematology

authors： Hashii Y,Okuda T,Ohta H,Ozono K,Hara J

更新日期：2010-04-01 00:00:00

abstract：:CCR4 is expressed on tumor cells of most patients with adult T-cell leukemia/lymphoma (ATL). Gain-of-function mutations of the CCR4 gene in ATL patients may be associated with alterations at the carboxyl terminus, a finding which led to a high efficacy anti-CCR4 antibody, mogamulizumab. Only a few studies have reporte...

journal_title：International journal of hematology

authors： Sakamoto Y,Fujii K,Murase S,Nakano S,Masaki A,Murase T,Kusumoto S,Iida S,Utsunomiya A,Ueda R,Ishida T,Inagaki H

更新日期：2019-10-01 00:00:00

abstract：:We describe the case of a 62-year-old man with biopsy-proven cardiac involvement of multiple myeloma-associated immunoglobulin light-chain amyloidosis, whose cardiac function improved after bortezomib therapy. Angiotensin-converting enzyme inhibitors and diuretics were initially administered, resulting in improvement ...

journal_title：International journal of hematology

authors： Tamaki H,Naito Y,Lee-Kawabata M,Taniguchi Y,Hao H,Hirota S,Hasegawa S,Masuyama T,Ogawa H

更新日期：2010-11-01 00:00:00

abstract：:The role of reactive oxygen species (ROS) in the cytotoxicity of N-(4-hydroxyphenyl)retinamide (4-HPR) was studied with use of the B-precursor lymphoblastic leukemia cell line YCUB-2. The increase in intracellular ROS measured with 2'-7'-dichlorodihydrofluorescein diacetate after 3 hours' incubation was 3.7-fold with ...

journal_title：International journal of hematology

authors： Goto H,Takahashi H,Fujii H,Ikuta K,Yokota S

更新日期：2003-10-01 00:00:00

abstract：:Dyskeratosis congenita (DC) is an inherited disease associated with nail dystrophy, abnormal skin pigmentation, oral leukoplakia, bone marrow failure and a predisposition to cancer. DC is a disease of defective telomere maintenance and patients with DC have very short telomeres. To date, mutations in six genes of telo...

journal_title：International journal of hematology

authors： Nishio N,Kojima S

更新日期：2010-10-01 00:00:00

abstract：:Spontaneous improvement (SI) occurs more frequently in children with chronic immune thrombocytopenia (cITP) than in adults. It is generally accepted that, with the exception of splenectomy, conventional medical approaches for cITP do not change the natural course of the disease. Previous studies on pediatric cITP have...

journal_title：International journal of hematology

authors： Kato M,Koh K,Kikuchi A,Hanada R

更新日期：2012-12-01 00:00:00

abstract：:Novel approaches to the treatment of haemophilia are needed due to the limitations of the current standard of care, factor replacement therapy. Aspirations include lessening the treatment burden and effectively preventing joint damage. Treating haemophilia by restoring thrombin generation may be an effective approach....

journal_title：International journal of hematology

authors： Chowdary P

更新日期：2020-01-01 00:00:00

abstract：:Both stem cells and progenitor cells are present in umbilical cord blood (UCB) at a high frequency, making these cells a major target population for experimental and clinical studies. As the use of autologous or allogeneic hematopoietic stem cell transplantation in the treatment of various diseases has grown rapidly i...

journal_title：International journal of hematology

authors： Lee MW,Jang IK,Yoo KH,Sung KW,Koo HH

更新日期：2010-07-01 00:00:00